|
Obesity
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
SDC3 rs2282440 TT homozygote had a 1.96-fold risk of being obese and 1.8-fold risk of having MetS (with CC genotype as reference).
|
29666642 |
2018 |
|
Obesity
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
As female obesity is associated with hyperandrogenism and infertility, we studied the role of SDC3 polymorphisms in female individuals undergoing diagnostics prior to infertility treatment.
|
19820907 |
2009 |
|
Obesity
|
0.440 |
AlteredExpression
|
disease |
BEFREE |
As part of this review, we will highlight how syndecan-3 can mediate the activity of adiposity signals, such as leptin, and facilitate changes in neuronal plasticity.
|
17698399 |
2008 |
|
Obesity
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Of three SNPs in SDC3, rs4949184 was not associated with obesity and the other two SNPs (rs2282440 and rs2491132) were strongly associated with obesity (P < 0.0001), and the results were confirmed in the second independent study group.
|
17018662 |
2006 |
|
Obesity
|
0.440 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Obesity
|
0.440 |
Biomarker
|
disease |
HPO |
|
|
|
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
OBESITY, ASSOCIATION WITH
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Decreased resting energy expenditure
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Increased waist to hip ratio
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using in vitro and in vivo models, soluble syndecan-3 inhibited leukocyte migration in vitro in response to CCL7 and its administration in murine models of rheumatoid arthritis reduced histological disease severity.
|
31300004 |
2019 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Among these targets, expression of SDC3 was directly controlled by miR-144-5p, and its expression enhanced cancer cell aggressiveness.
|
29968393 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Among these targets, expression of SDC3 was directly controlled by miR-144-5p, and its expression enhanced cancer cell aggressiveness.
|
29968393 |
2018 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The expression rates of PTN and N-syndecan proteins were 66.7% and 61.1%, respectively, in cancer tissue.
|
28638231 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
High PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and PNI in the orthotopic mouse model of pancreatic cancer.
|
28638231 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The expression rates of PTN and N-syndecan proteins were 66.7% and 61.1%, respectively, in cancer tissue.
|
28638231 |
2017 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The expression of GFRα1 and GFRα3, but not SDC3, was significantly increased in mammary carcinoma and positively associated with tumor lymph node metastases, higher clinical stage and HER-2 positivity.
|
23351331 |
2013 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Despite the fact that many published reports focused on the role of pleiotrophin and its receptors, receptor protein tyrosine phosphatase (RPTPβ/ζ), and syndecan-3 during tumor development, no information is available regarding their function in tumor metastasis.
|
23060448 |
2012 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Despite the fact that many published reports focused on the role of pleiotrophin and its receptors, receptor protein tyrosine phosphatase (RPTPβ/ζ), and syndecan-3 during tumor development, no information is available regarding their function in tumor metastasis.
|
23060448 |
2012 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, RT-PCR showed the presence of syndecan-3 messenger RNA in endothelial cells extracted from RA and nonrheumatoid synovia.
|
16052590 |
2005 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
LHGDN |
Induction of a CXCL8 binding site on endothelial syndecan-3 in rheumatoid synovium.
|
16052590 |
2005 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Colocalization of amyloid plaques with members of the syndecan family of HSPGs, along with the increased expression of syndecan-3 and -4 have already been reported in postmortem AD brains.
|
30718543 |
2019 |
|
Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, soluble syndecan-3 occurred naturally in the sera of patients with rheumatoid arthritis and periodontitis, and its levels correlated with syndecan-1.
|
31300004 |
2019 |
|
Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Syndecan-3 and 4 also triggered fibrillation of Aβ1-42, further emphasizing the pathophysiological relevance of syndecans in plaque formation.
|
30718543 |
2019 |
|
Familial Alzheimer Disease (FAD)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significant differential expression of ErbB4, SCNB1, and Tie1 in lesional skin was specific to Hidradenitis Suppurativa and EphB2, EPHB4, KCNE1, LRP6, MUSK, SDC3, Sortilin1 in blood specific to Familial Alzheimer's Disease.
|
31608281 |
2019 |