Diabetes Mellitus, Non-Insulin-Dependent
|
0.620 |
PosttranslationalModification
|
disease |
BEFREE |
The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes.
|
29129046 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.620 |
GeneticVariation
|
disease |
BEFREE |
Sibpair analyses performed on i49 multiplex French families with type 2 diabetes excluded MAPK8IP1 as a major diabetogenic locus.
|
10700186 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.620 |
GeneticVariation
|
disease |
UNIPROT |
Sibpair analyses performed on i49 multiplex French families with type 2 diabetes excluded MAPK8IP1 as a major diabetogenic locus.
|
10700186 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.620 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.620 |
Biomarker
|
disease |
HPO |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.620 |
Biomarker
|
disease |
CTD_human |
|
|
|
Depressed bipolar I disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies 30 loci associated with bipolar disorder.
|
31043756 |
2019 |
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
Insulin Resistance
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Decreased waist to hip ratio
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
JIP1 plays significant and broad roles in neurons, mainly as a regulator of kinesin1-dependent transport, and is associated with human pathologies such as cancer and Alzheimer disease.
|
30026235 |
2018 |
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
However, this polymorphism increased the risk of AD conferred by the MAPK8IP1 G allele.
|
17614163 |
2009 |
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
In two separate French populations the -499A>G polymorphism of MAPK8IP1 was not associated with an increased risk to AD.
|
12740599 |
2003 |
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In two separate French populations the -499A>G polymorphism of MAPK8IP1 was not associated with an increased risk to AD.
|
12740599 |
2003 |
Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease.
|
30013340 |
2018 |
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease.
|
30013340 |
2018 |
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease.
|
30013340 |
2018 |
Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3.
|
23045411 |
2012 |
Osteosarcoma of bone
|
0.020 |
Biomarker
|
disease |
BEFREE |
A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3.
|
23045411 |
2012 |
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3.
|
23045411 |
2012 |
Nephroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
When six primary Wilms tumours (nephroblastomas) from pig were examined, the two genes showed a high degree of co-variation in the sense that high or low expression of IGF-II and high or low expression of JIP-1 ocurred together.
|
20044608 |
2009 |
Nephroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of JNK-interacting protein JIP-1 and insulin-like growth factor II in Wilms tumour cell lines and primary Wilms tumours.
|
19596915 |
2009 |
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggested that HO-1 could ameliorate brain injury by regulating the MLK3-MKK7-JNK3 signaling module, which was scaffolded by JIP1 and JNK signaling during cerebral ischemia/reperfusion.
|
30412737 |
2019 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
JIP1 plays significant and broad roles in neurons, mainly as a regulator of kinesin1-dependent transport, and is associated with human pathologies such as cancer and Alzheimer disease.
|
30026235 |
2018 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease.
|
30013340 |
2018 |