MFN2, mitofusin 2, 9927

N. diseases: 334; N. variants: 75
Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.240 Biomarker group BEFREE Among the factors that modulate hypertension are endoplasmic reticulum stress and vascular smooth muscle cell proliferation which are in turn modulated by mitofusion-2 (Mfn2). 30940795 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.240 Therapeutic group RGD Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. 27847271 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.240 Biomarker group BEFREE So we inferred that the Mfn2 gene may participate in the pathogenesis of hypertension. 26816493 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.240 Biomarker group RGD Mitofusin 2 ameliorates aortic remodeling by suppressing ras/raf/ERK pathway and regulating mitochondrial function in vascular smooth muscle cells. 25464244 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.240 GeneticVariation group BEFREE 5'-UCR -1248 A>G variation of Mfn2/HSG gene was a novel variation and may be associated with hypertension in Chinese. 23549803 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.240 Biomarker group BEFREE In this study, 542 normotensive subjects (NT group) and 539 hypertensive patients (EH group) were screened for an association study between HSG/Mfn2 and hypertension. 20940517 2011