MDM2, MDM2 proto-oncogene, 4193

N. diseases: 702; N. variants: 30
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C2239176
Disease:
Liver carcinoma
0.050 GeneticVariation BEFREE No publication bias was found for all the meta-analysis as suggested by the Begg funnel plot and Egger tests.These results suggested that variants MDM2 SNP309 and p53 Arg72Pro are susceptibility factors for HCC; however, more studies are warranted to validate the results. 28885338 2017
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C2239176
Disease:
Liver carcinoma
0.050 GeneticVariation BEFREE In addition, our findings further suggest that the combination of MDM2 SNP 309 and TP53 Arg72Pro genotypes confers higher risk to develop HCC. 24376578 2013
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C2239176
Disease:
Liver carcinoma
0.050 GeneticVariation BEFREE Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of hepatocellular carcinoma (HCC) remains inconsistent. 23292895 2013
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C2239176
Disease:
Liver carcinoma
0.050 GeneticVariation BEFREE There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present. 22180176 2012
dbSNP: rs1353702185
rs1353702185
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C2239176
Disease:
Liver carcinoma
0.050 GeneticVariation BEFREE Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patients with chronic HBV infection. 18390844 2008
dbSNP: rs2279744
rs2279744
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C2239176
Disease:
Liver carcinoma
0.030 GeneticVariation BEFREE CG and GG genotypes in rs1042522 and heterozygote and homozygote in rs2279744 were significantly associated with an elevated risk of HCC. 25412941 2014
dbSNP: rs2279744
rs2279744
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C2239176
Disease:
Liver carcinoma
0.030 GeneticVariation BEFREE Thus, the findings from the meta-analysis support that MDM2 rs2279744 polymorphism is significantly associated with increased risk of hep</span>atocellular carcinoma in East Asians. 24061636 2014
dbSNP: rs2279744
rs2279744
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C2239176
Disease:
Liver carcinoma
0.030 GeneticVariation BEFREE Two SNPs (rs1800562 of HFE and rs2279744 of MDM2) were associated with HCC with moderate epidemiological evidence and deserve further study and additional biological and clinical assessment. 21240526 2011