ALK, ALK receptor tyrosine kinase, 238

N. diseases: 519; N. variants: 41
Disease: Inflammatory Myofibroblastic Tumor ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs281864719
rs281864719
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0334121
Disease:
Inflammatory Myofibroblastic Tumor 		0.010 GeneticVariation BEFREE Here we report the identification of a secondary mutation in ALK, F1174L, as one cause of crizotinib resistance in a patient with an inflammatory myofibroblastic tumor (IMT) harboring a RANBP2-ALK translocation who progressed while on crizotinib therapy. 21030459 2010
dbSNP: rs863225281
rs863225281
Entrez Id: 238
Gene Symbol: ALK
ALK
CUI: C0334121
Disease:
Inflammatory Myofibroblastic Tumor 		0.010 GeneticVariation BEFREE Here we report the identification of a secondary mutation in ALK, F1174L, as one cause of crizotinib resistance in a patient with an inflammatory myofibroblastic tumor (IMT) harboring a RANBP2-ALK translocation who progressed while on crizotinib therapy. 21030459 2010