CD38, CD38 molecule, 952

N. diseases: 473; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE We investigated the effects of six small molecule pharmacological agents, which interfere with endocytic and other processes, on SA-mediated augmentation of saporin and saporin-based immunotoxins (ITs) directed against CD7, CD19, CD22 and CD38 on human lymphoma and leukaemia cell lines. 30791598 2019
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE In clinics, CD38 was adopted as a cell activation marker and in the diagnostic/staging of leukemias. 31783629 2019
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression disease BEFREE TL and SKF inhibited chemotactic peptide fMLP-induced response linked to TRPV2 Ca<sup>2+</sup> activity, and down-regulated expression of surface marker CD38 involved in leukemia and lung airway inflammation. 30733502 2019
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression disease BEFREE The cells of CD34+ primary leukemia and CD38- KG-1, and TF-1 were separated by flow cytometry. 31307525 2019
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia. 27637890 2017
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE CD38 is both a positive and negative prognostic indicator in leukaemia. 29234114 2017
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Xenograft transplantation studies have demonstrated a rare population of leukemia-initiating cells called leukemic stem cells (LSCs) capable of propagating leukemia that are enriched in the CD34+/CD38- fraction. 27465508 2016
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE We previously showed that CD34⁺/CD38⁻ acute myelogenous leukemia (AML) cells, which contain leukemia stem cells, expressed a greater amount of the phosphorylated forms of JAK2 and STAT5 (p-JAK2 and p-STAT5) than their CD34⁺/CD38⁺ counterparts. 23564444 2013
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE We have also shown that CD34(+) /CD38(-) AML cells, one of compartments enriched for leukemia stem cells in most leukemia subgroups, were relatively resistant to cytarabine-mediated growth inhibition when compared to their CD34(+) /CD38(+) counterparts. 23686525 2013
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Although TET1 was first identified as a fusion partner of the mixed lineage leukemia (MLL) gene in acute myeloid leukemia carrying t(10,11), its definitive role in leukemia is unclear. 23818607 2013
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Relapse of acute myeloid leukemia (AML) is thought to reflect the failure of current therapies to adequately target leukemia stem cells (LSCs), the rare, resistant cells presumed responsible for maintenance of the leukemia and typically enriched in the CD34(+)CD38(-) cell population. 22262762 2012
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Importantly, peptide inhibition of BCL6 in human CML cells compromises colony formation and leukemia initiation in transplant recipients and selectively eradicates CD34(+) CD38(-) LICs in patient-derived CML samples. 21911423 2011
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML. 21330473 2011
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression disease BEFREE All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta. 21393419 2011
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease BEFREE The t(10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients. 20007546 2010
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE CD34(+)CD38(-)CD19(+), CD34(+)38(+)CD19(+), and CD34(-)CD38(+)CD19(+) fractions could self-renew and transfer the leukemia, whereas the CD34(-)CD38(+)CD19(+) fraction did not stably propagate in NOD/SCID mice. 20028384 2010
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE These data suggest that leukemia-initiating cells in childhood B-ALL have a primitive CD133(+)/CD19(-) and CD38(-) phenotype. 19147788 2009
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE CD38 is a powerful disease marker for human leukemias and myelomas, is directly involved in the pathogenesis and outcome of human immunodeficiency virus infection and chronic lymphocytic leukemia, and controls insulin release and the development of diabetes. 18626062 2008
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression disease LHGDN Retinoic acid-induced CD38 expression in HL-60 myeloblastic leukemia cells regulates cell differentiation or viability depending on expression levels. 16329108 2006
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease LHGDN IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL). 16642047 2006
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE No statistically significant differences were observed at diagnosis between patients with the CC genotype and homozygous or heterozygous T allele carriers with respect to age at disease onset, sex distribution, proportion of patients with CD38+ leukaemia or patients in Binet stage A, blood cell counts, degree of bone marrow infiltration or serum levels of lactate dehydrogenase, thymidine kinase or beta2-microglobulin. 14692527 2003
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease BEFREE To clarify the clinical features of t(10;11)-leukemias, we investigated 6 samples from acute leukemia patients with t(10;11) and MLL rearrangement and detected MLL-AF10 chimeric transcripts in 5 samples and MLL-ABI1 in one. 11477655 2001
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease BEFREE The t(10;11)(p13;q14-21) is a non-random translocation described in acute lymphoblastic and myeloid leukaemias. 11417476 2001
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease BEFREE Finally, CD34+/CD38- leukemia precursors, in contrast with CD38+ precursors, failed, under appropriate conditions, to differentiate into dendritic cells, a central step for antigen recognition. 10969785 2000
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease BEFREE The t(10;11)(p13;q14-21) is a non-random translocation that occurs primarily in T cell acute lymphoblastic leukemias (T-ALL), but has also been observed in leukemias and lymphomas of diverse lineages. 9737689 1998