GDF15, growth differentiation factor 15, 9518

N. diseases: 389; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE GDF-15 is induced in hypertrophic and dilated cardiomyopathy after volume overload, ischemia, and heart failure. 31663791 2020
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression disease BEFREE In this study we compared the plasma levels of NT-proBNP versus GDF-15 in patients with HF in AF versus sinus rhythm (SR). 31263996 2020
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Although, in general, effects of NRG-1 in heart failure are compensatory and beneficial, translation into therapies remains unaccomplished both because of the complexity of the underlying pathways and because of the challenges in the development of therapeutics (proteins, peptides, small molecules, and RNA-based therapies) for tyrosine kinase receptors. 31607147 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE In the setting of ACS, GDF-15 is associated with long-term all-cause death, MACE and heart failure and provides incremental prognostic value beyond traditional risks factor. 31369736 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Safety, Tolerability and efficacy of Rapid Optimization, helped by NT-proBNP and GDF-15, of Heart Failure therapies (STRONG-HF): rationale and design for a multicentre, randomized, parallel-group study. 31423712 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Furthermore, we evaluated whether GDF-15 was associated with CV death or heart failure (HF) across the spectrum of risk in non-ST-segment elevation (NSTE)-ACS. 30710475 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE The Role of GDF-15 in Heart Failure Patients With Chronic Kidney Disease. 30935637 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression disease BEFREE We aimed to analyse the association between high-level growth-differentiation factor-15 (GDF-15) and mortality, recurrent MI and heart failure compared to low-level GDF-15 in patients with acute coronary syndrome (ACS). 31029521 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Higher NT-proBNP, hsTnT, and GDF-15 were also associated with a greater risk of HF with reduced EF; while higher NT-proBNP GDF-15 and sST2 were associated with HF with preserved EF. 31645163 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE GDF-15, a member of the transforming growth factor beta superfamily, regulates inflammatory and apoptotic pathways in various diseases, such as heart failure, kidney dysfunction, and cancer. 31476622 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Plasma GDF-15 is an independent predictor of all-cause mortality in Chinese patients with HF. 28612904 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE In pooled analysis of both cohorts, higher levels of nine proteins were associated with incident heart failure after adjustment for established risk factors: growth differentiation factor 15 (GDF-15), T-cell immunoglobulin and mucin domain 1 (TIM-1), tumour necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2), spondin-1 (SPON1), matrix metalloproteinase-12 (MMP-12), follistatin (FS), urokinase-type plasminogen activator surface receptor (U-PAR), osteoprotegerin (OPG), and suppression of tumorigenicity 2 (ST2). 28967680 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Biomarkers were the strongest predictors of cause-specific death: a doubling of troponin T was most strongly associated with sudden death (hazard ratio [HR], 1.48; P<0.001), NT-proBNP with heart failure death (HR, 1.62; P<0.001), and growth differentiation factor-15 with bleeding death (HR, 1.72; P=0.028). 29871978 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE GDF-15 is a promising biomarker for prediction of HF and death due to CHD in the general population, which may provide prognostic information to already established clinical biomarkers. 29771963 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 GeneticVariation disease BEFREE Each 20% increment in baseline GDF-15 value was associated with a higher risk of mortality [adjusted hazard ratio (HR) 1.13, 95% confidence interval (CI) 1.08-1.18, P < 0.001], the combined endpoint of CV death or hospitalization for heart failure (adjusted HR 1.09, 95% CI 1.05-1.14, P < 0.001) and heart failure death (adjusted HR 1.16, 95% CI 1.05-1.28, P < 0.001). 30204280 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE The objective of this study was to evaluate the prognostic impact of plasma GDF-15 and BNP in acute HF. 30144302 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE GDF-15 and left ventricular mass index (LVMI) were significantly increased as early as the pre-clinical HF stage. 30019695 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Next-generation biomarkers including soluble source of tumorigenicity 2 (sST2), growth differentiation factor-15 (GDF-15), galectin-3 (Gal-3) and diverse microribonucleic acids (miRNAs) may have additional benefit in assessment of cardiac remodeling or differentiation of HF subtypes. 29682806 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE In addition, clinical studies indicate that circulating, mature GDF15 is an independent biomarker for heart failure. 30104250 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression disease BEFREE In patients with acute coronary syndrome, baseline levels of NT-proBNP and GDF-15 were strong markers associated with all-cause death based on their associations with death due to heart failure as well as due to arrhythmia and sudden cardiac death. 30427997 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Elevated GDF-15 concentration was also associated with an increased rate of heart failure. 29866459 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Because myocardial NRG-1/ErbB signaling has been documented to be impaired during HF associated with type 1 DM, we examined whether enhancement of NRG-1β signaling via exogenous administration of recombinant NRG-1β could exert beneficial effects against post-MI HF in the type 1 diabetic heart. 28870731 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE The hazard ratio for the composite end point for the highest compared to the lowest quartile of GDF-15 was 1.8 (95% CI, 1.5-2.2); for CV death, 2.63 (1.9-3.6); for sudden death, 3.06 (1.9-4.8); for heart failure (HF) death, 4.3 (1.3-14); for cancer death, 2.5 (1.3-4.7); for hospitalization for HF, 5.8 (3.2-10); for MI 1.4 (95% CI, 1.1-1.9); and for stroke, 1.8 (95% CI, 1.1-2.8). 27811204 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Discrimination of subjects with and without HF was slightly higher for GDF-15 (area under the ROC curve [AUC]:0.79 [95%CI:0.75-0.83]) compared to NT-proBNP (AUC:0.77 [95% CI:0.72-0.82]). 27838133 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 Biomarker disease BEFREE Growth/differentiation factor 15 (GDF15), also known as MIC-1, is a distant member of the transforming growth factor-β (TGF-β) superfamily and has been implicated in various biological functions, including cancer cachexia, renal and heart failure, atherosclerosis and metabolism. 28846098 2017