Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.620 PosttranslationalModification disease BEFREE The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. 29129046 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.620 GeneticVariation disease BEFREE Sibpair analyses performed on i49 multiplex French families with type 2 diabetes excluded MAPK8IP1 as a major diabetogenic locus. 10700186 2000
Diabetes Mellitus, Non-Insulin-Dependent
0.620 GeneticVariation disease UNIPROT Sibpair analyses performed on i49 multiplex French families with type 2 diabetes excluded MAPK8IP1 as a major diabetogenic locus. 10700186 2000
Diabetes Mellitus, Non-Insulin-Dependent
0.620 CausalMutation disease CLINVAR
Diabetes Mellitus, Non-Insulin-Dependent
0.620 Biomarker disease HPO
Diabetes Mellitus, Non-Insulin-Dependent
0.620 Biomarker disease CTD_human
CUI: C0236773
Disease: Depressed bipolar I disorder
Depressed bipolar I disorder
0.100 GeneticVariation disease GWASCAT Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
High density lipoprotein measurement
0.100 GeneticVariation phenotype GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance
0.100 Biomarker phenotype HPO
CUI: C4703555
Disease: Decreased waist to hip ratio
Decreased waist to hip ratio
0.100 Biomarker phenotype HPO
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.030 Biomarker disease BEFREE JIP1 plays significant and broad roles in neurons, mainly as a regulator of kinesin1-dependent transport, and is associated with human pathologies such as cancer and Alzheimer disease. 30026235 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.030 GeneticVariation disease BEFREE However, this polymorphism increased the risk of AD conferred by the MAPK8IP1 G allele. 17614163 2009
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.030 GeneticVariation disease LHGDN In two separate French populations the -499A>G polymorphism of MAPK8IP1 was not associated with an increased risk to AD. 12740599 2003
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.030 GeneticVariation disease BEFREE In two separate French populations the -499A>G polymorphism of MAPK8IP1 was not associated with an increased risk to AD. 12740599 2003
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.020 Biomarker disease BEFREE We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease. 30013340 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.020 Biomarker disease BEFREE We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease. 30013340 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.020 Biomarker disease BEFREE We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease. 30013340 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.020 Biomarker disease BEFREE A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3. 23045411 2012
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.020 Biomarker disease BEFREE A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3. 23045411 2012
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.020 Biomarker disease BEFREE A panel of OS cell lines and human primary osteoblasts was examined for sensitisation to doxorubicin using small molecule JIP1-inhibitor BI-78D3. 23045411 2012
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.020 AlteredExpression disease BEFREE When six primary Wilms tumours (nephroblastomas) from pig were examined, the two genes showed a high degree of co-variation in the sense that high or low expression of IGF-II and high or low expression of JIP-1 ocurred together. 20044608 2009
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.020 AlteredExpression disease BEFREE Expression of JNK-interacting protein JIP-1 and insulin-like growth factor II in Wilms tumour cell lines and primary Wilms tumours. 19596915 2009
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction
0.010 Biomarker disease BEFREE Taken together, these findings suggested that HO-1 could ameliorate brain injury by regulating the MLK3-MKK7-JNK3 signaling module, which was scaffolded by JIP1 and JNK signaling during cerebral ischemia/reperfusion. 30412737 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE JIP1 plays significant and broad roles in neurons, mainly as a regulator of kinesin1-dependent transport, and is associated with human pathologies such as cancer and Alzheimer disease. 30026235 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker phenotype BEFREE We aimed to create dual-targeted (extracellular against EphA2 and intracellular against JNK-interacting protein 1 [JIP1]), doxorubicin (DOX)-loaded liposomes to treat OS metastatic disease. 30013340 2018