leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of six small molecule pharmacological agents, which interfere with endocytic and other processes, on SA-mediated augmentation of saporin and saporin-based immunotoxins (ITs) directed against CD7, CD19, CD22 and CD38 on human lymphoma and leukaemia cell lines.
|
30791598 |
2019 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In clinics, CD38 was adopted as a cell activation marker and in the diagnostic/staging of leukemias.
|
31783629 |
2019 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TL and SKF inhibited chemotactic peptide fMLP-induced response linked to TRPV2 Ca<sup>2+</sup> activity, and down-regulated expression of surface marker CD38 involved in leukemia and lung airway inflammation.
|
30733502 |
2019 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The cells of CD34+ primary leukemia and CD38- KG-1, and TF-1 were separated by flow cytometry.
|
31307525 |
2019 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia.
|
27637890 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD38 is both a positive and negative prognostic indicator in leukaemia.
|
29234114 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Xenograft transplantation studies have demonstrated a rare population of leukemia-initiating cells called leukemic stem cells (LSCs) capable of propagating leukemia that are enriched in the CD34+/CD38- fraction.
|
27465508 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously showed that CD34⁺/CD38⁻ acute myelogenous leukemia (AML) cells, which contain leukemia stem cells, expressed a greater amount of the phosphorylated forms of JAK2 and STAT5 (p-JAK2 and p-STAT5) than their CD34⁺/CD38⁺ counterparts.
|
23564444 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have also shown that CD34(+) /CD38(-) AML cells, one of compartments enriched for leukemia stem cells in most leukemia subgroups, were relatively resistant to cytarabine-mediated growth inhibition when compared to their CD34(+) /CD38(+) counterparts.
|
23686525 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although TET1 was first identified as a fusion partner of the mixed lineage leukemia (MLL) gene in acute myeloid leukemia carrying t(10,11), its definitive role in leukemia is unclear.
|
23818607 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relapse of acute myeloid leukemia (AML) is thought to reflect the failure of current therapies to adequately target leukemia stem cells (LSCs), the rare, resistant cells presumed responsible for maintenance of the leukemia and typically enriched in the CD34(+)CD38(-) cell population.
|
22262762 |
2012 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, peptide inhibition of BCL6 in human CML cells compromises colony formation and leukemia initiation in transplant recipients and selectively eradicates CD34(+) CD38(-) LICs in patient-derived CML samples.
|
21911423 |
2011 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML.
|
21330473 |
2011 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta.
|
21393419 |
2011 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients.
|
20007546 |
2010 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD34(+)CD38(-)CD19(+), CD34(+)38(+)CD19(+), and CD34(-)CD38(+)CD19(+) fractions could self-renew and transfer the leukemia, whereas the CD34(-)CD38(+)CD19(+) fraction did not stably propagate in NOD/SCID mice.
|
20028384 |
2010 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that leukemia-initiating cells in childhood B-ALL have a primitive CD133(+)/CD19(-) and CD38(-) phenotype.
|
19147788 |
2009 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD38 is a powerful disease marker for human leukemias and myelomas, is directly involved in the pathogenesis and outcome of human immunodeficiency virus infection and chronic lymphocytic leukemia, and controls insulin release and the development of diabetes.
|
18626062 |
2008 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Retinoic acid-induced CD38 expression in HL-60 myeloblastic leukemia cells regulates cell differentiation or viability depending on expression levels.
|
16329108 |
2006 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL).
|
16642047 |
2006 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
No statistically significant differences were observed at diagnosis between patients with the CC genotype and homozygous or heterozygous T allele carriers with respect to age at disease onset, sex distribution, proportion of patients with CD38+ leukaemia or patients in Binet stage A, blood cell counts, degree of bone marrow infiltration or serum levels of lactate dehydrogenase, thymidine kinase or beta2-microglobulin.
|
14692527 |
2003 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To clarify the clinical features of t(10;11)-leukemias, we investigated 6 samples from acute leukemia patients with t(10;11) and MLL rearrangement and detected MLL-AF10 chimeric transcripts in 5 samples and MLL-ABI1 in one.
|
11477655 |
2001 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(10;11)(p13;q14-21) is a non-random translocation described in acute lymphoblastic and myeloid leukaemias.
|
11417476 |
2001 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, CD34+/CD38- leukemia precursors, in contrast with CD38+ precursors, failed, under appropriate conditions, to differentiate into dendritic cells, a central step for antigen recognition.
|
10969785 |
2000 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(10;11)(p13;q14-21) is a non-random translocation that occurs primarily in T cell acute lymphoblastic leukemias (T-ALL), but has also been observed in leukemias and lymphomas of diverse lineages.
|
9737689 |
1998 |