rs1000113
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
0.840
GeneticVariation
BEFREE
IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset CD as risk loci and defense loci, respectively.
25944217
2015
rs1000113
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
0.840
GeneticVariation
BEFREE
Significant associations with Crohn's disease were noted with the T allele of rs1000113 (OR 1.46, 95% CI 1.12-1.90), T allele of rs9637876 (OR 1.25, 95% CI 1.005-1.561) and C allele of rs 13361189 (OR 1.33, 95% CI 1.07-1.669).
25191865
2014
rs1000113
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
0.840
GeneticVariation
BEFREE
Our analysis revealed an association of the IRGM SNPs rs13371189 (p = 0.02, OR 1.31 [95% CI 1.05-1.65]), rs10065172 = p.Leu105Leu (p = 0.016, OR 1.33 [95% CI 1.06-1.66]) and rs1000113 (p = 0.047, OR 1.27 [95% CI 1.01-1.61]) with CD susceptibility.
23365659
2013
rs1000113
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
0.840
GeneticVariation
BEFREE
We replicated the previously reported associations between CD and rs1000113 and rs4958847, confirming that IRGM is a susceptibility locus only for CD , either adult- or early-onset in the Italian population; furthermore, we have also shown its influence on specific clinical features (fistulizing disease).
19098858
2009
rs1000113
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
T
0.840
GeneticVariation
GWASDB
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
17554300
2007
rs1000113
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
T
0.840
GeneticVariation
GWASCAT
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
17554300
2007
rs11747270
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
0.820
GeneticVariation
BEFREE
IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD .
31654602
2020
rs11747270
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
0.820
GeneticVariation
BEFREE
Two SNPs--rs11747270 and rs180802994--did not exhibit Hardy-Weinberg equilibrium but were associated with both Crohn's disease and ulcerative colitis in this population.
25191865
2014
rs11747270
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
G
0.820
GeneticVariation
GWASCAT
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
18587394
2008
rs11747270
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
G
0.820
GeneticVariation
GWASDB
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
18587394
2008
rs11741861
ZNF300;IRGM
Inflammatory Bowel Diseases
0.800
GeneticVariation
GWASCAT
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
28067908
2017
rs11741861
ZNF300;IRGM
Inflammatory Bowel Diseases
G
0.800
GeneticVariation
GWASDB
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
23128233
2012
rs11741861
ZNF300;IRGM
Inflammatory Bowel Diseases
G
0.800
GeneticVariation
GWASCAT
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
23128233
2012
rs7714584
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
G
0.800
GeneticVariation
GWASDB
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
21102463
2010
rs7714584
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
G
0.800
GeneticVariation
GWASCAT
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
21102463
2010
rs11741861
ZNF300;IRGM
Crohn Disease
0.700
GeneticVariation
GWASCAT
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
28067908
2017
rs11749391
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Psoriasis
0.700
GeneticVariation
GWASCAT
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
26974007
2016
rs11749391
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Cholangitis, Sclerosing
0.700
GeneticVariation
GWASCAT
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
26974007
2016
rs11749391
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Ulcerative Colitis
0.700
GeneticVariation
GWASCAT
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
26974007
2016
rs11749391
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Ankylosing spondylitis
0.700
GeneticVariation
GWASCAT
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
26974007
2016
rs11749391
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Crohn Disease
0.700
GeneticVariation
GWASCAT
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
26974007
2016
rs11741861
ZNF300;IRGM
Crohn Disease
G
0.700
GeneticVariation
GWASCAT
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
26192919
2015
rs11741861
ZNF300;IRGM
Ulcerative Colitis
G
0.700
GeneticVariation
GWASCAT
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
26192919
2015
rs11747270
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Asthma
0.700
GeneticVariation
GWASDB
Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
21150878
2011
rs11747270
×
Entrez Id:
345611
Gene Symbol:
IRGM
IRGM
Multiple Sclerosis
0.700
GeneticVariation
GWASDB
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
22190364
2011