CCL5, C-C motif chemokine ligand 5, 6352

N. diseases: 514; N. variants: 6
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C2985280
Disease:
Blood Protein Measurement
C 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0041296
Disease:
Tuberculosis
0.020 GeneticVariation BEFREE Many case-control studies have been performed in the recent past to investigate the association between CCL5 -403 G>A (rs2107538) gene polymorphism and tuberculosis (TB) susceptibility in various ethnic groups. 24015211 2013
dbSNP: rs2280788
rs2280788
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0041296
Disease:
Tuberculosis
0.020 GeneticVariation BEFREE A genetic association study of CCL5 -28 C>G (rs2280788) polymorphism with risk of tuberculosis: a meta-analysis. 24376699 2013
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0041296
Disease:
Tuberculosis
0.020 GeneticVariation BEFREE The present study investigated the relationship between the RANTES polymorphisms (-28C/G; rs2280788, and -403G/A; rs2107538) and susceptibility to active tuberculosis (TB) in Tunisian populations. 21510799 2011
dbSNP: rs2280788
rs2280788
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0041296
Disease:
Tuberculosis
0.020 GeneticVariation BEFREE The present study investigated the relationship between the RANTES polymorphisms (-28C/G; rs2280788, and -403G/A; rs2107538) and susceptibility to active tuberculosis (TB) in Tunisian populations. 21510799 2011
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Novel associations of the polymorphic loci in CCL20 (rs6749704) and CCL5 (rs2107538) genes with type 2 diabetes had been identified as a result of the conducted research. 30536157 2019
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C1704272
Disease:
Benign Prostatic Hyperplasia
0.010 GeneticVariation BEFREE The CCL5 rs2107538 polymorphism was identified to be associated with a significantly lower risk of BPH [A/G vs. G/G: odds ratio (OR)=0.37, 95% confidence interval (CI)=0.17‑0.78; A/A + A/G vs. G/G: OR=0.39, 95% CI=0.19‑0.79; A vs. G: OR=0.58, 95% CI=0.35‑0.96). 30816510 2019
dbSNP: rs3817655
rs3817655
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0019196
Disease:
Hepatitis C
0.010 GeneticVariation BEFREE Susceptibility to HCV infection is associated with A alleles of both (rs743660 and rs1799864 G/A) of CCR2 while spontaneous clearance of HCV is associated with the C allele of rs13900 of CCL2 and T allele of rs3817655 of CCL5. 30175654 2019
dbSNP: rs2280789
rs2280789
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0041327
Disease:
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE Regulatory role of CCL5 (rs2280789) and CXCL10 (rs56061981) gene polymorphisms on intracellular CCL5 and CXCL10 expression in pulmonary tuberculosis. 28336310 2018
dbSNP: rs2280789
rs2280789
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE The present study suggest that TT genotype of CCL5 In1.1T/C (rs2280789) polymorphism play an important role to increased CCL5 expression in T cell which may enhanced Th1 immunity and help in protection against tuberculosis. 28336310 2018
dbSNP: rs3817656
rs3817656
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0019196
Disease:
Hepatitis C
0.010 GeneticVariation BEFREE The polymorphism of CCR1 rs3733096 and CCL5 rs3817656 are associated with spontaneous clearance of HCV in Chinese Han population. 29703961 2018
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0035204
Disease:
Respiration Disorders
0.010 GeneticVariation BEFREE Polymorphisms of -403G/A (rs2107538), -28C/G (rs2280788), and In1.1T/C (rs2280789) in chemotactic chemokine ligand 5 (CCL5) have linked with many respiratory diseases. 26304916 2015
dbSNP: rs2280789
rs2280789
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0035204
Disease:
Respiration Disorders
0.010 GeneticVariation BEFREE Polymorphisms of -403G/A (rs2107538), -28C/G (rs2280788), and In1.1T/C (rs2280789) in chemotactic chemokine ligand 5 (CCL5) have linked with many respiratory diseases. 26304916 2015
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0678222
Disease:
Breast Carcinoma
0.010 GeneticVariation BEFREE The purpose of this study was to investigate whether single nucleotide polymorphisms of CCL5 -403 G>A (rs2107538) and CCR5 Δ32 genes are associated with the breast cancer (BC) risk. 25171476 2014
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.010 GeneticVariation BEFREE The purpose of this study was to investigate whether single nucleotide polymorphisms of CCL5 -403 G>A (rs2107538) and CCR5 Δ32 genes are associated with the breast cancer (BC) risk. 25171476 2014
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0238463
Disease:
Papillary thyroid carcinoma
0.010 GeneticVariation BEFREE When the genetic relationships between SNP and subgroups of PTC patients were assessed, SNP rs2107538 in CCL5 was not associated with any clinicopathologic characteristics of PTC. 23957698 2013
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0948008
Disease:
Ischemic stroke
0.010 GeneticVariation BEFREE This is a pilot study analysing association of chemokine gene polymorphisms (CXCL1, rs3117604; CXCL2, rs3806792; CCL2, rs2857656 and rs3760396; CCL5, rs2107538) in Korean patients with ischemic stroke (IS) (n = 120) and age-matched controls (n = 267). 23198952 2013
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0151332
Disease:
Active tuberculosis
0.010 GeneticVariation BEFREE The present study investigated the relationship between the RANTES polymorphisms (-28C/G; rs2280788, and -403G/A; rs2107538) and susceptibility to active tuberculosis (TB) in Tunisian populations. 21510799 2011
dbSNP: rs2280788
rs2280788
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0151332
Disease:
Active tuberculosis
0.010 GeneticVariation BEFREE The present study investigated the relationship between the RANTES polymorphisms (-28C/G; rs2280788, and -403G/A; rs2107538) and susceptibility to active tuberculosis (TB) in Tunisian populations. 21510799 2011
dbSNP: rs2107538
rs2107538
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent
0.010 GeneticVariation BEFREE We tested RANTES as a candidate gene for association with T1D using three single-nucleotide polymorphism (SNP) variants (rs4251719, rs2306630 and rs2107538) to capture haplotype information. 16855620 2006
dbSNP: rs766662990
rs766662990
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C2363741
Disease:
HIV-1 infection
0.010 GeneticVariation BEFREE Four SNPs (CCR2-V64I, CCR5-2459, MIP1A+954, and IL2+3896) and specific haplotypes in the IL2 and CCR2/CCR5 regions were significantly associated with HIV-1 infection susceptibility in different genetic models. 16323127 2006
dbSNP: rs766662990
rs766662990
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0003165
Disease:
Anthracosis
0.010 GeneticVariation BEFREE Associations of polymorphisms in CCL5 (G-403A) and its receptor CCR5 (Delta32), CCL2 (A-2578G) and CCR2 (V64I), and CX3CR1 V249I and T280M with coal worker's pneumoconiosis (CWP) were investigated in 209 miners examined in 1990, 1994 and 1999. 16524739 2006
dbSNP: rs766662990
rs766662990
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset
0.010 GeneticVariation BEFREE We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD. 15488313 2004
dbSNP: rs766662990
rs766662990
Entrez Id: 6352;105371744
Gene Symbol: CCL5;LOC105371744
CCL5;LOC105371744
CUI: C0030567
Disease:
Parkinson Disease
0.010 GeneticVariation BEFREE We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD. 15488313 2004