RELN, reelin, 5649

N. diseases: 178; N. variants: 52
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7341475
rs7341475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease:
Schizophrenia 		0.860 GeneticVariation BEFREE In conclusion, there was only association between the RELN rs7341475 variant and schiz</span>ophrenia in the female gender in a Turkish population. 30980267 2019
dbSNP: rs7341475
rs7341475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease:
Schizophrenia 		0.860 GeneticVariation BEFREE We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, OR=1.26, 95% CI=1.13-1.41, P<0.01, FDR<0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, OR=0.88, 95% CI=0.82-0.95, P<0.01, FDR<0.01). 28506622 2017
dbSNP: rs7341475
rs7341475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease:
Schizophrenia 		0.860 GeneticVariation BEFREE Subgroup analysis indicates that the association between rs7341475 and SZ is only significant in Caucasian. 26455866 2015
dbSNP: rs7341475
rs7341475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease:
Schizophrenia 		0.860 GeneticVariation BEFREE In addition, we tested the association between variation in RELN expression and rs7341475, an intronic SNP that was found to be associated with schizophrenia in women. 21603580 2011
dbSNP: rs7341475
rs7341475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease:
Schizophrenia 		0.860 GeneticVariation BEFREE A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case--control study specifically in women by Shifman et al. 20431428 2010
dbSNP: rs7341475
rs7341475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease:
Schizophrenia 		0.860 GeneticVariation BEFREE This study does not suggest a significant impact of rs7341475 on brain structure, function, and RELN expression, arguing that this single nucleotide polymorphism and others linked with it do not affect brain measures related to the biology of schizophrenia. 20434133 2010
dbSNP: rs7341475
rs7341475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease:
Schizophrenia 		G 0.860 GeneticVariation GWASCAT Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. 18282107 2008
dbSNP: rs7341475
rs7341475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease:
Schizophrenia 		G 0.860 GeneticVariation GWASDB Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. 18282107 2008
dbSNP: rs3914132
rs3914132
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0029899
Disease:
Otosclerosis 		0.810 GeneticVariation BEFREE Recently, a reelin gene, SNP rs3914132, located in intron 2, was shown to be associated with otosclerosis in a European population. 20882487 2010
dbSNP: rs3914132
rs3914132
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0029899
Disease:
Otosclerosis 		0.810 GeneticVariation GWASDB A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. 19230858 2009
dbSNP: rs3914132
rs3914132
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0029899
Disease:
Otosclerosis 		0.810 GeneticVariation GWASCAT A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. 19230858 2009
dbSNP: rs768119894
rs768119894
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C4225327
Disease:
EPILEPSY, FAMILIAL TEMPORAL LOBE, 7 		0.800 GeneticVariation UNIPROT Heterozygous reelin mutations cause autosomal-dominant lateral temporal epilepsy. 26046367 2015
dbSNP: rs768119894
rs768119894
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C4225327
Disease:
EPILEPSY, FAMILIAL TEMPORAL LOBE, 7 		C 0.800 CausalMutation CLINVAR
dbSNP: rs11496125
rs11496125
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C1305855
Disease:
Body mass index 		T 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs12375196
rs12375196
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2299383
rs2299383
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C1305855
Disease:
Body mass index 		T 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs10233848
rs10233848
Entrez Id: 5649;101927870
Gene Symbol: RELN;LOC101927870
RELN;LOC101927870
CUI: C0596887
Disease:
mathematical ability 		A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs114684479
rs114684479
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0376532
Disease:
Epilepsy, Rolandic 		T 0.700 CausalMutation CLINVAR Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy. 29358611 2018
dbSNP: rs115035120
rs115035120
Entrez Id: 5649;101927870
Gene Symbol: RELN;LOC101927870
RELN;LOC101927870
CUI: C0376532
Disease:
Epilepsy, Rolandic 		T 0.700 CausalMutation CLINVAR Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy. 29358611 2018
dbSNP: rs200124755
rs200124755
Entrez Id: 5649;101927870
Gene Symbol: RELN;LOC101927870
RELN;LOC101927870
CUI: C0376532
Disease:
Epilepsy, Rolandic 		G 0.700 CausalMutation CLINVAR Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy. 29358611 2018
dbSNP: rs2041475
rs2041475
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0040420
Disease:
Tonometry 		C 0.700 GeneticVariation GWASCAT Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. 29785010 2018
dbSNP: rs2299383
rs2299383
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.700 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
dbSNP: rs369993428
rs369993428
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0376532
Disease:
Epilepsy, Rolandic 		C 0.700 CausalMutation CLINVAR Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy. 29358611 2018
dbSNP: rs6965019
rs6965019
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C1837461
Disease:
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs6965019
rs6965019
Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0410702
Disease:
Adolescent idiopathic scoliosis 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018