Nephrogenic Diabetes Insipidus
|
0.200 |
Biomarker
|
disease |
RGD |
E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal.
|
21734099 |
2011 |
Retinoblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
A stable cell line was established from MCF10AT3B cells that ectopically expresses the retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46), a component of the histone modifying and remodeling complexes.
|
17970062 |
2007 |
Retinoblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46) is a member of the WD-repeat protein family and a component of the histone modifying and remodeling complexes.
|
11394910 |
2001 |
Retinoblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46) is a nuclear protein of the WD-repeat protein family and a component of the histone deacetylase complex that physically interacts with Rb.
|
11433396 |
2001 |
Retinoblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The gene was identified as retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46), a nuclear protein that interacts physically with Rb and is a component of the human mSin3 co-repressor complex.
|
9765217 |
1998 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.
|
30321325 |
2019 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We evaluated the effects of RNF40 depletion in several human CRC cell lines in vitro.
|
31266541 |
2019 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
An exciting really interesting new gene (RING) family of E3 ubiquitin ligases, known as RNF20 and RNF40, monoubiquitinates histone H2A at K119 or H2B at K120, is known to function in transcriptional elongation, DNA double-strand break (DSB) repair processes, maintenance of chromatin differentiation, and exerting tumor suppressor activity.
|
29934362 |
2018 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We found that RNF20 and RNF40 expression and global H2Bub1 are relatively low, and USP44 expression is relatively high, in basal-like breast tumors compared with luminal tumors.
|
28157208 |
2017 |
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we examined the effect of a colon-specific loss of Rnf40 in a murine model of colitis, and assessed both local and systemic inflammation-associated consequences.
|
30321325 |
2019 |
Acute colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Consistently, the colon-specific loss of Rnf40 exerted a protective local, as well as systemic, effect following acute colitis.
|
30321325 |
2019 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.
|
30321325 |
2019 |
Tumor Progression
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The PHKG2 and RNF40 genes are either overlapping or close to the sequences of SCAR marker BC13-4, while SCAR marker BC10-1 is in the intron and overlap the DPEP1 gene, suggesting that alterations in the expression of these genes could contribute to cancer progression.
|
28410206 |
2017 |
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We found that RNF20 and RNF40 expression and global H2Bub1 are relatively low, and USP44 expression is relatively high, in basal-like breast tumors compared with luminal tumors.
|
28157208 |
2017 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We now report that the chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation (H2Bub1), modulates inflammation and inflammation-associated cancer in mice and humans.
|
26854224 |
2016 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
We now report that the chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation (H2Bub1), modulates inflammation and inflammation-associated cancer in mice and humans.
|
26854224 |
2016 |
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
RNF40 is located at 16p11.2, a region implicated in autism and schizophrenia.
|
21647175 |
2012 |
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
RNF40 is located at 16p11.2, a region implicated in autism and schizophrenia.
|
21647175 |
2012 |
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.
|
22155569 |
2012 |
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.
|
22155569 |
2012 |
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition.
|
9765217 |
1998 |
Childhood Kidney Wilms Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition.
|
9765217 |
1998 |