RECQL5, RecQ like helicase 5, 9400

N. diseases: 28; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 Biomarker group BEFREE Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5. 27764811 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 Biomarker group BEFREE Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5. 27764811 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 Biomarker group BEFREE The RecQL5 helicase is essential for maintaining genome stability and reducing cancer risk. 20231364 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 Biomarker group BEFREE The RecQL5 helicase is essential for maintaining genome stability and reducing cancer risk. 20231364 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 GeneticVariation group BEFREE Although the two remaining helicases, RECQL1 and RECQL5, have not yet been associated with heritable human diseases, a single nucleotide polymorphism of RECQL1 is associated with reduced survival of pancreatic cancer, and RecQl5 knockout mice show a predisposition to cancer. 18719387 2008
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 GeneticVariation group BEFREE Although the two remaining helicases, RECQL1 and RECQL5, have not yet been associated with heritable human diseases, a single nucleotide polymorphism of RECQL1 is associated with reduced survival of pancreatic cancer, and RecQl5 knockout mice show a predisposition to cancer. 18719387 2008
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.040 GeneticVariation group BEFREE Here we show that deletion of Recql5 in mice results in cancer susceptibility. 18003859 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 GeneticVariation group BEFREE Here we show that deletion of Recql5 in mice results in cancer susceptibility. 18003859 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 Biomarker group BEFREE Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment. 26499077 2015
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.030 Biomarker disease BEFREE Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment. 26499077 2015
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.030 GeneticVariation disease BEFREE Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population. 25867335 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.030 Biomarker disease BEFREE Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment. 26499077 2015
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.030 GeneticVariation disease BEFREE Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population. 25867335 2015
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.030 GeneticVariation disease BEFREE Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population. 25867335 2015
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.030 Biomarker disease BEFREE Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment. 26499077 2015
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.030 GeneticVariation disease BEFREE Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population. 24287950 2014
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.030 GeneticVariation disease BEFREE Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population. 24287950 2014
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.030 GeneticVariation disease BEFREE Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population. 24287950 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 Biomarker group BEFREE The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells. 21402780 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 Biomarker group BEFREE Together, our results identify RECQL5 as an important tumor suppressor that may act by preventing inappropriate HR events via Rad51 presynaptic filament disruption. 18003859 2007
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
0.020 Biomarker disease BEFREE Collectively, our results indicate that RECQL5 plays both co-operative and complementary roles with WRN. 28180303 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.020 AlteredExpression disease BEFREE In this study, we have evaluated RECQL5 mRNA expression in 1977 breast cancers, and RECQL5 protein level in 1902 breast cancers [Nottingham Tenovus series (n = 1650) and ER- cohort (n = 252)]. 26586793 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.020 AlteredExpression disease BEFREE The clinicopathological significance of RECQL5 expression in breast cancer is unknown. 26586793 2016
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.020 GeneticVariation disease BEFREE We found that rs820196 and rs828200 polymorphisms of RECQL5 were associated with breast cancer. 25394896 2014
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome
0.020 Biomarker disease BEFREE In the acquired forms, genes such as LMNA, PPARG, CIDEC (cell-death-inducing DNA fragmentation factor a-like effector c) and PLIN1 are heavily involved in familial partial lipodystrophy (FPLD) type 2 (also known as the Dunnigan-Variety) and WRN along with RECQL5 in Werner Syndrome (WS). 24152769 2014