NPPB, natriuretic peptide B, 4879

N. diseases: 193; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C2985280
Disease:
Blood Protein Measurement
G 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs3753581
rs3753581
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0001948
Disease:
Alcohol consumption
A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs3753581
rs3753581
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0871470
Disease:
Systolic Pressure
0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs3753581
rs3753581
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0428883
Disease:
Diastolic blood pressure
A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs3753581
rs3753581
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0428883
Disease:
Diastolic blood pressure
0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE The NPPB rs198389 SNP was not associated with T2DM (odds ratio (OR) [95% confidence interval (CI)]=0.73 [0.51-1.04], p=0.08). 25934190 2015
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE Two of the 4 tested variants in NPPA and NPPB (rs632793, rs198389) were associated with increased NT-proBNP concentrations and reduced risk of T2DM. 23288489 2013
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE The association between rs198389 and T2D observed in case-control studies (odds ratio = 0.94 per C allele, 95% CI 0.91-0.97) was similar to that expected (0.96, 0.93-0.98) based on the pooled estimate for the log-NT-pro-BNP level to T2D association derived from a meta-analysis of our study and published data (hazard ratio = 0.82 per SD, 0.74-0.90) and the difference in NT-pro-BNP levels (0.22 SD, 0.15-0.29) per C allele of rs198389. 22039354 2011
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). 19377085 2009
dbSNP: rs198388
rs198388
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease
0.010 GeneticVariation BEFREE Logistics regression analysis showed that <i>BNP</i> rs198389 locus G allele, rs6668352 locus A allele, and rs198388 locus T allele were high risk factors for PH in COPD patients (all <i>P</i><0.001). 30217946 2018
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0003850
Disease:
Arteriosclerosis
0.010 GeneticVariation BEFREE We investigated rs198389, a functional variant in the promoter region of the BNP gene (<i>NPPB</i>), in patients from the Atherosclerosis Risk in Communities Study to investigate associations with N-terminal pro-BNP (NT-proBNP) levels and outcomes. 28341776 2017
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0004153
Disease:
Atherosclerosis
0.010 GeneticVariation BEFREE We investigated rs198389, a functional variant in the promoter region of the BNP gene (<i>NPPB</i>), in patients from the Atherosclerosis Risk in Communities Study to investigate associations with N-terminal pro-BNP (NT-proBNP) levels and outcomes. 28341776 2017
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0020538
Disease:
Hypertensive disease
0.010 GeneticVariation BEFREE The rs198389 G allele in the <i>NPPB</i> promoter is associated with elevated levels of NT-proBNP throughout adult life, reduced blood pressure, hypertension and cardiovascular mortality, and increased lifespan. 28341776 2017
dbSNP: rs550521638
rs550521638
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0268407
Disease:
Senile cardiac amyloidosis
0.010 GeneticVariation BEFREE Along with age, mBMI, and mutation (Val30Met vs. Non-Val30Met), cardiac biomarkers were associated with surrogates of disease severity with BNP/NT-proBNP identified as an independent predictor of survival in ATTR. 28384285 2017
dbSNP: rs550521638
rs550521638
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C2751492
Disease:
AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED
0.010 GeneticVariation BEFREE Along with age, mBMI, and mutation (Val30Met vs. Non-Val30Met), cardiac biomarkers were associated with surrogates of disease severity with BNP/NT-proBNP identified as an independent predictor of survival in ATTR. 28384285 2017
dbSNP: rs198388
rs198388
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0263420
Disease:
Hyperkeratosis lenticularis perstans
0.010 GeneticVariation BEFREE Three NPPA-NPPB polymorphisms (rs632793, rs198388 and rs198389) were associated with reduced risk of LVD in CAD patients with HLP. 25400811 2014
dbSNP: rs198388
rs198388
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0020473
Disease:
Hyperlipidemia
0.010 GeneticVariation BEFREE Subgroup analyses performed by hyperlipidemia (HLP) demonstrated 3 polymorphisms, rs632793 (OR = 0.31, 95% CI 0.1-0.93, P = 0.04), rs198388 (OR = 0.26, 95% CI 0.09-0.79, P = 0.02) and rs198389 (OR = 0.26, 95% CI 0.09-0.80, P = 0.02) were associated with the reduced risk of LVD. 25400811 2014
dbSNP: rs198388
rs198388
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C1956346
Disease:
Coronary Artery Disease
0.010 GeneticVariation BEFREE Three NPPA-NPPB polymorphisms (rs632793, rs198388 and rs198389) were associated with reduced risk of LVD in CAD patients with HLP. 25400811 2014
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C1956346
Disease:
Coronary Artery Disease
0.010 GeneticVariation BEFREE Three NPPA-NPPB polymorphisms (rs632793, rs198388 and rs198389) were associated with reduced risk of LVD in CAD patients with HLP. 25400811 2014
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0020473
Disease:
Hyperlipidemia
0.010 GeneticVariation BEFREE Subgroup analyses performed by hyperlipidemia (HLP) demonstrated 3 polymorphisms, rs632793 (OR = 0.31, 95% CI 0.1-0.93, P = 0.04), rs198388 (OR = 0.26, 95% CI 0.09-0.79, P = 0.02) and rs198389 (OR = 0.26, 95% CI 0.09-0.80, P = 0.02) were associated with the reduced risk of LVD. 25400811 2014
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0263420
Disease:
Hyperkeratosis lenticularis perstans
0.010 GeneticVariation BEFREE Three NPPA-NPPB polymorphisms (rs632793, rs198388 and rs198389) were associated with reduced risk of LVD in CAD patients with HLP. 25400811 2014
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0035067
Disease:
Renal Artery Stenosis
0.010 GeneticVariation BEFREE We demonstrated the association between SNP rs198389 (T-381 C) polymorphism in the BNP gene promoter and the degree of RAS in patients with atherosclerotic renovascular hypertension. 19413180 2009
dbSNP: rs198389
rs198389
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0020545
Disease:
Hypertension, Renovascular
0.010 GeneticVariation BEFREE We demonstrated the association between SNP rs198389 (T-381 C) polymorphism in the BNP gene promoter and the degree of RAS in patients with atherosclerotic renovascular hypertension. 19413180 2009