ARHGAP32, Rho GTPase activating protein 32, 9743

N. diseases: 11; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET These results suggest that a genetic variation in the p250GAP gene might increase susceptibility not only for schizophrenia but also for schizotypal personality traits. 22530067 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 GeneticVariation disease BEFREE These results suggest that a genetic variation in the p250GAP gene might increase susceptibility not only for schizophrenia but also for schizotypal personality traits. 22530067 2012
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.210 GeneticVariation disease BEFREE We identify novel DN LGD recurrences (GIGYF2, MYT1L, CUL3, DOCK8 and ZNF292) and DN mutations in previous ASD candidates (ARHGAP32, NCOR1, PHIP, STXBP1, CDKL5 and SHANK1). 27824329 2016
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.210 Biomarker disease MGD
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm 		0.100 GeneticVariation disease GWASCAT Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population. 30823506 2019
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.020 Biomarker disease BEFREE Our results suggest that PX-RICS-mediated GABA<sub>A</sub>R trafficking is a key target for GABAergic plasticity and its dysfunction leads to atypical emotional processing underlying autism. 30045817 2018
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.020 Biomarker disease BEFREE The findings from three additional patients with autistic features and "atypical" distal 11q deletions led to the identification of an autism "critical region" in distal 11q containing four annotated genes including ARHGAP32 (also known as RICS), a gene encoding rho GTPase activating protein. 25058499 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE Rac GTPase-activating protein (RacGAP) 1 plays a key role in controlling various cellular phenomena including cytokinesis, transformation, invasive migration and metastasis. 25568185 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 Biomarker phenotype BEFREE RACGAP1 is a Rac GTPase-activating protein involved in cell growth regulation, cell transformation and metastasis. 23096218 2013
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.010 AlteredExpression phenotype BEFREE This study indicated that the learning and memory impairment and the decrease of dendritic spine density in the offspring of LaCl<sub>3</sub> exposure may be related to the down-regulation of the Rac1/PAK signaling pathway regulated by Tiam1 and p250GAP. 31776842 2020
CUI: C0542476
Disease: Forgetful
Forgetful 		0.010 AlteredExpression phenotype BEFREE This study indicated that the learning and memory impairment and the decrease of dendritic spine density in the offspring of LaCl<sub>3</sub> exposure may be related to the down-regulation of the Rac1/PAK signaling pathway regulated by Tiam1 and p250GAP. 31776842 2020
CUI: C0281902
Disease: maladjustment
maladjustment 		0.010 Biomarker phenotype BEFREE Conscientiousness and self-control were found to be positively correlated with grit factors and they had negative effects on academic maladjustment through perseverance of effort. 29298549 2018
CUI: C0002020
Disease: Alexithymia
Alexithymia 		0.010 Biomarker phenotype BEFREE From our analysis, variants in the genes ABCB4, TP53AIP1, ARHGAP32 and TMEM88B were identified linked to the alexithymia phenotype. 25882097 2015
CUI: C0036363
Disease: Schizotypal Personality Disorder
Schizotypal Personality Disorder 		0.010 GeneticVariation disease BEFREE These results suggest that a genetic variation in the p250GAP gene might increase susceptibility not only for schizophrenia but also for schizotypal personality traits. 22530067 2012