Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0002395
Disease:
Alzheimer's Disease
0.900 GeneticVariation BEFREE (2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI  = 4.03 × 10(-05), pBMI corr  = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI  = 0.002, rs2075650 at TOMM40/APOE, pBMI  = 0.024, rs3865444 at CD33, pBMI  = 0.024). 24788522 2014
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0028754
Disease:
Obesity
0.010 GeneticVariation BEFREE (2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI  = 4.03 × 10(-05), pBMI corr  = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI  = 0.002, rs2075650 at TOMM40/APOE, pBMI  = 0.024, rs3865444 at CD33, pBMI  = 0.024). 24788522 2014
dbSNP: rs1160985
rs1160985
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement
T 0.800 GeneticVariation GWASCAT A genome wide association study identifies common variants associated with lipid levels in the Chinese population. 24386095 2013
dbSNP: rs1160985
rs1160985
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C1445957
Disease:
Serum total cholesterol measurement
T 0.800 GeneticVariation GWASDB A genome wide association study identifies common variants associated with lipid levels in the Chinese population. 24386095 2013
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0234985
Disease:
Mental deterioration
G 0.800 GeneticVariation GWASDB A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. 23207651 2014
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0234985
Disease:
Mental deterioration
G 0.800 GeneticVariation GWASCAT A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. 23207651 2014
dbSNP: rs8106922
rs8106922
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement
A 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1038026
rs1038026
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0392885
Disease:
High density lipoprotein measurement
A 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1038026
rs1038026
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement
A 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs157588
rs157588
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0392885
Disease:
High density lipoprotein measurement
C 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs157588
rs157588
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement
C 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs8106922
rs8106922
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C1445957
Disease:
Serum total cholesterol measurement
A 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C1305855
Disease:
Body mass index
A 0.700 GeneticVariation GWASCAT A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci. 30108127 2018
dbSNP: rs10524523
rs10524523
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0002395
Disease:
Alzheimer's Disease
0.100 GeneticVariation BEFREE A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD). 23333464 2013
dbSNP: rs10524523
rs10524523
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset
0.080 GeneticVariation BEFREE A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset. 21784354 2011
dbSNP: rs10524523
rs10524523
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset
0.080 GeneticVariation BEFREE A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. 28768149 2017
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0002395
Disease:
Alzheimer's Disease
0.900 GeneticVariation GWASDB ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. 24770881 2014
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0002395
Disease:
Alzheimer's Disease
0.900 GeneticVariation GWASCAT ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. 24770881 2014
dbSNP: rs11556505
rs11556505
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0002395
Disease:
Alzheimer's Disease
0.700 GeneticVariation GWASDB ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. 24770881 2014
dbSNP: rs34404554
rs34404554
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0002395
Disease:
Alzheimer's Disease
0.700 GeneticVariation GWASDB ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. 24770881 2014
dbSNP: rs157580
rs157580
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0002395
Disease:
Alzheimer's Disease
0.810 GeneticVariation BEFREE Alleles A of CD33 rs3865444 and A of TOMM40 rs157580 were both protective factors for AD onset (OR=0.94, 95% CI: 0.90-0.98, P value=0.003; OR=0.62, 95% CI: 0.57-0.66, P value <0.001). 26795201 2016
dbSNP: rs59007384
rs59007384
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0002395
Disease:
Alzheimer's Disease
T 0.700 GeneticVariation GWASCAT APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. 23419831 2014
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0201657
Disease:
C-reactive protein measurement
G 0.800 GeneticVariation GWASCAT Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? 23844046 2013
dbSNP: rs2075650
rs2075650
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0201657
Disease:
C-reactive protein measurement
G 0.800 GeneticVariation GWASDB Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? 23844046 2013
dbSNP: rs10119
rs10119
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40
CUI: C0201657
Disease:
C-reactive protein measurement
G 0.700 GeneticVariation GWASDB Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? 23844046 2013