rs75932628
|
TREM2;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.080 |
GeneticVariation |
BEFREE |
Our findings suggest that the rs75932628-T variant of TREM2 is an important risk factor for LOAD in the Colombian population.
|
30222607 |
2019 |
rs75932628
|
TREM2;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.080 |
GeneticVariation |
BEFREE |
We did not find an association between the rs75932628</span> single nucleotide polymorphism of TREM2 and LOAD in this study.
|
29256968 |
2018 |
rs75932628
|
TREM2;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.080 |
GeneticVariation |
BEFREE |
The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular basis of R47H TREM2 loss of function is an emerging area of TREM2 biology.
|
29794134 |
2018 |
rs75932628
|
TREM2;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.080 |
GeneticVariation |
BEFREE |
The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease.
|
30185230 |
2018 |
rs75932628
|
TREM2;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.080 |
GeneticVariation |
BEFREE |
Here, we present more evidence for the association of the R47H with LOAD risk in a Caucasian population comprising 4567 LOAD cases and controls.
|
26058841 |
2015 |
rs75932628
|
TREM2;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.080 |
GeneticVariation |
BEFREE |
Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population.
|
24725293 |
2014 |
rs75932628
|
TREM2;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.080 |
GeneticVariation |
BEFREE |
Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95% CI, 1.3 to 16.9; p = 0.009).
|
23380991 |
2013 |
rs75932628
|
TREM2;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.080 |
GeneticVariation |
BEFREE |
Recent works have demonstrated a rare functional variant (R47H) in triggering receptor expressed on myeloid cells (TREM) 2 gene, encoding TREM2 protein, increase susceptibility to late-onset Alzheimer's disease (AD), with an odds ratio similar to that of the apolipoprotein E ε4 allele.
|
23407992 |
2013 |
rs2234256
|
TREM2;TREML1;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified significant LOAD risk association with p.L211P (p=0.01, OR=1.27, 95%CI=1.05-1.54) and suggestive association with p.W191X (p=0.08, OR=1.35, 95%CI=0.97-1.87).
|
25886450 |
2015 |
rs2234258
|
TREM2;TREML1;LOC105375056
|
Alzheimer Disease, Late Onset
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified significant LOAD risk association with p.L211P (p=0.01, OR=1.27, 95%CI=1.05-1.54) and suggestive association with p.W191X (p=0.08, OR=1.35, 95%CI=0.97-1.87).
|
25886450 |
2015 |