Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations.
|
31077828 |
2020 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer.
|
30168144 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The poorly cohesive histology/CDH1-mutant GC subgroup showed the worst survival (p < 0.001).
|
30801717 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The cumulative incidence of gastric cancer for individuals with pathogenic variants in CDH1 is significantly lower than previously described.
|
31246251 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer.
|
30642281 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
CDH1 hypermethylation status was found to be associated with advancement of disease, distant organ metastases and lymph node invasion in Gastric cancer patients.
|
30989488 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of circFNDC3B reduced the level of E-cadherin protein to promote the epithelial-mesenchymal transition in GC.
|
30963578 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate that germline CDH1 mutations are a significant contributor to the high frequency of diffuse gastric cancer in New Zealand Māori.
|
29589180 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
CDH1a, a non-canonical transcript of the CDH1 gene, has been found to be expressed in some gastric cancer (GC) cell lines, whereas it is absent in normal gastric mucosa.
|
29443099 |
2018 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We identified a new truncating germline mutation (p.Asp538Thrfs*19) in exon 11 of the CDH1 gene in a 41-year-old male with a diffuse gastric cancer.
|
29131691 |
2018 |
Malignant neoplasm of stomach
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that CDH1, cyclooxygenase-2 and matrix metalloproteinase genes had significantly higher expression levels, whereas the expression levels of dermatopontin and transforming growth factor β receptor 2 were decreased in GC samples.
|
29434905 |
2018 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the CDH1 gene are linked both to diffuse gastric cancer and invasive lobular carcinoma (ILC).
|
28993866 |
2018 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
HDGC, which is mainly caused by germline mutations in the E-cadherin gene (CDH1), renders a lifetime risk of gastric cancer of up to 70%, prompting a recommendation for prophylactic total gastrectomy.
|
27759617 |
2017 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis.
|
28024868 |
2017 |
Malignant neoplasm of stomach
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
For the first time, we evaluated by digital PCR the expression of CDH1 and CDH1a transcripts in cancer and normal tissue samples from 32 patients with intestinal-type gastric cancer.
|
27861150 |
2017 |
Malignant neoplasm of stomach
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, methylation of the CDH1 gene in AM may be a surrogate of GC.
|
29042646 |
2017 |
Malignant neoplasm of stomach
|
0.800 |
Biomarker
|
disease |
BEFREE |
It is implied that TRERNA1/CDH1 is a new potential target for GC therapy.
|
28918030 |
2017 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Female predominance in early-onset gastric cancer may be related to relatively high rates of somatic CDH1 and TGFBR1 mutations in this population.
|
28522256 |
2017 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The <i>CDH1</i> gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion.
|
29295527 |
2017 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results.
|
27706737 |
2016 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the CDH1 c.1679C>G (p.T560R) variant segregated with gastric cancer in all three family members affected with gastric cancer in this family.
|
27880784 |
2016 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Germline E-cadherin/CDH1 mutations have been identified in families with an autosomal dominant inherited predisposition to diffuse gastric cancer.
|
27899187 |
2016 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This study was aimed to analyse the hypermethylation status of the E-Cadherin (CDH1) gene promoter in GCs in the ethnic Kashmiri population.
|
27356686 |
2016 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
All individuals with a CDH1 mutation had a personal or family history of diffuse gastric cancer.
|
26072394 |
2015 |