ADRB1, adrenoceptor beta 1, 153

N. diseases: 130; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0005612
Disease:
Birth Weight
C 0.800 GeneticVariation GWASCAT Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. 31043758 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0005612
Disease:
Birth Weight
G 0.800 GeneticVariation GWASCAT New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. 23202124 2013
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0005612
Disease:
Birth Weight
G 0.800 GeneticVariation GWASDB New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. 23202124 2013
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases
0.740 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases
0.740 GeneticVariation BEFREE We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders. 24982877 2014
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases
0.740 GeneticVariation BEFREE The Arg389Gly polymorphism of the ADRB1 gene may be a worthy biological marker to predict the risk of developing cardiovascular diseases given a high-risk atherogenic index. 24371822 2013
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases
0.740 GeneticVariation BEFREE Various studies suggest an association between beta(1)-adrenoceptor gene polymorphisms (Ser49Gly and Arg389Gly) and cardiovascular disorders, including hypertension, cardiomyopathy and congestive heart failure.2. 19673943 2009
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0007222
Disease:
Cardiovascular Diseases
0.740 GeneticVariation BEFREE The human beta(1)-adrenergic receptor, an important therapeutic target in cardiovascular diseases, has 2 common functional polymorphisms (Ser49Gly and Gly389Arg). 16815314 2006
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0005890
Disease:
Body Height
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0871470
Disease:
Systolic Pressure
G 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0871470
Disease:
Systolic Pressure
0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0428883
Disease:
Diastolic blood pressure
C 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C1305849
Disease:
Diastolic blood pressure measurement
C 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0428883
Disease:
Diastolic blood pressure
0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0428883
Disease:
Diastolic blood pressure
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0871470
Disease:
Systolic Pressure
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0871470
Disease:
Systolic Pressure
C 0.700 GeneticVariation GWASCAT Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. 27618447 2016
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure
0.100 GeneticVariation BEFREE The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity. 30978507 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018802
Disease:
Congestive heart failure
0.100 GeneticVariation BEFREE The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure. 30756358 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure
0.100 GeneticVariation BEFREE The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure. 30756358 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018802
Disease:
Congestive heart failure
0.100 GeneticVariation BEFREE The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity. 30978507 2019
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018802
Disease:
Congestive heart failure
0.100 GeneticVariation BEFREE Bucindolol is a non-selective beta-blocker with mild vasodilator activity previously found to have accentuated antiarrhythmic effects and increased efficacy for preventing heart failure events in patients homozygous for the major allele of the ADRB1 Arg389Gly polymorphism (ADRB1 Arg389Arg genotype). 29754666 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure
0.100 GeneticVariation BEFREE Bucindolol is a non-selective beta-blocker with mild vasodilator activity previously found to have accentuated antiarrhythmic effects and increased efficacy for preventing heart failure events in patients homozygous for the major allele of the ADRB1 Arg389Gly polymorphism (ADRB1 Arg389Arg genotype). 29754666 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018802
Disease:
Congestive heart failure
0.100 GeneticVariation BEFREE We used uniform methodology to investigate BB dose-ADRB1 Arg389Gly polymorphism interaction with major clinical end points in BEST/bucindolol and HF-ACTION/other BB databases. 30354340 2018
dbSNP: rs1801253
rs1801253
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
CUI: C0018801
Disease:
Heart failure
0.100 GeneticVariation BEFREE We used uniform methodology to investigate BB dose-ADRB1 Arg389Gly polymorphism interaction with major clinical end points in BEST/bucindolol and HF-ACTION/other BB databases. 30354340 2018