SIRT1, sirtuin 1, 23411

N. diseases: 675; N. variants: 21
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs7096385
rs7096385 		1.000 0.080 10 67905124 intron variant T/C;G snv
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases 0.700 1.000 1 2018 2018
dbSNP: rs3758391
rs3758391 		0.742 0.480 10 67883584 upstream gene variant T/C snv 0.64
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		Nutritional and Metabolic Diseases; Endocrine System Diseases 0.030 0.667 3 2010 2020
dbSNP: rs7896005
rs7896005 		0.925 0.080 10 67891367 intron variant A/G;T snv 0.52; 8.0E-06 0.47
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		Nutritional and Metabolic Diseases; Endocrine System Diseases 0.030 1.000 3 2011 2020
dbSNP: rs10823108
rs10823108 		0.925 0.160 10 67900736 intron variant G/A snv 7.1E-02
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases 0.020 1.000 2 2017 2018
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0032000
Disease: Pituitary Adenoma
Pituitary Adenoma 		Neoplasms; Nervous System Diseases; Endocrine System Diseases 0.020 1.000 2 2017 2019
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		Eye Diseases 0.020 1.000 2 2015 2019
dbSNP: rs1467568
rs1467568 		0.776 0.320 10 67915401 intron variant A/G snv 0.46
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		Cardiovascular Diseases 0.020 1.000 2 2017 2018
dbSNP: rs2273773
rs2273773 		0.790 0.360 10 67906841 synonymous variant T/C snv 0.11 7.1E-02
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		Cardiovascular Diseases 0.020 1.000 2 2011 2015
dbSNP: rs7069102
rs7069102 		0.790 0.440 10 67903362 intron variant C/G snv 0.64
CUI: C0028754
Disease: Obesity
Obesity 		Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases 0.020 1.000 2 2008 2011
dbSNP: rs10823108
rs10823108 		0.925 0.160 10 67900736 intron variant G/A snv 7.1E-02
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		Nutritional and Metabolic Diseases; Endocrine System Diseases 0.010 1.000 1 2017 2017
dbSNP: rs10997870
rs10997870 		1.000 0.040 10 67908257 intron variant G/T snv 0.47
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs10997870
rs10997870 		1.000 0.040 10 67908257 intron variant G/T snv 0.47
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		Behavior and Behavior Mechanisms 0.010 1.000 1 2016 2016
dbSNP: rs10997871
rs10997871 		0.925 0.080 10 67913178 intron variant T/C snv 4.1E-03
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2019 2019
dbSNP: rs10997871
rs10997871 		0.925 0.080 10 67913178 intron variant T/C snv 4.1E-03
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.010 1.000 1 2019 2019
dbSNP: rs10997871
rs10997871 		0.925 0.080 10 67913178 intron variant T/C snv 4.1E-03
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2019 2019
dbSNP: rs11599176
rs11599176 		0.925 0.080 10 67894017 intron variant A/G snv 0.11
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		Digestive System Diseases 0.010 1.000 1 2018 2018
dbSNP: rs11599176
rs11599176 		0.925 0.080 10 67894017 intron variant A/G snv 0.11
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		Digestive System Diseases; Chemically-Induced Disorders 0.010 1.000 1 2018 2018
dbSNP: rs12413112
rs12413112 		1.000 0.040 10 67892108 intron variant G/A snv 0.11
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		Cardiovascular Diseases 0.010 1.000 1 2018 2018
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		Skin and Connective Tissue Diseases; Immune System Diseases 0.010 1.000 1 2014 2014
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0206172
Disease: Diabetic Foot
Diabetic Foot 		Skin and Connective Tissue Diseases; Endocrine System Diseases; Cardiovascular Diseases 0.010 1.000 1 2018 2018
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		Digestive System Diseases; Neoplasms 0.010 1.000 1 2018 2018
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		Neoplasms; Skin and Connective Tissue Diseases 0.010 1.000 1 2016 2016
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		Nervous System Diseases 0.010 1.000 1 2019 2019
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		Digestive System Diseases; Neoplasms 0.010 1.000 1 2018 2018
dbSNP: rs12778366
rs12778366 		0.724 0.480 10 67883321 upstream gene variant T/C;G snv
CUI: C0280324
Disease: Laryngeal Squamous Cell Carcinoma
Laryngeal Squamous Cell Carcinoma 		Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases 0.010 1.000 1 2019 2019