|
Colorectal Carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
This present study verified fibulin 2 (FBLN2) and protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A) to be downregulated in the CRC tissue sample but upregulated in CRC cell lines following 5-aza-dC treatment.
|
28928808 |
2017 |
|
Colorectal Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.
|
17892325 |
2007 |
|
Mesothelioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Our hypothesis was that in human mesothelioma without detectable NF2 mutations, regulators of NF2/merlin activity such as CPI-17 would be altered.
|
18835652 |
2009 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.
|
17892325 |
2007 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
CPI-17 can drive Ras activity and promote tumorigenic transformation by inhibiting the tumor suppressor merlin.
|
31789805 |
2020 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
NF2 mutations and CPI-17 expression together induce merlin phosphorylation, which is correlated with the tumorigenesis of sporadic VSs.
|
31789805 |
2020 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Thus, CPI-17 drives Ras activity and tumorigenesis in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family.
|
27793041 |
2016 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, CPI-17 drives Ras activity and tumorigenesis in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family.
|
27793041 |
2016 |
|
Benign Prostatic Hyperplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our data provide insight into how GATA-6 and NF-κB mediate CPI-17 transcription, PKC-mediated signaling, and BSM remodeling associated with lower urinary tract symptoms in patients with BPH.
|
23275439 |
2013 |
|
Benign Prostatic Hyperplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
A Western blot analysis revealed the expression of PKC-potentiated protein phosphatase-1 inhibitory protein (CPI-17) in both CHPSCs and fresh human BPH tissue to be much lower than that in the rabbit aorta.
|
16052505 |
2005 |
|
Acoustic Neuroma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blotting was used to determine the level of merlin phosphorylation, and immunohistochemistry and Western blotting were used to measure CPI-17 expression in the sporadic VS samples.
|
31789805 |
2020 |
|
Hypertensive disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We therefore propose that the upregulation of CPI-17-mediated calcium-sensitized vasocontraction by obesity contributes to the development of obesity-related hypertension.
|
30948334 |
2019 |
|
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We therefore propose that the upregulation of CPI-17-mediated calcium-sensitized vasocontraction by obesity contributes to the development of obesity-related hypertension.
|
30948334 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, these data provide a novel mechanism of the transcriptional control of CPI-17 in vascular smooth muscle cells under inflammatory conditions and suggest a new potential therapeutic strategy for the treatment of vasodilatory shock in sepsis.
|
30936247 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, these data provide a novel mechanism of the transcriptional control of CPI-17 in vascular smooth muscle cells under inflammatory conditions and suggest a new potential therapeutic strategy for the treatment of vasodilatory shock in sepsis.
|
30936247 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, 4 genes, MSMB, NCOA4, PCAT1, and PPP1R14A, are associated with PrCa in a trans-ethnic meta-analysis (N = 9117).
|
31308362 |
2019 |
|
Prostate carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, 4 genes, MSMB, NCOA4, PCAT1, and PPP1R14A, are associated with PrCa in a trans-ethnic meta-analysis (N = 9117).
|
31308362 |
2019 |
|
Hypotension, Orthostatic
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Prolonged bed rest impairs rapid CPI-17 phosphorylation and contraction in rat mesenteric resistance arteries to cause orthostatic hypotension.
|
28717991 |
2017 |
|
Necrotizing enterocolitis in fetus OR newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of immunohistochemistry showed that the staining intensities of MYPT1, CPI-17 and MLC20 in the NEC group were lighter than those in the control group, and the proportion of positive cells was also lower in the NEC group (P<0.01).
|
28962146 |
2017 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The in vivo significance of this oncogenic switch is highlighted by demonstrating CPI-17's involvement in human melanoma pathogenesis.
|
27793041 |
2016 |
|
Bladder neck obstruction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GATA-6 and NF-κB overexpression was associated with CPI-17 overexpression in BSM from men with benign prostatic hyperplasia (BPH)-induced bladder hypertrophy and in a mouse model of bladder outlet obstruction.
|
23275439 |
2013 |
|
Malignant Neoplasms
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Nuclear localization of CPI-17, a protein phosphatase-1 inhibitor protein, affects histone H3 phosphorylation and corresponds to proliferation of cancer and smooth muscle cells.
|
23541585 |
2013 |
|
Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
The DNA methylation biomarker panel consisting of DSP, FZD8, KCNH2, and PPP1R14A was positive in 89% (54/61) of all lymphomas.
|
24260260 |
2013 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CPI-17 knockdown in Panc1 resulted in dephosphorylation of histone H3 at Thr3, Ser10 and Thr11, whereas it had no effects on the phosphorylation of myosin light chain and merlin, the known targets of MLCP.
|
23541585 |
2013 |
|
Hypertrophy of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GATA-6 and NF-κB overexpression was associated with CPI-17 overexpression in BSM from men with benign prostatic hyperplasia (BPH)-induced bladder hypertrophy and in a mouse model of bladder outlet obstruction.
|
23275439 |
2013 |