rs1569113445
|
TLR8;TLR8-AS1
|
OSTEOARTHRITIS SUSCEPTIBILITY 1
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1569113447
|
TLR8;TLR8-AS1
|
OSTEOARTHRITIS SUSCEPTIBILITY 1
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, we show an association of SNP TLR8 rs3764880 with PTB in the Moldavian male population, providing support to previous studies conducted on other populations.
|
30529560 |
2019 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
TLR8 rs3764880-G allele was associated with spontaneous HCV clearance in both sexes (P < .0001) albeit with an apparently stronger association in males (OR = 6.02 for men vs 2.2 for women).
|
28752959 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation |
BEFREE |
The AA genotype of rs3764880 SNP was found to increase the risk of PTB among females with an OR of 4.81 (1.11-20.85).
|
30424735 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
|
29947302 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.030 |
GeneticVariation |
BEFREE |
Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls.
|
24205871 |
2014 |
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation |
BEFREE |
We found a strong association with genotype A/(-) at rs3764880 with susceptibility to pulmonary TB in males (OR 2.87, 95%CI 1.38-5.98, p=0.007).
|
21846947 |
2011 |
rs3764879
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
|
29947302 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
rs3764879
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756, P = 0.002).
|
26762473 |
2016 |
rs3764880
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was detected between rs3764880 (TLR8) and SLE; however, our meta-analysis indicated an association between rs3764879 (TLR8) and SLE in Caucasians (OR = 1.414, 95% CI = 1.139-1.756, P = 0.002).
|
26762473 |
2016 |
rs3764879
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, an association between the rs3764879 polymorphism of TLR8 and SLE (G vs. C, P < 0.05, OR 1.36, 95 % CI 0.99-1.86 in females; P = 0.06, OR 4.00, 95 % CI 0.90-17.3 in males) was found.
|
24919757 |
2014 |
rs3764879
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.020 |
GeneticVariation |
BEFREE |
Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls.
|
24205871 |
2014 |
rs3764880
|
TLR8;TLR8-AS1
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation |
BEFREE |
The "G-G" haplotype of TLR7 rs3853839 and TLR8 rs3764880 increased risk of SLE in females (age adjusted p = 0.0032).
|
24445780 |
2014 |
rs3764880
|
TLR8;TLR8-AS1
|
Tuberculosis
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous polymorphism rs3764880 (Met1Val; P = 0.007, odds ratio (OR) = 1.8, 95% c.i.= 1.2-2.7).
|
18927625 |
2008 |
rs3761624
|
TLR8;TLR8-AS1
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
We previously reported that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polymorphism (SNP) (rs3761624) in the TLR8 promoter, thereby placing TLR8 in the p53/immune axis.
|
31430261 |
2019 |
rs3764879
|
TLR8;TLR8-AS1
|
Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrated an association between TLR1-rs5743611, TLR4-rs7873784, TLR7-rs3853839, and TLR8-rs3764879 and susceptibility to periodontitis in adolescents.
|
30517775 |
2019 |
rs3764879
|
TLR8;TLR8-AS1
|
Pseudohyperkalemia Cardiff
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001).
|
29947302 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Active tuberculosis
|
|
0.010 |
GeneticVariation |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
rs3764880
|
TLR8;TLR8-AS1
|
Pseudohyperkalemia Cardiff
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001).
|
29947302 |
2018 |
rs2407992
|
TLR8;TLR8-AS1
|
Bronchiolitis
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no significant associations between the genotypes or allele frequencies of TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and clinical characteristics or the severity of bronchiolitis during hospitalization.
|
27498757 |
2016 |
rs3764880
|
TLR8;TLR8-AS1
|
Ischemic stroke
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, TLR8 gene rs3764880 polymorphism might be associated with susceptibility and involved in the inflammatory reaction and lipid metabolism of IS in southern Chinese Han.
|
27772795 |
2016 |
rs1013151
|
TLR8;TLR8-AS1
|
Hepatitis C
|
|
0.010 |
GeneticVariation |
BEFREE |
When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively].
|
26455634 |
2015 |
rs2407992
|
TLR8;TLR8-AS1
|
Enterovirus Infections
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
|
26485223 |
2015 |