MAPK8, mitogen-activated protein kinase 8, 5599

N. diseases: 520; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1348073540
rs1348073540
Entrez Id: 5599;58504
Gene Symbol: MAPK8;ARHGAP22
MAPK8;ARHGAP22
CUI: C0949664
Disease:
Tauopathies
0.010 GeneticVariation BEFREE The Stress c-Jun N-terminal Kinase Signaling Pathway Activation Correlates with Synaptic Pathology and Presents A Sex Bias in P301L Mouse Model of Tauopathy. 30315879 2018
dbSNP: rs17780725
rs17780725
Entrez Id: 5599
Gene Symbol: MAPK8
MAPK8
CUI: C0019163
Disease:
Hepatitis B
0.010 GeneticVariation BEFREE The MAPK8 rs17780725 AA genotype increased the risk of low response to hepatitis B vaccines (OR = 3.176, 95% CI: 1.137-8.869). 29898681 2018
dbSNP: rs10857560
rs10857560
Entrez Id: 5599
Gene Symbol: MAPK8
MAPK8
CUI: C3696954
Disease:
Precapillary pulmonary hypertension
0.010 GeneticVariation BEFREE The homozygous AA genotype of rs10857560 was associated with decreased MAPK8 expression and present in all 14 of the identified precapillary pulmonary hypertension cases among the combined 757 patients. 24515990 2014
dbSNP: rs10857561
rs10857561
Entrez Id: 5599
Gene Symbol: MAPK8
MAPK8
CUI: C0007113
Disease:
Rectal Carcinoma
0.010 GeneticVariation BEFREE DUSP1 rs322351 (OR = 1.43, 95% CI = 1.09, 1.88; TT versus CC) and MAPK8 rs10857561 (OR = 1.48, 95% CI 1.08, 2.03; AA versus GG/GA) were associated with rectal cancer (P (adj) < 0.05). 23027623 2012