IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2070729
rs2070729
Entrez Id: 3659;441108
Gene Symbol: IRF1;IRF1-AS1
IRF1;IRF1-AS1
CUI: C0032181
Disease:
Platelet Count measurement
A 0.800 GeneticVariation GWASCAT New gene functions in megakaryopoiesis and platelet formation. 22139419 2011
dbSNP: rs2070729
rs2070729
Entrez Id: 3659;441108
Gene Symbol: IRF1;IRF1-AS1
IRF1;IRF1-AS1
CUI: C0032181
Disease:
Platelet Count measurement
A 0.800 GeneticVariation GWASDB New gene functions in megakaryopoiesis and platelet formation. 22139419 2011
dbSNP: rs121912469
rs121912469
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0699791
Disease:
Stomach Carcinoma
0.700 GeneticVariation UNIPROT Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update. 23852704 2014
dbSNP: rs6873426
rs6873426
Entrez Id: 3659;441108
Gene Symbol: IRF1;IRF1-AS1
IRF1;IRF1-AS1
CUI: C1561955
Disease:
Fibrinogen, CTCAE
0.700 GeneticVariation GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
dbSNP: rs6873426
rs6873426
Entrez Id: 3659;441108
Gene Symbol: IRF1;IRF1-AS1
IRF1;IRF1-AS1
CUI: C0337428
Disease:
Fibrinogen assay
0.700 GeneticVariation GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
dbSNP: rs6873426
rs6873426
Entrez Id: 3659;441108
Gene Symbol: IRF1;IRF1-AS1
IRF1;IRF1-AS1
CUI: C1325327
Disease:
fibrinogen activity
0.700 GeneticVariation GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
dbSNP: rs121912469
rs121912469
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0699791
Disease:
Stomach Carcinoma
0.700 GeneticVariation UNIPROT Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding. 10395927 1999
dbSNP: rs121912470
rs121912470
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0699791
Disease:
Stomach Carcinoma
0.700 GeneticVariation UNIPROT Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding. 10395927 1999
dbSNP: rs121912469
rs121912469
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0699791
Disease:
Stomach Carcinoma
0.700 GeneticVariation UNIPROT Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. 9679752 1998
dbSNP: rs121912470
rs121912470
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0699791
Disease:
Stomach Carcinoma
0.700 GeneticVariation UNIPROT Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. 9679752 1998
dbSNP: rs121912469
rs121912469
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0038356
Disease:
Stomach Neoplasms
A 0.700 CausalMutation CLINVAR
dbSNP: rs121912470
rs121912470
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
G 0.700 CausalMutation CLINVAR
dbSNP: rs56288038
rs56288038
Entrez Id: 3659;441108
Gene Symbol: IRF1;IRF1-AS1
IRF1;IRF1-AS1
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE our findings have shown that the SNP rs56288038 (C/G) in IRF-1 3'UTR acted as a promotion factor in GC development through enhancing the regulatory role of miR-502-5p in IRF-1 expression. 27866197 2016
dbSNP: rs56288038
rs56288038
Entrez Id: 3659;441108
Gene Symbol: IRF1;IRF1-AS1
IRF1;IRF1-AS1
CUI: C0699791
Disease:
Stomach Carcinoma
0.010 GeneticVariation BEFREE our findings have shown that the SNP rs56288038 (C/G) in IRF-1 3'UTR acted as a promotion factor in GC development through enhancing the regulatory role of miR-502-5p in IRF-1 expression. 27866197 2016
dbSNP: rs56288038
rs56288038
Entrez Id: 3659;441108
Gene Symbol: IRF1;IRF1-AS1
IRF1;IRF1-AS1
CUI: C0027651
Disease:
Neoplasms
0.010 GeneticVariation BEFREE SNP rs56288038 (C/G) in IRF-1 3'UTR was involved in the occurrence of GC by acting as a tumor promoter factor. 27866197 2016
dbSNP: rs2706384
rs2706384
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0024530
Disease:
Malaria
0.010 GeneticVariation BEFREE Both SNP rs2706384 and SNP1805015 have previously been reported to be associated with risk of malaria infection in African populations. 21867552 2011
dbSNP: rs11242115
rs11242115
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0010346
Disease:
Crohn Disease
0.010 GeneticVariation BEFREE Two other SNPs, rs11242115 in IRF1 and rs17166050 in RAD50, lying outside the 250 kb risk haplotype, also showed CD association (P=0.019 and P=0.0080, respectively). 16724073 2006