PDYN, prodynorphin, 5173

N. diseases: 197; N. variants: 13
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs267606939
rs267606939 		1.000 0.080 20 1980445 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C1853250
Disease: SPINOCEREBELLAR ATAXIA 23
SPINOCEREBELLAR ATAXIA 23 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases 0.800 1.000 5 2010 2013
dbSNP: rs267606940
rs267606940 		1.000 0.080 20 1980456 missense variant A/G snv 2.0E-05 1.4E-05
CUI: C1853250
Disease: SPINOCEREBELLAR ATAXIA 23
SPINOCEREBELLAR ATAXIA 23 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases 0.800 1.000 5 2010 2013
dbSNP: rs267606941
rs267606941 		1.000 0.080 20 1980674 missense variant C/A snv 5.6E-05 7.7E-05
CUI: C1853250
Disease: SPINOCEREBELLAR ATAXIA 23
SPINOCEREBELLAR ATAXIA 23 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases 0.800 1.000 5 2010 2013
dbSNP: rs201486601
rs201486601 		1.000 0.080 20 1980454 missense variant G/A snv 3.6E-05 2.1E-05
CUI: C1853250
Disease: SPINOCEREBELLAR ATAXIA 23
SPINOCEREBELLAR ATAXIA 23 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases 0.800 1.000 1 2010 2010
dbSNP: rs575606358
rs575606358 		1.000 0.080 20 1980472 missense variant G/A snv 1.2E-04 6.3E-05
CUI: C1853250
Disease: SPINOCEREBELLAR ATAXIA 23
SPINOCEREBELLAR ATAXIA 23 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases 0.700 1.000 4 2010 2013
dbSNP: rs1004881058
rs1004881058 		1.000 0.080 20 1980471 missense variant C/T snv 8.0E-06 7.0E-06
CUI: C1853250
Disease: SPINOCEREBELLAR ATAXIA 23
SPINOCEREBELLAR ATAXIA 23 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases 0.700 0
dbSNP: rs773876922
rs773876922 		1.000 0.080 20 1983020 missense variant C/T snv 1.6E-05 4.2E-05
CUI: C1853250
Disease: SPINOCEREBELLAR ATAXIA 23
SPINOCEREBELLAR ATAXIA 23 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases 0.700 0
dbSNP: rs1997794
rs1997794 		0.851 0.120 20 1994212 5 prime UTR variant T/C snv 0.50
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.030 0.667 3 2009 2019
dbSNP: rs1997794
rs1997794 		0.851 0.120 20 1994212 5 prime UTR variant T/C snv 0.50
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		Chemically-Induced Disorders; Mental Disorders 0.020 1.000 2 2013 2018
dbSNP: rs2235751
rs2235751 		0.882 0.120 20 1989288 intron variant A/G snv 0.40
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		Chemically-Induced Disorders; Mental Disorders 0.020 1.000 2 2013 2017
dbSNP: rs2281285
rs2281285 		0.925 0.080 20 1991814 intron variant T/C snv 0.16
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		Chemically-Induced Disorders; Mental Disorders 0.020 1.000 2 2013 2015
dbSNP: rs910080
rs910080 		0.851 0.120 20 1979580 3 prime UTR variant A/G snv 0.35
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.020 1.000 2 2018 2019
dbSNP: rs1280296282
rs1280296282 		1.000 0.080 20 1982967 missense variant T/C snv 4.0E-06 1.4E-05
CUI: C0600241
Disease: heroin abuse
heroin abuse 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2006 2006
dbSNP: rs1997794
rs1997794 		0.851 0.120 20 1994212 5 prime UTR variant T/C snv 0.50
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		Nervous System Diseases; Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1997794
rs1997794 		0.851 0.120 20 1994212 5 prime UTR variant T/C snv 0.50
CUI: C0497327
Disease: Dementia
Dementia 		Nervous System Diseases; Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs2235749
rs2235749 		0.790 0.200 20 1979293 3 prime UTR variant G/A snv 0.37
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		Digestive System Diseases; Neoplasms 0.010 < 0.001 1 2014 2014
dbSNP: rs2235749
rs2235749 		0.790 0.200 20 1979293 3 prime UTR variant G/A snv 0.37
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		Chemically-Induced Disorders; Mental Disorders 0.010 < 0.001 1 2019 2019
dbSNP: rs2235749
rs2235749 		0.790 0.200 20 1979293 3 prime UTR variant G/A snv 0.37
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs2235749
rs2235749 		0.790 0.200 20 1979293 3 prime UTR variant G/A snv 0.37
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2011 2011
dbSNP: rs2235749
rs2235749 		0.790 0.200 20 1979293 3 prime UTR variant G/A snv 0.37
CUI: C0086025
Disease: Codependency
Codependency 		Behavior and Behavior Mechanisms 0.010 1.000 1 2009 2009
dbSNP: rs2235749
rs2235749 		0.790 0.200 20 1979293 3 prime UTR variant G/A snv 0.37
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		Digestive System Diseases; Neoplasms 0.010 < 0.001 1 2014 2014
dbSNP: rs2235749
rs2235749 		0.790 0.200 20 1979293 3 prime UTR variant G/A snv 0.37
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs2235751
rs2235751 		0.882 0.120 20 1989288 intron variant A/G snv 0.40
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		Nervous System Diseases; Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs2235751
rs2235751 		0.882 0.120 20 1989288 intron variant A/G snv 0.40
CUI: C0497327
Disease: Dementia
Dementia 		Nervous System Diseases; Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs2281285
rs2281285 		0.925 0.080 20 1991814 intron variant T/C snv 0.16
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2015 2015