OGG1, 8-oxoguanine DNA glycosylase, 4968

N. diseases: 313; N. variants: 38
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104893751
rs104893751
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
CUI: C0279702
Disease:
Conventional (Clear Cell) Renal Cell Carcinoma
A 0.700 CausalMutation CLINVAR
dbSNP: rs907102077
rs907102077
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0278883
Disease:
Metastatic melanoma
0.700 GeneticVariation UNIPROT
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Among the results for 57 SNPs and 2 gene deletions, rs1056827 in CYP1B1, rs2959008 and rs7173655 in CYP11A1, the GSTT1 gene deletion, and rs1052133 in hOGG1 showed a statistically significant interaction with acrylamide intake for ER+ breast cancer risk. 29445914 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.100 GeneticVariation BEFREE This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. 30429230 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655). 31584889 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0684249
Disease:
Carcinoma of lung
0.100 GeneticVariation BEFREE To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure. 31446980 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.100 GeneticVariation BEFREE To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure. 31446980 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.100 GeneticVariation BEFREE Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655). 31584889 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0684249
Disease:
Carcinoma of lung
0.100 GeneticVariation BEFREE Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655). 31584889 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure. 31446980 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE Among the results for 57 SNPs and 2 gene deletions, rs1056827 in CYP1B1, rs2959008 and rs7173655 in CYP11A1, the GSTT1 gene deletion, and rs1052133 in hOGG1 showed a statistically significant interaction with acrylamide intake for ER+ breast cancer risk. 29445914 2019
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk. 29720094 2018
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet. 29305130 2018
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE This study suggested that the carrier of Ser326Cys polymorphism of hOGG1, Cys/Cys vs Ser/Ser, are at higher risk for breast cancer, independent of other hormonal and environmental risk factors. 28608470 2018
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE In contrast to the CC and CG genotypes, the GG genotype of rs1052133 located on theOGG1 gene appeared to be a protective factor against developing breast cancer in both Mongoloid and Caucasoid populations. 29662639 2018
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C1306459
Disease:
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet. 29305130 2018
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE In contrast to the CC and CG genotypes, the GG genotype of rs1052133 located on theOGG1 gene appeared to be a protective factor against developing breast cancer in both Mongoloid and Caucasoid populations. 29662639 2018
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE This study suggested that the carrier of Ser326Cys polymorphism of hOGG1, Cys/Cys vs Ser/Ser, are at higher risk for breast cancer, independent of other hormonal and environmental risk factors. 28608470 2018
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk. 29720094 2018
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE The 127 studies including 38,757 cancer patients and 50,177 control subjects were analyzed for the meta-analysis.Our meta-analysis revealed that G allele of Ser326Cys polymorphism of the hOGG1 gene statistically increased the susceptibility of cancer (all population, OR = 1.092, 95% CI = 1.051-1.134, p < 0.001; in Asian, OR = 1.095, 95% CI = 1.048-1.145, p < 0.001; in Caucasian, OR = 1.097, 95% CI = 1.033-1.179, p = 0.002). 28415770 2017
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C1306459
Disease:
Primary malignant neoplasm
0.100 GeneticVariation BEFREE The 127 studies including 38,757 cancer patients and 50,177 control subjects were analyzed for the meta-analysis.Our meta-analysis revealed that G allele of Ser326Cys polymorphism of the hOGG1 gene statistically increased the susceptibility of cancer (all population, OR = 1.092, 95% CI = 1.051-1.134, p < 0.001; in Asian, OR = 1.095, 95% CI = 1.048-1.145, p < 0.001; in Caucasian, OR = 1.097, 95% CI = 1.033-1.179, p = 0.002). 28415770 2017
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0006826
Disease:
Malignant Neoplasms
0.100 GeneticVariation BEFREE Our findings showed that hOGG1-Ser326Cys Cys allele is statistically important and relevant with respect to the development of oral squamous cancer. 28448977 2017
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0699791
Disease:
Stomach Carcinoma
0.100 GeneticVariation BEFREE This meta-analysis showed there was no association between hOGG1 rs1052133 and GC. 28415729 2017
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE The hOGG1 SNP rs1052133 (Ser326Cys) minor allele T showed a significant association with breast cancer samples (OR = 1.78, χ2 = 7.86, p = 0.02024). 27822728 2017
dbSNP: rs1052133
rs1052133
Entrez Id: 4968;8536
Gene Symbol: OGG1;CAMK1
OGG1;CAMK1
CUI: C1306459
Disease:
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Our findings showed that hOGG1-Ser326Cys Cys allele is statistically important and relevant with respect to the development of oral squamous cancer. 28448977 2017