Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Thus, targeting Mint3 in bone marrow-derived cells might be a good strategy for preventing metastasis and improving the prognosis of breast cancer patients.
|
28634075 |
2017 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Here, we report that APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth.
|
28507122 |
2017 |
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
The methylation status of the CpG island promoter region of TRGs related to melanoma pathophysiology (WIF1, TFPI2, RASSF1A, RARbeta2, SOCS1, and GATA4) and a panel of MINT loci (MINT1, MINT2, MINT3, MINT12, MINT17, MINT25, and MINT31) in primary and metastatic tumors of different clinical stages (n=122) was assessed.
|
19223509 |
2009 |
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we crossed conditional and constitutive Mint1, Mint2, and Mint3 knock-out mice with transgenic mouse models of Alzheimer's disease overproducing human Abeta peptides.
|
19118172 |
2008 |
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
LHGDN |
[Recent advances in Alzheimer's disease].
|
11831025 |
2001 |
Alzheimer's Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Determination of the APBA3 genome structure will facilitate the linkage analysis and search for mutations in the APBA3 in patients with Alzheimer's disease.
|
10574372 |
1999 |
Borderline Personality Disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
In the present study, we aimed to investigate the role of DNA methylation of APBA3 and MCF2 as possible biomarkers for treatment outcome in BPD, whilst validating the previous findings of differential DNA methylation in a cohort of 44 BPD patients and 44 well-matched healthy control individuals.
|
29274998 |
2018 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The mechanism by which APBA3 inhibition partially suppresses macrophage function and affects cancer metastasis is of interest in view of avoidance of the adverse effects of complete suppression of macrophage function during therapy.
|
28507122 |
2017 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
To address this, here we examined whether Mint3 depletion affects tumor malignancy in MMTV-PyMT breast cancer model mice.
|
28634075 |
2017 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
In MMTV-PyMT mice, Mint3 depletion did not affect tumor onset and tumor growth, but attenuated lung metastases.
|
28634075 |
2017 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
To address this, here we examined whether Mint3 depletion affects tumor malignancy in MMTV-PyMT breast cancer model mice.
|
28634075 |
2017 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The mechanism by which APBA3 inhibition partially suppresses macrophage function and affects cancer metastasis is of interest in view of avoidance of the adverse effects of complete suppression of macrophage function during therapy.
|
28507122 |
2017 |
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
A mutant Mint3 protein that cannot be phosphorylated exhibited a reduced ability to inhibit FIH-1 and promoted tumor formation in mice.
|
24164895 |
2014 |
Borderline Personality Disorder
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Bead chip technology and quantitative bisulfite pyrosequencing showed a significantly increased methylation at CpG sites of APBA2 (1.1 fold) and APBA3 (1.1 fold), KCNQ1 (1.5 fold), MCF2 (1.1 fold) and NINJ2 (1.2 fold) in BPD patients.
|
24367640 |
2013 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, targeting Mint3 in bone marrow-derived cells might be a good strategy for preventing metastasis and improving the prognosis of breast cancer patients.
|
28634075 |
2017 |
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further bone marrow transplant experiments revealed that Mint3 in bone marrow-derived cells promoted lung metastasis in MMTV-PyMT mice.
|
28634075 |
2017 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, targeting Mint3 in bone marrow-derived cells might be a good strategy for preventing metastasis and improving the prognosis of breast cancer patients.
|
28634075 |
2017 |