CXCR1, C-X-C motif chemokine receptor 1, 3577

N. diseases: 167; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2234671
rs2234671
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0033845
Disease:
Pseudotumor Cerebri
0.700 GeneticVariation GWASCAT Genetic Survey of Adult-Onset Idiopathic Intracranial Hypertension. 29608535 2019
dbSNP: rs2234671
rs2234671
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0042029
Disease:
Urinary tract infection
0.020 GeneticVariation BEFREE CXCR1 rs2234671 polymorphism might be associated with an increased risk of UTI in children. 29577511 2019
dbSNP: rs2234671
rs2234671
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0042029
Disease:
Urinary tract infection
0.020 GeneticVariation BEFREE We did not find any association of CXCR1 rs2234671 polymorphism with UTI by comparing with any group. 29066305 2018
dbSNP: rs2234671
rs2234671
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0520575
Disease:
Acute pyelonephritis
0.010 GeneticVariation BEFREE However, subgroup analysis showed that rs2234671 was associated with an increased risk of UTI under allelic comparisons (C vs. G, OR = 1.95, 95% CI = 1.07-3.55), heterozygous model (GC vs. GG, OR = 1.93, 95% CI = 1.06-3.50), and dominant model (GC + CC vs. GG, OR = 1.98, 95% CI = 1.07-3.69) in children, especially in paediatric patients with acute pyelonephritis (allelic, OR = 2.43, 95% CI = 1.28-4.60; heterozygous, OR = 2.40, 95% CI = 1.24-4.62; dominant, OR = 2.48, 95% CI = 1.26-4.88). 29577511 2019
dbSNP: rs2234671
rs2234671
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0019163
Disease:
Hepatitis B
0.010 GeneticVariation BEFREE The CXCR1 polymorphism, rs2234671 was found to be associated with chronic HBV infection and may play a role in disease activity. 23396733 2013
dbSNP: rs2234671
rs2234671
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C1623038
Disease:
Cirrhosis
0.010 GeneticVariation BEFREE The frequency of the risk allele 'C' for the SNP, rs2234671 was found to be insignificant when the patient group was compared to the uninfected control group, however, a significant distribution of the allele 'C' of rs2234671 was observed among active HBV carriers + cirrhosis + cirrhosis - HCC vs. inactive HBV carriers with an OR = 1.631 (95% C.I.1.016-2.616) and p = 0.032. 23396733 2013
dbSNP: rs2234671
rs2234671
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0023890
Disease:
Liver Cirrhosis
0.010 GeneticVariation BEFREE The frequency of the risk allele 'C' for the SNP, rs2234671 was found to be insignificant when the patient group was compared to the uninfected control group, however, a significant distribution of the allele 'C' of rs2234671 was observed among active HBV carriers + cirrhosis + cirrhosis - HCC vs. inactive HBV carriers with an OR = 1.631 (95% C.I.1.016-2.616) and p = 0.032. 23396733 2013
dbSNP: rs2234671
rs2234671
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0023290
Disease:
Leishmaniasis, Visceral
0.010 GeneticVariation BEFREE Family-based analysis using FBAT showed association between VL and SNPs CXCR1_rs2234671 (Z-score = 2.935, P = 0.003) and CXCR1_rs3138060 (Z-score = 2.22, P = 0.026), but not with CXCR2_rs4674259. 22171941 2011
dbSNP: rs2671222
rs2671222
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0011847
Disease:
Diabetes
0.010 GeneticVariation BEFREE The donor GA/AA genotypes of CXCR1 -2668G/A (rs2671222) were associated with increased risk for acute rejection even after adjusting for covariates such as gender, diabetes, preemptive transplantation, immunosuppressive regimen, relationship with the donor, and human leukocyte antigen mismatch (adjusted odds ratio 3.56; 95% confidence interval 1.37-9.27; P=0.009). 21452410 2011
dbSNP: rs2671222
rs2671222
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0011849
Disease:
Diabetes Mellitus
0.010 GeneticVariation BEFREE The donor GA/AA genotypes of CXCR1 -2668G/A (rs2671222) were associated with increased risk for acute rejection even after adjusting for covariates such as gender, diabetes, preemptive transplantation, immunosuppressive regimen, relationship with the donor, and human leukocyte antigen mismatch (adjusted odds ratio 3.56; 95% confidence interval 1.37-9.27; P=0.009). 21452410 2011
dbSNP: rs3138060
rs3138060
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
CUI: C0023290
Disease:
Leishmaniasis, Visceral
0.010 GeneticVariation BEFREE Family-based analysis using FBAT showed association between VL and SNPs CXCR1_rs2234671 (Z-score = 2.935, P = 0.003) and CXCR1_rs3138060 (Z-score = 2.22, P = 0.026), but not with CXCR2_rs4674259. 22171941 2011