Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TP53, NOTCH1, CASP8, CDKN2A, and CDH1 are the most frequently mutated genes in OSCC patients.
|
30041611 |
2018 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We observed that CDH1 methylation is significantly correlated with decreased CDH1 protein expression in eyelid SCC patients.
|
26790440 |
2016 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We show that the loss of both Cdh1 and Tgfbr2 in both models is sufficient to induce squamous cell carcinomas with animals succumbing to the invasive disease by 18 months of age.
|
25233932 |
2014 |
Squamous cell carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Quantitative methylation-specific PCR analysis showed a significant increase in promoter hypermethylation of p16 and CDH1 in OSCC tumors relative to paired non-tumorous tissues.
|
20729138 |
2010 |
Squamous cell carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
LHGDN |
Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only.
|
19148529 |
2009 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas.
|
18197935 |
2008 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas.
|
18197935 |
2008 |
Squamous cell carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
LHGDN |
CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma.
|
18697202 |
2008 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis.
|
18097581 |
2008 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features.
|
18327819 |
2008 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The study of E-cadherine and CD44 immunoexpression in oral squamous cell carcinoma.
|
18516325 |
2008 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma.
|
17520682 |
2007 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion.
|
17203182 |
2007 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma.
|
17647062 |
2007 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Loss of intercellular adhesion activates a transition from low- to high-grade human squamous cell carcinoma.
|
16152579 |
2006 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC).
|
16761612 |
2006 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma.
|
16426911 |
2006 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that the promoter hypermethylation of cancer-related genes, especially CDH1, is frequently shown in SCCs, and dysregulation of the RB1/p16 and/or p53 pathway through either genetic or epigenetic mechanisms, except for epigenetic abnormalities of p53 itself, should contribute to the carcinogenesis of SCCs.
|
17034532 |
2006 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
E-cadherin is a selective and strongly dominant prognostic factor in squamous cell carcinoma: a comparison of E-cadherin with desmosomal components.
|
15609307 |
2005 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Twenty-two laryngeal squamous cell carcinomas were analyzed in our study regarding genetic changes of two tumor suppressor genes: Adenomatous polyposis coli (APC) and E-cadherin (CDH1).
|
16259108 |
2005 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin.
|
15328184 |
2004 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, methylation of the 5' CpG island in the E-cadherin promoter induces reciprocal expression of E- and N-cadherins in oral SCC by an unknown mechanism that appears to be mediated at the level of N-cadherin gene expression.
|
14985090 |
2004 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue.
|
14734465 |
2004 |
Squamous cell carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Promoter hypermethylation of the E-cadherin gene was detected in 6 of 7 cases (85%) of invasive squamous cell carcinoma, 4 of 8 cases (50%) of squamous cell carcinoma in situ, 4 of 9 cases (44%) of actinic keratosis, and 2 of 9 cases (22%) of nonneoplastic skin.
|
14559984 |
2003 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma: relationships with prognosis.
|
12532436 |
2003 |