HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1045411
rs1045411
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1305855
Disease:
Body mass index
T 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs1045411
rs1045411
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0205682
Disease:
Waist-Hip Ratio
T 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs12861824
rs12861824
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0200638
Disease:
Eosinophil count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2249825
rs2249825
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1305855
Disease:
Body mass index
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs9579583
rs9579583
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0014772
Disease:
Red Blood Cell Count measurement
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs9579583
rs9579583
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1360485
rs1360485
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0205682
Disease:
Waist-Hip Ratio
T 0.700 GeneticVariation GWASCAT Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors. 30575882 2018
dbSNP: rs7330209
rs7330209
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin
C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs9508759
rs9508759
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0524587
Disease:
Mean Corpuscular Volume (result)
A 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs9579586
rs9579586
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0524587
Disease:
Mean Corpuscular Volume (result)
C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs2249825
rs2249825
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0036690
Disease:
Septicemia
0.020 GeneticVariation BEFREE The HMGB1 gene rs2249825 and rs1045411 site SNPs are associated with susceptibility and outcomes of Chinese Han patients with sepsis. 30423384 2019
dbSNP: rs2249825
rs2249825
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0243026
Disease:
Sepsis
0.020 GeneticVariation BEFREE The HMGB1 gene rs2249825 and rs1045411 site SNPs are associated with susceptibility and outcomes of Chinese Han patients with sepsis. 30423384 2019
dbSNP: rs1360485
rs1360485
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0684249
Disease:
Carcinoma of lung
0.020 GeneticVariation BEFREE For rs1360485 polymorphism, AG and GG genotypes could decrease the risk of lung adenocarcinoma and female lung cancer by 0.771-fold and 0.789-fold. 29617336 2018
dbSNP: rs1360485
rs1360485
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.020 GeneticVariation BEFREE For rs1360485 polymorphism, AG and GG genotypes could decrease the risk of lung adenocarcinoma and female lung cancer by 0.771-fold and 0.789-fold. 29617336 2018
dbSNP: rs1360485
rs1360485
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.020 GeneticVariation BEFREE For rs1360485 polymorphism, AG and GG genotypes could decrease the risk of lung adenocarcinoma and female lung cancer by 0.771-fold and 0.789-fold. 29617336 2018
dbSNP: rs1412125
rs1412125
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0684249
Disease:
Carcinoma of lung
0.020 GeneticVariation BEFREE Results indicated that rs1412125 polymorphism was associated with lung cancer risk, especially with the risk of lung adenocarcinoma and small cell lung cancer. 29617336 2018
dbSNP: rs1412125
rs1412125
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.020 GeneticVariation BEFREE Results indicated that rs1412125 polymorphism was associated with lung cancer risk, especially with the risk of lung adenocarcinoma and small cell lung cancer. 29617336 2018
dbSNP: rs1412125
rs1412125
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.020 GeneticVariation BEFREE Results indicated that rs1412125 polymorphism was associated with lung cancer risk, especially with the risk of lung adenocarcinoma and small cell lung cancer. 29617336 2018
dbSNP: rs1045411
rs1045411
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C2239176
Disease:
Liver carcinoma
0.020 GeneticVariation BEFREE Haplotype analysis showed that the T-C-T haplotype (rs1045411-rs2249825-rs1415125) in HMGB1 gene was associated with a 2.47-fold (95% CI: 1.41-4.34; P = 0.002) increased risk of hepatocellular carcinoma compared with the commonest C-C-T haplotype after adjustment. 28187002 2017
dbSNP: rs1360485
rs1360485
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.020 GeneticVariation BEFREE We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). 29104475 2017
dbSNP: rs1360485
rs1360485
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.020 GeneticVariation BEFREE We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). 29104475 2017
dbSNP: rs1360485
rs1360485
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0684249
Disease:
Carcinoma of lung
0.020 GeneticVariation BEFREE We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). 29104475 2017
dbSNP: rs2249825
rs2249825
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0684249
Disease:
Carcinoma of lung
0.020 GeneticVariation BEFREE We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). 29104475 2017
dbSNP: rs2249825
rs2249825
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.020 GeneticVariation BEFREE We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). 29104475 2017
dbSNP: rs2249825
rs2249825
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.020 GeneticVariation BEFREE We found that the CT or CC+CT heterozygotes of the <i>HMGB1</i> rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three <i>HMGB1</i> SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold). 29104475 2017