IGF1, insulin like growth factor 1, 3479

N. diseases: 1206; N. variants: 36
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6214
rs6214
Entrez Id: 3479;101101692;105369942
Gene Symbol: IGF1;HELLPAR;LINC02456
IGF1;HELLPAR;LINC02456
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
dbSNP: rs9308315
rs9308315
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0042834
Disease:
Vital capacity 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs972936
rs972936
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0016529
Disease:
Forced expiratory volume function 		T 0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
dbSNP: rs972936
rs972936
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C1518922
Disease:
peak expiratory flow (procedure) 		T 0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
dbSNP: rs972936
rs972936
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0042834
Disease:
Vital capacity 		T 0.700 GeneticVariation GWASCAT New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. 30804560 2019
dbSNP: rs5742643
rs5742643
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 30224653 2018
dbSNP: rs587779350
rs587779350
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C1837475
Disease:
Insulin-Like Growth Factor I Deficiency 		A 0.700 CausalMutation CLINVAR Genomic analysis of primordial dwarfism reveals novel disease genes. 24389050 2014
dbSNP: rs5742617
rs5742617
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs5742626
rs5742626
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs5742626
rs5742626
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0428472
Disease:
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs5742626
rs5742626
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs5742663
rs5742663
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs5742683
rs5742683
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs7300373
rs7300373
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs5742692
rs5742692
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0489786
Disease:
Height 		G 0.700 GeneticVariation GWASDB A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. 20189936 2010
dbSNP: rs5742692
rs5742692
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C0005890
Disease:
Body Height 		G 0.700 GeneticVariation GWASCAT A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. 20189936 2010
dbSNP: rs121912430
rs121912430
Entrez Id: 3479;105369942
Gene Symbol: IGF1;LINC02456
IGF1;LINC02456
CUI: C1837475
Disease:
Insulin-Like Growth Factor I Deficiency 		T 0.700 CausalMutation CLINVAR
dbSNP: rs745805222
rs745805222
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation BEFREE Overall results suggest changes in neuromodulator levels are subtle in SOD1-G93A ALS mixed cell cultures. 30618638 2018
dbSNP: rs745805222
rs745805222
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation BEFREE Therefore, the aim of this study was to investigate the effect of intravenous delivery of human IGF1 by self-complementary adeno-associated virus (scAAV) vectors in 90-day-old SOD1-G93A ALS mice. 29499331 2018
dbSNP: rs745805222
rs745805222
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation BEFREE Intraspinal administration of human spinal cord-derived neural progenitor cells in the G93A-SOD1 mouse model of ALS delays symptom progression, prolongs survival and increases expression of endogenous neurotrophic factors. 25641599 2017
dbSNP: rs745805222
rs745805222
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation BEFREE Finally, AAV9::IGF-2 delivery to muscles of SOD1(G93A) ALS mice extended life-span by 10%, while preserving motor neurons and inducing motor axon regeneration. 27180807 2016
dbSNP: rs745805222
rs745805222
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation BEFREE Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (i.c.v.) with the anti-mitotic drug cytosine arabinoside (Ara-C).I.c.v. delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS. 22523565 2012
dbSNP: rs745805222
rs745805222
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation BEFREE We report that symptomatic male hSOD1(G93A) transgenic mice exhibit a deficiency in GH secretion similar to that seen in human ALS. 22621959 2012
dbSNP: rs745805222
rs745805222
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation BEFREE Therefore, we investigate the influence of the soluble factors released by hADSCs on the GLT1 in primary astrocytes cultured from SOD1(G93A) mice, a widely studied mutant human SOD1 transgenic model of ALS. 20152807 2010
dbSNP: rs745805222
rs745805222
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.100 GeneticVariation BEFREE Although viral delivery of IGF-I has shown therapeutic efficacy in the SOD1(G93A) mouse model of ALS, clinical trials of IGF-I in ALS patients have led to conflicting results. 19038252 2009