TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Depressive disorder ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7305115
rs7305115
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.020 GeneticVariation BEFREE There was a significant interactive effect of rs7305115 polymorphisms and depression diagnosis on Symbol Digit Modalities Test (SDMT) (P<0.05). 26057341 2015
dbSNP: rs7305115
rs7305115
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.020 GeneticVariation BEFREE We hypothesize that functional polymorphisms (TPH2: rs7305115, 5-HTTLPR and rs25531) within both genes contribute to the risk of depressive disorders after childhood abuse in adult life. 25214390 2014
dbSNP: rs78162420
rs78162420
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.010 GeneticVariation BEFREE Among patients with PD, depression is associated with polymorphism at rs78162420 and rs1545843, both previously linked with depression. 28320136 2017
dbSNP: rs120074175
rs120074175
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.010 GeneticVariation BEFREE Here we use chronic multicircuit neurophysiological recordings to characterize functional interactions across cortical and limbic circuits in mice engineered to express a human loss-of-function depression allele Tph2-(R441H) [Tph2 knockin (Tph2KI)]. 23467366 2013
dbSNP: rs12229394
rs12229394
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease:
Depressive disorder 		0.010 GeneticVariation BEFREE The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men. 19548263 2010