|
Autism Spectrum Disorders
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the two OT analogues had a remarkably long-acting effect, up to 16-24 h, on recovery from impaired social behaviors in two strains of CD38 knockout mice that exhibit autism spectrum disorder-like social behavioral deficits, whereas the effect of OT itself rapidly diminished.
|
30896946 |
2019 |
|
Autism Spectrum Disorders
|
0.100 |
Biomarker
|
disease |
BEFREE |
Decreased vitamin A, and its retinoic acid metabolites, lead to a decrease in CD38 and associated changes that underpin a wide array of data on the biological underpinnings of ASD, including decreased oxytocin, with relevance both prenatally and in the gut.
|
31682209 |
2019 |
|
Autism Spectrum Disorders
|
0.100 |
Biomarker
|
disease |
BEFREE |
A de novo CNV duplication was also identified in these twins overlapping CD38, a gene previously implicated in ASD.
|
30886340 |
2019 |
|
Autism Spectrum Disorders
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Oxytocin release via activation of TRPM2 and CD38 in the hypothalamus during hyperthermia in mice: Implication for autism spectrum disorder.
|
28736241 |
2018 |
|
Autism Spectrum Disorders
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD38 is reported as an autism spectrum disorder (ASD) candidate gene and its behavioral phenotypes may be linked to ASD.
|
29306053 |
2018 |
|
Autism Spectrum Disorders
|
0.100 |
Biomarker
|
disease |
BEFREE |
Network functional analysis showed that nodes controlled by miR-140-3p, especially CD38 and NRIP1 which are its validated targets, are involved in processes convergingly dysregulated in ASD, such as synaptic plasticity, immune response, and chromatin binding.
|
28848387 |
2017 |
|
Autism Spectrum Disorders
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this review, we summarize the current knowledge regarding associations between ASD and single-nucleotide variants of the human OXT-AVP pathway genes OXT, AVP, AVP receptor 1a (AVPR1a), OXT receptor (OXTR), the oxytocinase/vasopressinase (LNPEP), and ADP-ribosyl cyclase (CD38).
|
28283809 |
2017 |
|
Autism Spectrum Disorders
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It was expected that risk-allele-carriers of the oxytocin-receptor-gene-polymorphism (rs53576) and of CD38 (rs379863) responded similar to upright and inverted faces as persons with ASD.
|
27015428 |
2016 |
|
Autism Spectrum Disorders
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While a number of studies have implicated rare chromosomal deletions and duplications in helping determine genetic risk for autism, there are to our knowledge no reports describing rearrangements involving CD38 or deletions in patients with ASD.
|
24634087 |
2014 |
|
Autism Spectrum Disorders
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further analysis of CD38 in relation to the OXT system may provide a better understanding of the neuroendocrinological roles of OXT and CD38 in the hypothalamus and of the pathophysiology of ASD.
|
22227279 |
2012 |
|
Autism Spectrum Disorders
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hence, there is a rationale for investigating single nucleotide polymorphisms (SNPs) in the human CD38 gene in ASD subjects.We found several SNPs in this gene.
|
22366648 |
2012 |
|
Autism Spectrum Disorders
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, analysis of the role of genetic polymorphisms in the dynamics of the molecule revealed that the genotype of a single-nucleotide polymorphism (rs6449182; C>G variation) in the CpG island of intron 1, harboring the retinoic-acid response element, exerts differential roles in CD38 expression in ASD and in parental LBC.
|
21528155 |
2011 |
|
Autism Spectrum Disorders
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, we have shown that all-trans retinoic acid (ATRA), a known inducer of CD38 transcription, can rescue low CD38 expressing LBC lines derived from ASD subjects and restore normal levels of transcription of this ectoenzyme providing 'proof of principle' in a peripheral model that retinoids are potential therapeutic agents in ASD.
|
21557943 |
2011 |
|
Autism Spectrum Disorders
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SNPs of CD38, rs6449197 (p<0.040) and rs3796863 (p<0.005) showed significant associations with a subset of ASD (IQ>70; designated as high-functioning autism (HFA)) in the U.S. 104 AGRE family trios, but not with Japanese 188 HFA subjects.
|
20435366 |
2010 |
|
Autism Spectrum Disorders
|
0.100 |
Biomarker
|
disease |
BEFREE |
The current report supports a role for CD38 in conferring risk for ASD.
|
21182206 |
2010 |