|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
The results showed that rs9277535 allele frequency is associated with HBV infection in the Turkish subjects examined (P=0.048).
|
28119119 |
2017 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
No significant correlation was shown in HLA-DP rs3077 and rs9277535 with HBV infection or liver function recovery (P < .05).Our study concluded that HLA-DP (rs3077 and rs9277535) and HLA-DQ (rs7453920) were not significantly associated with HBV recurrence or HBV susceptibility, but HLA-DQ rs7453920 was related to prognosis of liver transplant recipients.
|
28640108 |
2017 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of logistic regression analyses showed that the HLA-DPB1 rs9277535 variants were associated with a reduced risk of persistent HBV infection (odds ratio [OR] 0.70, 95% confidence interval [95% CI] 0.52-0.96, P=0.026, additive genetic model; OR 0.60, 95% CI 0.38-0.96, P=0.033, dominant genetic model).
|
27051043 |
2016 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported.
|
25041342 |
2015 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
Japanese patients (202) who were hepatitis B e antigen positive at baseline, received LAM as first-line treatment, and consented to HLA-DP genotyping (HLA-DPA1 rs3077 and HLA-DPB1 rs9277535) were categorized into two cohorts, viz., a cohort who achieved virological response without rescue therapy (cohort 1) and those who did so with rescue therapy (cohort 2).
|
25103089 |
2015 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified 76 SNPs and 5 LD blocks in HLA-DP/DQ clusters that are significantly associated with HBV infection, with the smallest P value being 3.88 × 10(-18) for rs9277535 in HLA-DPB1.
|
26197724 |
2015 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
We found that rs3077 and rs9277535 in HLA-DP significantly decreased HBV infection risks and increased HBV clearance possibility in a dose-dependent manner.
|
26462556 |
2015 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
The combination of rs9277535 in HLA and rs16944 in IL1B was the best model to predict chronic HBV infection (testing accuracy = 0.6040, P = 0.0010, cross-validation consistency = 10/10).
|
25469587 |
2015 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
The results showed that rs2856718, rs3077, rs9277535 and rs9275572 were associated with HBV infection (p = 0.0003, OR = 1.351, CI = 1.147-1.591; p = 0.041, OR = 1.20, CI = 1.007-1.43; p = 0.045, OR = 1.198, CI = 1.004-1.43 and p = 0.0018, OR = 0.776, CI = 0.662-0.910, respectively).
|
24465366 |
2014 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
G |
0.900 |
GeneticVariation |
GWASDB |
We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection.
|
24940741 |
2014 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection.
|
24940741 |
2014 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
A phylogenetic analysis revealed that the isolated HBV was genotype H. In this patient, the elevated peak level of HBV-DNA and the risk alleles at human genome single nucleotide polymorphisms s3077 and rs9277535 in the human leukocyte antigen-DP locus were considered to be risk factors for chronic infection.
|
24659896 |
2014 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection.
|
23326374 |
2013 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results demonstrated that the rs3077 and rs9277535 HLA-DP polymorphisms reduced HBV infection and increased the likelihood of spontaneous viral clearance in some Asian populations.
|
23601003 |
2013 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
The genome-wide association study (GWAS) variant (rs9277535; 550A/G) in the 3'UTR of the HLA-DPB1 gene that associated most significantly with chronic hepatitis B and outcomes to HBV infection in Asians had a marginal effect on HBV recovery in our European- and African-American samples (odds ratio [OR] = 0.39, P = 0.01, combined ethnic groups).
|
22496224 |
2012 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
G |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4-1.9; p = 1).
|
22448225 |
2012 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of meta-analysis pooling all eligible studies also showed that rs3077-A and rs9277535-A alleles were associated with an increased clearance rate to HBV infection (rs3077: OR=0.57, 95% CI=0.44-0.75; rs9277535: OR=0.56, 95% CI=0.47-0.63).
|
22543033 |
2012 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B virus (HBV) infection in Japanese populations.
|
22105689 |
2012 |
|
rs9277535
|
HLA-DPB1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results confirmed that two SNPs (rs2395309 and rs9277535) in the HLA-DP loci were strongly associated with HBV infection in southern and northern Han Chinese populations, but not with HBV progression.
|
21904616 |
2011 |