CXCL8, C-X-C motif chemokine ligand 8, 3576

N. diseases: 1254; N. variants: 10
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2227544
rs2227544
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1445957
Disease:
Serum total cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.050 GeneticVariation BEFREE The major findings of this meta-analysis suggested that IL-8 rs4073 polymorphism is significantly associated with risk of prostate cancer. 31718853 2019
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0600139
Disease:
Prostate carcinoma
0.050 GeneticVariation BEFREE The major findings of this meta-analysis suggested that IL-8 rs4073 polymorphism is significantly associated with risk of prostate cancer. 31718853 2019
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.050 GeneticVariation BEFREE The frequency of the A allele of the rs4073 was significantly lower in PCa group compared with BPH group (OR (95% CI) = 0.62 (0.46-0.84), adjusted P value = 0.006). 30641210 2019
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0600139
Disease:
Prostate carcinoma
0.050 GeneticVariation BEFREE The frequency of the A allele of the rs4073 was significantly lower in PCa group compared with BPH group (OR (95% CI) = 0.62 (0.46-0.84), adjusted P value = 0.006). 30641210 2019
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0600139
Disease:
Prostate carcinoma
0.050 GeneticVariation BEFREE Minor alleles of rs2243250 (T) in IL4 (OR = 1.46, 95% CI 1.03-2.08, P-trend = 0.03), rs1800896 (G) in IL10 (OR = 0.77, 95% CI 0.61-0.96, P-trend = 0.02), rs2430561 (A) in IFNG (OR = 1.33, 95% CI 1.02-1.74; P-trend = 0.04), rs3747531 (C) in MSR1 (OR = 0.55, 95% CI 0.32-0.95; P-trend = 0.03), and possibly rs4073 (A) in IL8 (OR = 0.81, 95% CI 0.64-1.01, P-trend = 0.06) were associated with higher- (Gleason 7-10; N = 222), but not lower- (Gleason 2-6; N = 380) grade prostate cancer. 28317149 2017
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.050 GeneticVariation BEFREE Minor alleles of rs2243250 (T) in IL4 (OR = 1.46, 95% CI 1.03-2.08, P-trend = 0.03), rs1800896 (G) in IL10 (OR = 0.77, 95% CI 0.61-0.96, P-trend = 0.02), rs2430561 (A) in IFNG (OR = 1.33, 95% CI 1.02-1.74; P-trend = 0.04), rs3747531 (C) in MSR1 (OR = 0.55, 95% CI 0.32-0.95; P-trend = 0.03), and possibly rs4073 (A) in IL8 (OR = 0.81, 95% CI 0.64-1.01, P-trend = 0.06) were associated with higher- (Gleason 7-10; N = 222), but not lower- (Gleason 2-6; N = 380) grade prostate cancer. 28317149 2017
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.050 GeneticVariation BEFREE The purpose of this study was to evaluate the relationship between single-nucleo­tide polymorphism (SNP) rs2228001 in xeroderma pigmentosum group C (XPC), SNP rs4073 in interleukin 8 (IL8), and SNP rs2279744 in mouse double minute 2 (MDM2) homolog gene with PCa susceptibility. 26135929 2015
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0600139
Disease:
Prostate carcinoma
0.050 GeneticVariation BEFREE The purpose of this study was to evaluate the relationship between single-nucleo­tide polymorphism (SNP) rs2228001 in xeroderma pigmentosum group C (XPC), SNP rs4073 in interleukin 8 (IL8), and SNP rs2279744 in mouse double minute 2 (MDM2) homolog gene with PCa susceptibility. 26135929 2015
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.050 GeneticVariation BEFREE After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk. 20431935 2010
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0600139
Disease:
Prostate carcinoma
0.050 GeneticVariation BEFREE After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk. 20431935 2010
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0041296
Disease:
Tuberculosis
0.040 GeneticVariation BEFREE IL-2 rs2069762 (recessive comparison), IL-4 rs2243250 (recessive and allele comparisons), IL-6 rs1800795 (dominant, recessive and allele comparisons), IL-8 rs4073 (dominant, recessive and allele comparisons), IL-10 rs1800871 (dominant, recessive and allele comparisons) and IL-10 rs1800896 (recessive comparison) polymorphisms were all significantly associated with TB in the total population. 31669382 2020
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1956346
Disease:
Coronary Artery Disease
0.040 GeneticVariation BEFREE Interleukin-8 Gene -251 A/T (rs4073) Polymorphism and Coronary Artery Disease Risk: A Meta-Analysis. 30826813 2019
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0041296
Disease:
Tuberculosis
0.040 GeneticVariation BEFREE Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB. 31560754 2019
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1956346
Disease:
Coronary Artery Disease
0.040 GeneticVariation BEFREE Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population. 30073578 2019
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE Further subgroup analyses based on ethnicities of participants revealed that the IL-4 rs2</span>243250, IL-6 rs1800796 and IL-8 rs4073 polymorphisms were significantly associated with the risk of GC in Asians. 30071135 2018
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE Significant associations with the risk of gastric cancer were only detected for the IL-8 rs4073 polymorphism in overall analyses. 30195978 2018
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0699791
Disease:
Stomach Carcinoma
0.040 GeneticVariation BEFREE Significant associations with the risk of gastric cancer were only detected for the IL-8 rs4073 polymorphism in overall analyses. 30195978 2018
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0699791
Disease:
Stomach Carcinoma
0.040 GeneticVariation BEFREE Further subgroup analyses based on ethnicities of participants revealed that the IL-4 rs2</span>243250, IL-6 rs1800796 and IL-8 rs4073 polymorphisms were significantly associated with the risk of GC in Asians. 30071135 2018
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1956346
Disease:
Coronary Artery Disease
0.040 GeneticVariation BEFREE We conducted an investigation to assess the relationship between the IL-8 -251A/T (rs4073) sequence variant and CAD in a Chinese population. 28218776 2017
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0041296
Disease:
Tuberculosis
0.040 GeneticVariation BEFREE Secretion of IL8 by peripheral blood cells was greatly stimulated upon exposure to Mycobacterium tuberculosis whole cell extract, but such enhanced secretion was not associated with the IL8 rs4073 alleles. 27003175 2016
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1956346
Disease:
Coronary Artery Disease
0.040 GeneticVariation BEFREE We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD). 26505399 2015
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.040 GeneticVariation BEFREE The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC). 26088449 2015
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0699791
Disease:
Stomach Carcinoma
0.040 GeneticVariation BEFREE The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC). 26088449 2015
dbSNP: rs4073
rs4073
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0041296
Disease:
Tuberculosis
0.040 GeneticVariation BEFREE A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG haplotype (PR 1.298, 95%CI 1.059-1.589) and with the IL-10 AT/CC diplotype (PR 1.181, 95% CI 1.024-1.362), and the presence of the IL-8 rs4073 T allele was associated with protection against TB (PR 0.482, 95%CI 0.273-0.851). 25199010 2014