Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5.
|
27764811 |
2016 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5.
|
27764811 |
2016 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The RecQL5 helicase is essential for maintaining genome stability and reducing cancer risk.
|
20231364 |
2010 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
The RecQL5 helicase is essential for maintaining genome stability and reducing cancer risk.
|
20231364 |
2010 |
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Although the two remaining helicases, RECQL1 and RECQL5, have not yet been associated with heritable human diseases, a single nucleotide polymorphism of RECQL1 is associated with reduced survival of pancreatic cancer, and RecQl5 knockout mice show a predisposition to cancer.
|
18719387 |
2008 |
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Although the two remaining helicases, RECQL1 and RECQL5, have not yet been associated with heritable human diseases, a single nucleotide polymorphism of RECQL1 is associated with reduced survival of pancreatic cancer, and RecQl5 knockout mice show a predisposition to cancer.
|
18719387 |
2008 |
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Here we show that deletion of Recql5 in mice results in cancer susceptibility.
|
18003859 |
2007 |
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Here we show that deletion of Recql5 in mice results in cancer susceptibility.
|
18003859 |
2007 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment.
|
26499077 |
2015 |
Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment.
|
26499077 |
2015 |
Osteosarcoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.
|
25867335 |
2015 |
Osteosarcoma of bone
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment.
|
26499077 |
2015 |
Osteosarcoma of bone
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.
|
25867335 |
2015 |
Childhood Osteosarcoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.
|
25867335 |
2015 |
Childhood Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, our results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment.
|
26499077 |
2015 |
Osteosarcoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population.
|
24287950 |
2014 |
Osteosarcoma of bone
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population.
|
24287950 |
2014 |
Childhood Osteosarcoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population.
|
24287950 |
2014 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells.
|
21402780 |
2011 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Together, our results identify RECQL5 as an important tumor suppressor that may act by preventing inappropriate HR events via Rad51 presynaptic filament disruption.
|
18003859 |
2007 |
Werner Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Collectively, our results indicate that RECQL5 plays both co-operative and complementary roles with WRN.
|
28180303 |
2017 |
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we have evaluated RECQL5 mRNA expression in 1977 breast cancers, and RECQL5 protein level in 1902 breast cancers [Nottingham Tenovus series (n = 1650) and ER- cohort (n = 252)].
|
26586793 |
2016 |
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The clinicopathological significance of RECQL5 expression in breast cancer is unknown.
|
26586793 |
2016 |
Malignant neoplasm of breast
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We found that rs820196 and rs828200 polymorphisms of RECQL5 were associated with breast cancer.
|
25394896 |
2014 |
Werner Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
In the acquired forms, genes such as LMNA, PPARG, CIDEC (cell-death-inducing DNA fragmentation factor a-like effector c) and PLIN1 are heavily involved in familial partial lipodystrophy (FPLD) type 2 (also known as the Dunnigan-Variety) and WRN along with RECQL5 in Werner Syndrome (WS).
|
24152769 |
2014 |