TLR8, toll like receptor 8, 51311

N. diseases: 122; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1569113445
rs1569113445
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C3887876
Disease:
OSTEOARTHRITIS SUSCEPTIBILITY 1
C 0.700 GeneticVariation CLINVAR
dbSNP: rs1569113447
rs1569113447
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C3887876
Disease:
OSTEOARTHRITIS SUSCEPTIBILITY 1
A 0.700 GeneticVariation CLINVAR
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0041327
Disease:
Tuberculosis, Pulmonary
0.030 GeneticVariation BEFREE In summary, we show an association of SNP TLR8 rs3764880 with PTB in the Moldavian male population, providing support to previous studies conducted on other populations. 30529560 2019
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0019196
Disease:
Hepatitis C
0.030 GeneticVariation BEFREE TLR8 rs3764880-G allele was associated with spontaneous HCV clearance in both sexes (P < .0001) albeit with an apparently stronger association in males (OR = 6.02 for men vs 2.2 for women). 28752959 2018
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0041327
Disease:
Tuberculosis, Pulmonary
0.030 GeneticVariation BEFREE The AA genotype of rs3764880 SNP was found to increase the risk of PTB among females with an OR of 4.81 (1.11-20.85). 30424735 2018
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0019196
Disease:
Hepatitis C
0.030 GeneticVariation BEFREE The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes. 29947302 2018
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0019196
Disease:
Hepatitis C
0.030 GeneticVariation BEFREE Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls. 24205871 2014
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0041327
Disease:
Tuberculosis, Pulmonary
0.030 GeneticVariation BEFREE We found a strong association with genotype A/(-) at rs3764880 with susceptibility to pulmonary TB in males (OR 2.87, 95%CI 1.38-5.98, p=0.007). 21846947 2011
dbSNP: rs3764879
rs3764879
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0019196
Disease:
Hepatitis C
0.020 GeneticVariation BEFREE The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes. 29947302 2018
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0041296
Disease:
Tuberculosis
0.020 GeneticVariation BEFREE The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91). 30424735 2018
dbSNP: rs3764879
rs3764879
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.020 GeneticVariation BEFREE No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756, P = 0.002). 26762473 2016
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.020 GeneticVariation BEFREE No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756, P = 0.002). 26762473 2016
dbSNP: rs3764879
rs3764879
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.020 GeneticVariation BEFREE Additionally, an association between the rs3764879 polymorphism of TLR8 and SLE (G vs. C, P < 0.05, OR 1.36, 95 % CI 0.99-1.86 in females; P = 0.06, OR 4.00, 95 % CI 0.90-17.3 in males) was found. 24919757 2014
dbSNP: rs3764879
rs3764879
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0019196
Disease:
Hepatitis C
0.020 GeneticVariation BEFREE Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls. 24205871 2014
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.020 GeneticVariation BEFREE The "G-G" haplotype of TLR7 rs3853839 and TLR8 rs3764880 increased risk of SLE in females (age adjusted p = 0.0032). 24445780 2014
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0041296
Disease:
Tuberculosis
0.020 GeneticVariation BEFREE We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous polymorphism rs3764880 (Met1Val; P = 0.007, odds ratio (OR) = 1.8, 95% c.i.= 1.2-2.7). 18927625 2008
dbSNP: rs3761624
rs3761624
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0027651
Disease:
Neoplasms
0.010 GeneticVariation BEFREE We previously reported that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polymorphism (SNP) (rs3761624) in the TLR8 promoter, thereby placing TLR8 in the p53/immune axis. 31430261 2019
dbSNP: rs3764879
rs3764879
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0031099
Disease:
Periodontitis
0.010 GeneticVariation BEFREE This study demonstrated an association between TLR1-rs5743611, TLR4-rs7873784, TLR7-rs3853839, and TLR8-rs3764879 and susceptibility to periodontitis in adolescents. 30517775 2019
dbSNP: rs3764879
rs3764879
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C1861453
Disease:
Pseudohyperkalemia Cardiff
0.010 GeneticVariation BEFREE Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001). 29947302 2018
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0151332
Disease:
Active tuberculosis
0.010 GeneticVariation BEFREE The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91). 30424735 2018
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C1861453
Disease:
Pseudohyperkalemia Cardiff
0.010 GeneticVariation BEFREE Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001). 29947302 2018
dbSNP: rs2407992
rs2407992
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0006271
Disease:
Bronchiolitis
0.010 GeneticVariation BEFREE There were no significant associations between the genotypes or allele frequencies of TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and clinical characteristics or the severity of bronchiolitis during hospitalization. 27498757 2016
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0948008
Disease:
Ischemic stroke
0.010 GeneticVariation BEFREE Therefore, TLR8 gene rs3764880 polymorphism might be associated with susceptibility and involved in the inflammatory reaction and lipid metabolism of IS in southern Chinese Han. 27772795 2016
dbSNP: rs1013151
rs1013151
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0019196
Disease:
Hepatitis C
0.010 GeneticVariation BEFREE When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively]. 26455634 2015
dbSNP: rs2407992
rs2407992
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0014378
Disease:
Enterovirus Infections
0.010 GeneticVariation BEFREE The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02). 26485223 2015