rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
21123754
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
21460841
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
21379329
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Identification of novel candidate genes for Alzheimer's disease by autozygosity mapping using genome wide SNP data.
21098978
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASDB
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
20885792
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
20061627
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASCAT
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
20885792
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
20061627
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASDB
Genome-wide analysis of genetic loci associated with Alzheimer disease.
20460622
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASCAT
Genome-wide analysis of genetic loci associated with Alzheimer disease.
20460622
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
19734902
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
19734902
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
19734903
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
19136949
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
19734903
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Age related macular degeneration
0.830
GeneticVariation
BEFREE
In conclusion, our study did not con firm the impact of rs2075650 on advanced AMD risk, indicating that rs2075650 is unlikely a superior marker for APOE/TOMM40 susceptible region with advanced AMD in Han Chinese population.
25304313
2015
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Age related macular degeneration
A
0.830
GeneticVariation
GWASCAT
GWAS meta-analysis confirmed previously reported association of variants at the complement factor H (CFH) (peak P = 1.5×10(-31)) and age-related maculopathy susceptibility 2 (ARMS2) (P = 4.3×10(-24)) loci, and suggested Apolipoprotein E (ApoE) polymorphisms (rs2075650 ; P = 1.1×10(-6)) associated with early AMD .
23326517
2013
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Age related macular degeneration
0.830
GeneticVariation
BEFREE
Our data provide no evidence to support an association of rs2075650 in TOMM40 with nAMD or PCV, suggesting that this gene is unlikely to be a major AMD and PCV susceptibility gene locus in the Chinese population.
24146538
2013
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Age related macular degeneration
A
0.830
GeneticVariation
GWASDB
GWAS meta-analysis confirmed previously reported association of variants at the complement factor H (CFH) (peak P = 1.5×10(-31)) and age-related maculopathy susceptibility 2 (ARMS2) (P = 4.3×10(-24)) loci, and suggested Apolipoprotein E (ApoE) polymorphisms (rs2075650 ; P = 1.1×10(-6)) associated with early AMD .
23326517
2013
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Age related macular degeneration
0.830
GeneticVariation
BEFREE
GWAS meta-analysis confirmed previously reported association of variants at the complement factor H (CFH) (peak P = 1.5×10(-31)) and age-related maculopathy susceptibility 2 (ARMS2) (P = 4.3×10(-24)) loci, and suggested Apolipoprotein E (ApoE) polymorphisms (rs2075650 ; P = 1.1×10(-6)) associated with early AMD .
23326517
2013
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Age related macular degeneration
A
0.830
GeneticVariation
GWASDB
Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.
22694956
2012
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Age related macular degeneration
A
0.830
GeneticVariation
GWASCAT
Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.
22694956
2012
rs157580
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.810
GeneticVariation
GWASCAT
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
30617256
2019
rs157580
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.810
GeneticVariation
GWASCAT
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
30636644
2019
rs157582
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.810
GeneticVariation
BEFREE
Moreover, rs56131196 (P = 1.96 × 10<sup>-454</sup>) and rs157582 (P = 9.70 × 10<sup>-434</sup>) were risk loci for Alzheimer's disease .
31760383
2019