OPRK1, opioid receptor kappa 1, 4986

N. diseases: 156; N. variants: 12
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs1051660
rs1051660 		1.000 0.080 8 53251002 synonymous variant C/A;T snv 0.11
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		Pathological Conditions, Signs and Symptoms; Neoplasms 0.010 < 0.001 1 2017 2017
dbSNP: rs1051660
rs1051660 		1.000 0.080 8 53251002 synonymous variant C/A;T snv 0.11
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2007 2007
dbSNP: rs1051660
rs1051660 		1.000 0.080 8 53251002 synonymous variant C/A;T snv 0.11
CUI: C0030193
Disease: Pain
Pain 		Pathological Conditions, Signs and Symptoms 0.010 < 0.001 1 2017 2017
dbSNP: rs10958350
rs10958350 		8 53237506 intron variant G/A;T snv
CUI: C3887611
Disease: Restlessness
Restlessness 		Behavior and Behavior Mechanisms 0.010 1.000 1 2014 2014
dbSNP: rs10958350
rs10958350 		8 53237506 intron variant G/A;T snv
CUI: C0085631
Disease: Agitation
Agitation 		Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms 0.010 1.000 1 2014 2014
dbSNP: rs16918875
rs16918875 		8 53229594 synonymous variant G/A snv 4.3E-02 7.1E-02
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2012 2012
dbSNP: rs6473797
rs6473797 		0.925 0.080 8 53240422 intron variant T/C snv 0.39
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2020 2020
dbSNP: rs6473797
rs6473797 		0.925 0.080 8 53240422 intron variant T/C snv 0.39
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2018 2018
dbSNP: rs6473799
rs6473799 		8 53240563 intron variant A/G snv 0.39
CUI: C0030193
Disease: Pain
Pain 		Pathological Conditions, Signs and Symptoms 0.010 1.000 1 2016 2016
dbSNP: rs6473799
rs6473799 		8 53240563 intron variant A/G snv 0.39
CUI: C0241136
Disease: Pain of skin
Pain of skin 		Pathological Conditions, Signs and Symptoms 0.010 1.000 1 2013 2013
dbSNP: rs6985606
rs6985606 		0.882 0.080 8 53248556 intron variant T/C snv 0.63
CUI: C0338777
Disease: Opium Dependence
Opium Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2018 2018
dbSNP: rs6985606
rs6985606 		0.882 0.080 8 53248556 intron variant T/C snv 0.63
CUI: C0856561
Disease: Opium addiction
Opium addiction 		0.010 1.000 1 2018 2018
dbSNP: rs6985606
rs6985606 		0.882 0.080 8 53248556 intron variant T/C snv 0.63
CUI: C0917801
Disease: Sleeplessness
Sleeplessness 		Nervous System Diseases; Mental Disorders 0.010 1.000 1 2018 2018
dbSNP: rs6985606
rs6985606 		0.882 0.080 8 53248556 intron variant T/C snv 0.63
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2018 2018
dbSNP: rs7016778
rs7016778 		8 53237545 intron variant A/T snv 0.17
CUI: C0030193
Disease: Pain
Pain 		Pathological Conditions, Signs and Symptoms 0.010 1.000 1 2013 2013
dbSNP: rs7016778
rs7016778 		8 53237545 intron variant A/T snv 0.17
CUI: C0085631
Disease: Agitation
Agitation 		Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms 0.010 1.000 1 2014 2014
dbSNP: rs7016778
rs7016778 		8 53237545 intron variant A/T snv 0.17
CUI: C3887611
Disease: Restlessness
Restlessness 		Behavior and Behavior Mechanisms 0.010 1.000 1 2014 2014
dbSNP: rs702764
rs702764 		0.925 0.120 8 53229597 synonymous variant T/C;G snv 0.17; 8.0E-06
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2012 2012
dbSNP: rs702764
rs702764 		0.925 0.120 8 53229597 synonymous variant T/C;G snv 0.17; 8.0E-06
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.010 < 0.001 1 2018 2018
dbSNP: rs702764
rs702764 		0.925 0.120 8 53229597 synonymous variant T/C;G snv 0.17; 8.0E-06
CUI: C0021122
Disease: Disruptive, Impulse Control, and Conduct Disorders
Disruptive, Impulse Control, and Conduct Disorders 		Mental Disorders 0.010 1.000 1 2018 2018
dbSNP: rs702764
rs702764 		0.925 0.120 8 53229597 synonymous variant T/C;G snv 0.17; 8.0E-06
CUI: C0027609
Disease: Neonatal Abstinence Syndrome
Neonatal Abstinence Syndrome 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2015 2015
dbSNP: rs751416416
rs751416416 		0.882 0.120 8 53250920 missense variant C/A;T snv 8.3E-06; 4.1E-06
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2012 2012
dbSNP: rs751416416
rs751416416 		0.882 0.120 8 53250920 missense variant C/A;T snv 8.3E-06; 4.1E-06
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2017 2017
dbSNP: rs751416416
rs751416416 		0.882 0.120 8 53250920 missense variant C/A;T snv 8.3E-06; 4.1E-06
CUI: C0030193
Disease: Pain
Pain 		Pathological Conditions, Signs and Symptoms 0.010 1.000 1 2019 2019
dbSNP: rs751416416
rs751416416 		0.882 0.120 8 53250920 missense variant C/A;T snv 8.3E-06; 4.1E-06
CUI: C0438696
Disease: Suicidal
Suicidal 		Behavior and Behavior Mechanisms 0.010 1.000 1 2019 2019