DRD2, dopamine receptor D2, 1813

N. diseases: 437; N. variants: 42
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1079596
rs1079596
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0202236
Disease:
Triglycerides measurement
T 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs11214607
rs11214607
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0525045
Disease:
Mood Disorders
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. 29942085 2018
dbSNP: rs11214607
rs11214607
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C1269683
Disease:
Major Depressive Disorder
0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. 29942085 2018
dbSNP: rs7131440
rs7131440
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0596887
Disease:
mathematical ability
T 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs7131627
rs7131627
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0596887
Disease:
mathematical ability
A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs17601612
rs17601612
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0424574
Disease:
Duration of sleep
C 0.700 GeneticVariation GWASCAT Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. 27992416 2017
dbSNP: rs2734839
rs2734839
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0582591
Disease:
Processing speed
T 0.700 GeneticVariation GWASCAT GWAS for executive function and processing speed suggests involvement of the CADM2 gene. 25869804 2016
dbSNP: rs11214606
rs11214606
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0025265
Disease:
Memory, Short-Term
0.700 GeneticVariation GWASCAT Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. 21107309 2011
dbSNP: rs1801028
rs1801028
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE A total of 7 gene polymorphisms from DRD2 (rs1800497, rs1079597, rs1800498, rs1801028) and 5-HT2 A (rs6313, rs6311, rs6305) were genotyped for their association with schizophrenia. 30389402 2019
dbSNP: rs1801028
rs1801028
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Ser311Cys (rs1801028) mutation was absent in the North Indian patients suffering from schizophrenia. 28692863 2017
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE This work has implications for a number of psychiatric conditions in which dopamine signaling and variation in C957T status have been implicated, including schizophrenia and substance use disorders. 28398340 2017
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Remarkably, alleles of <i>COMT</i> rs165774 (G), <i>DRD2</i> rs6277 (T), and <i>DRD3</i> rs6280 (C) were associated with raised predisposition to schizophrenia (all <i>P</i><0.001). 29255361 2017
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE The DRD2 C957T is also associated with schizophrenia, with the C allele being the risk allele. 29945153 2017
dbSNP: rs1801028
rs1801028
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis. 27829443 2016
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Our meta-analysis suggests an association of the DRD2 gene and the risk for schizophrenia, given that TaqI and C957T polymorphisms presented a protective effect against schizophrenia, and in the sub-analyses the C957T variant increased the risk for this disorder in the Chinese population. 27829443 2016
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE In a cross-sectional study, we examined 2 dopamine D2 receptor (DRD2) single-nucleotide polymorphisms (SNPs) previously associated with schizophrenia (C939 T, rs6275 and C957 T, rs6277) along with fasting blood glucose and body mass index (BMI) in 207 antipsychotic-treated patients with schizophrenia. 27254804 2016
dbSNP: rs1801028
rs1801028
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE The rs1801028 locus was associated with schizophrenia, with a pooled OR of 1.221 (95% CI = 1.037-1.438, P = 0.016). 25504812 2015
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Our study suggested that C957T of DRD2 gene polymorphism is likely to be a risk factor for schizophrenia, especially in Caucasian. 25240594 2014
dbSNP: rs1801028
rs1801028
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE The relationships between DRD2 and clinical phenotypes are of particular interest because DRD2 has been shown to associate with treatment response and prefrontal dopamine transmission.Glatt et al. reported significant associations between schizophrenia and DRD2 variants (two single-nucleotide polymorphisms (SNPs) rs1079727 and rs2283265, and two haplotypes, block 3 (rs1079727(A)-rs2440390(C)-rs2283265(G)) and block 4 (rs1801028(G)-rs1110977(A)-rs1124492(C)-rs2734841 (T))) in 2408 Han Chinese individuals in Taiwan. 23364393 2013
dbSNP: rs1801028
rs1801028
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE In conclusion, the G allele of DRD2 Ser311Cys polymorphism involves a potential risk factor for schizophrenia in Asian populations, especially in the Japanese population. 22370928 2012
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE We have previously identified a genetic variant in DRD2, rs6277 to be strongly implicated in schizophrenia susceptibility. 21861710 2012
dbSNP: rs1801028
rs1801028
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: Ser311Cys polymorphisms of the dopamine D2-receptor gene and schizophrenia. 20716857 2010
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Our data indicated a nominally significant association of rs6277 with SZ, with T-allele being the risk allele (OR=1.58, 95%CI=1.03-2.43, P=0.034). 19913597 2010
dbSNP: rs1801028
rs1801028
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE We did not find a significant effect of rs1801028, but we did find significant evidence for association of schizophrenia with two multi-marker haplotypes spanning blocks of strong linkage disequilibrium (LD) and nine individual SNPs (Ps<0.05). 18332877 2009
dbSNP: rs6277
rs6277
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia
0.100 GeneticVariation BEFREE Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1.76), was considered to be significantly associated with schizophrenia after the replication study using independent sample sets. 19158809 2009