IL1B, interleukin 1 beta, 3553

N. diseases: 1801; N. variants: 22
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1143623
rs1143623
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C3815172
Disease:
Interleukin 1 Beta Measurement
0.700 GeneticVariation GWASCAT GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation. 30206230 2018
dbSNP: rs1143627
rs1143627
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C3815172
Disease:
Interleukin 1 Beta Measurement
0.700 GeneticVariation GWASCAT GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation. 30206230 2018
dbSNP: rs1143634
rs1143634
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C3815172
Disease:
Interleukin 1 Beta Measurement
0.700 GeneticVariation GWASCAT GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation. 30206230 2018
dbSNP: rs16944
rs16944
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C3815172
Disease:
Interleukin 1 Beta Measurement
0.700 GeneticVariation GWASCAT GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation. 30206230 2018
dbSNP: rs1143633
rs1143633
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1527304
Disease:
Allergic Reaction
C 0.700 GeneticVariation GWASCAT Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. 29083406 2017
dbSNP: rs1143627
rs1143627
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C4016230
Disease:
GASTRIC CANCER SUSCEPTIBILITY AFTER H. PYLORI INFECTION
A 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. 28357805 2018
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE The PRR NLRC4, caspase 1 and IL1β were significantly elevated in denervated muscle of SOD1<sup>(G93A)</sup> mice and sALS patients. 29575052 2018
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice. 27880990 2018
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE Inflammasome activation was recently shown in the spinal cord of human sporadic ALS patients and in the SOD1(G93A) mouse model for ALS. 27957680 2017
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE In this study, we investigated the expression, activation and co-localization of the NLRP3 inflammasome in the spinal cord of male SOD1(G93A) mice carrying a mutant human superoxide dismutase 1 (SOD1) variant and regarded as an animal model for ALS as well as in post-mortem tissue of ALS patients. 26200799 2015
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE Here, we show the therapeutic benefits of a modified peptide agonist stearyl-norleucine-VIP (SNV) in a transgenic rat model of amyotrophic lateral sclerosis (mutated superoxide dismutase 1, hSOD1(G93A)). 25311268 2015
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS). 24820540 2014
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (i.c.v.) with the anti-mitotic drug cytosine arabinoside (Ara-C).I.c.v. delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS. 22523565 2012
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE We show here that the expression of caspase-11 is upregulated in the spinal cord of superoxide dismutase 1 (SOD1) G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis (ALS), before the onset of motor dysfunction and remains at the high levels throughout the course of disease. 12843244 2003
dbSNP: rs1445888481
rs1445888481
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.100 GeneticVariation BEFREE Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. 12124437 2002
dbSNP: rs16944
rs16944
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0036341
Disease:
Schizophrenia
0.060 GeneticVariation BEFREE We have found a trend toward an association of rs1143627, rs16944, rs1143623 in IL1B gene with the risk of schizophrenia. 28083609 2016
dbSNP: rs16944
rs16944
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0036341
Disease:
Schizophrenia
0.060 GeneticVariation BEFREE Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia. 24155145 2014
dbSNP: rs16944
rs16944
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0036341
Disease:
Schizophrenia
0.060 GeneticVariation BEFREE The present study examined the effects of a functional polymorphism at IL1B gene promoter (-511C/T; rs16944) on brain correlates of working memory performance in schizophrenia. 22763186 2012
dbSNP: rs16944
rs16944
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0036341
Disease:
Schizophrenia
0.060 GeneticVariation BEFREE A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032). 21843369 2011
dbSNP: rs16944
rs16944
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0036341
Disease:
Schizophrenia
0.060 GeneticVariation BEFREE The combined allele-wise odds ratio (OR) for schizophrenia of the rs16944 (IL1B gene; T-511C) polymorphism was 0.86 (95% CI: 0.77to 0.96).When applying stratified analysis to this polymorphism, the pooled allele-wise OR was 0.88 (95% CI, 0.79 to 0.97) in 10 population-based studies and 0.85 (95% CI: 0.73 to 0.99) in Caucasian samples. 20347268 2010
dbSNP: rs16944
rs16944
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0036341
Disease:
Schizophrenia
0.060 GeneticVariation BEFREE However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1beta -511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n=819 cases, 1292 controls; p=0.0013, OR=1.24, 95% CI 1.09, 1.41). 16905295 2006
dbSNP: rs1143634
rs1143634
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0266929
Disease:
Chronic Periodontitis
0.040 GeneticVariation BEFREE We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis. 30939298 2019
dbSNP: rs1143634
rs1143634
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0266929
Disease:
Chronic Periodontitis
0.040 GeneticVariation BEFREE This meta-analysis in 9376 participants with 54 case/control studies revealed the rs1143634 polymorphism was associated with elevated risk of chronic periodontitis in overall analysis as well as Caucasian and Asian ethnicities and Mixed population. 29783069 2018
dbSNP: rs1143634
rs1143634
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0266929
Disease:
Chronic Periodontitis
0.040 GeneticVariation BEFREE In conclusion, literature review suggests that for IL1B SNP rs1143634, EARR and CP have an opposite genetic profile. 30142580 2018