GDF15, growth differentiation factor 15, 9518

N. diseases: 389; N. variants: 3
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.360 Biomarker disease BEFREE We found that histamine induces growth-differentiation factor-15 in melanoma cell lines such as SK-MEL-2, B16F10, and melan-a cells. 22975449 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.360 Biomarker disease BEFREE This role in melanoma angiogenesis was confirmed by comparing MIC-1 and vascular endothelial growth factor (VEGF) function in chick chorioallantoic membrane and matrigel plug assays. 20431030 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.360 Biomarker disease LHGDN These results indicate that MIC-1 may function to promote development of more aggressive melanoma tumors. 18754039 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.360 AlteredExpression disease BEFREE Knockdown of MIC-1 expression using stable short-hairpin RNA in three melanoma cell lines showed a significant decrease in tumorigenicity (P<0.0001). 18754039 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.360 Biomarker disease BEFREE The elucidation of signaling pathways around MIC-1 might contribute to prospective targeting therapy for melanoma. 19148214 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.360 Biomarker disease BEFREE In addition, two other markers (PLAB and L1CAM) were evaluated for melanoma specificity but not for SLN analysis. 18982394 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.360 Biomarker disease CTD_human Epigenetic silencing of novel tumor suppressors in malignant melanoma. 17145863 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.360 GeneticVariation disease BEFREE Our study systematically identified novel melanoma-specific genes and showed the feasibility of using a combination of PLAB and L1CAM in a reverse transcription-PCR assay to differentiate clinically relevant samples containing benign or malignant melanocytes. 16243793 2005