REN, renin, 5972

N. diseases: 721; N. variants: 25
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121917743
rs121917743
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C2751310
Disease:
Hyperuricemic Nephropathy, Familial Juvenile 2 		0.800 GeneticVariation UNIPROT Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. 19664745 2009
dbSNP: rs121917742
rs121917742
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0266313
Disease:
Allanson Pantzar McLeod syndrome 		0.800 GeneticVariation UNIPROT Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. 16116425 2005
dbSNP: rs121917742
rs121917742
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0266313
Disease:
Allanson Pantzar McLeod syndrome 		T 0.800 CausalMutation CLINVAR
dbSNP: rs121917743
rs121917743
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C2751310
Disease:
Hyperuricemic Nephropathy, Familial Juvenile 2 		T 0.800 GeneticVariation CLINVAR
dbSNP: rs121917743
rs121917743
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C2751310
Disease:
Hyperuricemic Nephropathy, Familial Juvenile 2 		C 0.800 CausalMutation CLINVAR
dbSNP: rs72749713
rs72749713
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs193280350
rs193280350
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C2985280
Disease:
Blood Protein Measurement 		A 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs12040249
rs12040249
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs11571111
rs11571111
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0428472
Disease:
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs11571111
rs11571111
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs11571111
rs11571111
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs11571111
rs11571111
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C1445957
Disease:
Serum total cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs6668858
rs6668858
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs6668858
rs6668858
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0428472
Disease:
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs6668858
rs6668858
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs6668858
rs6668858
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C1445957
Disease:
Serum total cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs121917740
rs121917740
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C4016362
Disease:
HYPERPRORENINEMIA, FAMILIAL 		A 0.700 CausalMutation CLINVAR
dbSNP: rs121917741
rs121917741
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0266313
Disease:
Allanson Pantzar McLeod syndrome 		A 0.700 CausalMutation CLINVAR
dbSNP: rs397514690
rs397514690
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0266313
Disease:
Allanson Pantzar McLeod syndrome 		A 0.700 CausalMutation CLINVAR
dbSNP: rs397514691
rs397514691
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0266313
Disease:
Allanson Pantzar McLeod syndrome 		T 0.700 CausalMutation CLINVAR
dbSNP: rs868694193
rs868694193
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0266313
Disease:
Allanson Pantzar McLeod syndrome 		0.700 GeneticVariation UNIPROT
dbSNP: rs777208537
rs777208537
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0020538
Disease:
Hypertensive disease 		0.030 GeneticVariation BEFREE In addition to these polymorphisms, the T(-344)C polymorphism in the promoter of the aldosterone synthase gene (CYP11B2) and the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) are considered candidates for the genetic risk of salt-sensitive hypertension. 12924618 2003
dbSNP: rs777208537
rs777208537
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0020538
Disease:
Hypertensive disease 		0.030 GeneticVariation BEFREE A functional single-nucleotide variant of the gene encoding the beta3 subunit of heterotrimeric G proteins (Gbeta3 C825T), associated with enhanced G-protein activation and increased activity of the sodium-proton exchanger (NHE1), has been implicated in the development of hypertension. 10930182 2000
dbSNP: rs777208537
rs777208537
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0020538
Disease:
Hypertensive disease 		0.030 GeneticVariation BEFREE Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks. 10601117 1999
dbSNP: rs2368564
rs2368564
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0085580
Disease:
Essential Hypertension 		0.010 GeneticVariation BEFREE The genotypic and allelic distributions of rs2368564 in essential hypertension and control was significant statistically ( p<0.001). 29233044 2018