|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
A gain-of-function polymorphism in human neuropeptide Y (<i>NPY</i>) gene (rs16139) associates with metabolic disorders and earlier onset of type 2 diabetes (T2D).
|
28468933 |
2017 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study attempts to investigate the association of NPY exon2 +1128 T/C (Leu7Pro; rs16139), NPY promoter -399 T/C (rs16147) and IL1B -511 C/T (rs16944) polymorphisms with TIID and their correlation with plasma lipid levels, BMI, and IL1B transcript levels.
|
27749914 |
2016 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the associations of inflammatory blood cell activation with vascular parameters in patients with type 2 diabetes to elucidate the possible mechanisms of accelerated atherosclerosis observed in subjects with the Leucine 7 to Proline 7 polymorphism (Leu7Pro) in the neuropeptide Y (NPY).
|
21746772 |
2011 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes.
|
20691708 |
2010 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
The leucine7 to proline7 (Leu7Pro) polymorphism in preproneuropeptide Y (preproNPY) has been associated with accelerated atherosclerosis and type II diabetes, both of which are obesity-related diseases.
|
18043699 |
2009 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.
|
17268419 |
2007 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Since no impact of preproNPY genotype on mean NPY or hormone levels were detected in subjects with type 2 diabetes, the mechanisms for the increased risk for diabetic complications in the subjects with the Leu7Pro polymorphism need to be further explored.
|
17516289 |
2007 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the Leu7Pro polymorphism could be used to predict earlier onset of type 2 diabetes and retinopathy, and increased risk for diabetic nephropathy.
|
16705546 |
2006 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study thus provides the evidence that Leu7Pro polymorphism in the NPY gene is associated with IGT and T2DM in Swedish men, and indicates that the NPY gene variations contribute to development of T2DM.
|
15926114 |
2005 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects.
|
10852461 |
2000 |
|
rs16139
|
NPY;LOC107986777
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation |
BEFREE |
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes.
|
10926322 |
2000 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
This study suggests that NPY rs16147 T and rs16139 C minor alleles are associated with increased risk, whereas the minor allele T of the rs5574 is associated with a reduced risk of obesity.
|
26240981 |
2015 |
|
rs16139
|
NPY;LOC107986777
|
Coronary heart disease
|
|
0.050 |
GeneticVariation |
BEFREE |
Neuropeptide Y Leu7Pro polymorphism associated with the metabolic syndrome and its features in patients with coronary artery disease.
|
22308535 |
2013 |
|
rs16139
|
NPY;LOC107986777
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation |
BEFREE |
Neuropeptide Y Leu7Pro polymorphism associated with the metabolic syndrome and its features in patients with coronary artery disease.
|
22308535 |
2013 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
In this study, we investigated the role of two functional NPY polymorphisms, NPY-Leu7Pro (rs16139) and NPY-399C/T (rs16147) and obesity for the development of asthma as well as atherosclerosis in asthmatic and non-asthmatic subjects.
|
23122776 |
2012 |
|
rs16139
|
NPY;LOC107986777
|
Coronary heart disease
|
|
0.050 |
GeneticVariation |
BEFREE |
High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease.
|
22289186 |
2012 |
|
rs16139
|
NPY;LOC107986777
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation |
BEFREE |
High frequency of Neuropeptide Y Leu7Pro polymorphism in an Iranian population and its association with coronary artery disease.
|
22289186 |
2012 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
Two SNPs (rs17149106 (G>T) and rs16139 (T>C)), with minor allele frequencies of 4%, were associated with elevated risks of obesity (BMI ≥ 30 kg/m(2)) in both cohorts.
|
21937627 |
2011 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
In 6 years follow-up, the polymorphism alone did not change the risk for abnormal glucose regulation, while obesity</span> was associated with a significant 3-fold risk (odds ratio (OR) 2.95; 95% confidence interval (CI) 1.81-4.81, P<0.001) and the Leu7Pro polymorphism-obesity interaction, with a remarkable 12-fold risk (OR 12.33; 95% CI 1.18-128.35, P<0.05).
|
18043699 |
2009 |
|
rs16139
|
NPY;LOC107986777
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation |
BEFREE |
The aim of the present study was to investigate the association of the Leu7Pro polymorphism with coronary atherosclerosis and its consequences.
|
18054939 |
2008 |
|
rs16139
|
NPY;LOC107986777
|
Coronary heart disease
|
|
0.050 |
GeneticVariation |
BEFREE |
The Leu7Pro substitution has been linked to cardiovascular disease, but it is unknown whether the Pro7 allele is associated with increased or decreased risk of coronary heart disease (CHD).
|
18054939 |
2008 |
|
rs16139
|
NPY;LOC107986777
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
The consistent findings among men suggest that the NPY Leu7Pro polymorphism (or another linked marker) might be involved in the development of obesity at younger ages.
|
16568137 |
2006 |
|
rs16139
|
NPY;LOC107986777
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation |
BEFREE |
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients.
|
14747236 |
2004 |
|
rs16139
|
NPY;LOC107986777
|
Coronary heart disease
|
|
0.050 |
GeneticVariation |
BEFREE |
We conclude that the Leu7Pro polymorphism may contribute to the genetic susceptibility to diabetic nephropathy and CHD in type 1 diabetic patients, possibly by influencing glycemic control and triglycerides.
|
14747236 |
2004 |
|
rs16139
|
NPY;LOC107986777
|
Coronary Arteriosclerosis
|
|
0.050 |
GeneticVariation |
BEFREE |
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease.
|
11914038 |
2002 |