SLC2A4, solute carrier family 2 member 4, 6517

N. diseases: 158; N. variants: 7
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5418
rs5418
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0871470
Disease:
Systolic Pressure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs5417
rs5417
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0428883
Disease:
Diastolic blood pressure
A 0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. 28135244 2017
dbSNP: rs121434581
rs121434581
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation UNIPROT Recommendations from the EGAPP Working Group: does genomic profiling to assess type 2 diabetes risk improve health outcomes? 23492873 2013
dbSNP: rs121434581
rs121434581
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation UNIPROT Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. 22962670 2012
dbSNP: rs2073476
rs2073476
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0202236
Disease:
Triglycerides measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs121434581
rs121434581
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation UNIPROT Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population. 1521731 1992
dbSNP: rs121434581
rs121434581
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation UNIPROT Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus. 1918382 1991
dbSNP: rs121434581
rs121434581
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation UNIPROT Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. 1756912 1991
dbSNP: rs5435
rs5435
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0085207
Disease:
Gestational Diabetes
0.010 GeneticVariation BEFREE The gene-gene interaction analysis showed that, compared with pregnant women with other genotype combinations, women with <i>SLC2A4</i> rs5435 (CC/CT), <i>RBP4</i> rs7091052 (CC), <i>PCK1</i> rs1042531 (TT/TG) and rs2236745 (TT), and <i>PIK3R1</i> rs34309 (AA) had lower GDM risk. 30805369 2019
dbSNP: rs5435
rs5435
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent
0.010 GeneticVariation BEFREE The polymorphisms rs187238 and rs5435 were not associated with T1D in the studied population. 28973736 2017
dbSNP: rs775018856
rs775018856
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0271650
Disease:
Impaired glucose tolerance
0.010 GeneticVariation BEFREE Using physiological tests and a biophysics approach based on nuclear magnetic resonance (NMR), we unexpectedly found that SOD1(G93A) ALS mice suffered from severe glucose intolerance, which was counteracted by high intensity swimming but not moderate intensity running exercise. 29104532 2017
dbSNP: rs775018856
rs775018856
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.010 GeneticVariation BEFREE Using physiological tests and a biophysics approach based on nuclear magnetic resonance (NMR), we unexpectedly found that SOD1(G93A) ALS mice suffered from severe glucose intolerance, which was counteracted by high intensity swimming but not moderate intensity running exercise. 29104532 2017
dbSNP: rs5417
rs5417
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0520679
Disease:
Sleep Apnea, Obstructive
0.010 GeneticVariation BEFREE Frequencies of C haplotype of rs5417 in OSAS were higher than in controls. 24410986 2014
dbSNP: rs5435
rs5435
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0520679
Disease:
Sleep Apnea, Obstructive
0.010 GeneticVariation BEFREE Haplotype H1 (TCC) and H3 (CCC) defined as SNPrs5415, rs4517 and rs5435 are marginally associated with OSAS (P < 0.05). 24410986 2014
dbSNP: rs5418
rs5418
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011847
Disease:
Diabetes
0.010 GeneticVariation BEFREE The rs5418 and rs5421 polymorphisms did not show any association with diabetes. 21668369 2011
dbSNP: rs5418
rs5418
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011849
Disease:
Diabetes Mellitus
0.010 GeneticVariation BEFREE The rs5418 and rs5421 polymorphisms did not show any association with diabetes. 21668369 2011
dbSNP: rs5421
rs5421
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011849
Disease:
Diabetes Mellitus
0.010 GeneticVariation BEFREE The rs5418 and rs5421 polymorphisms did not show any association with diabetes. 21668369 2011
dbSNP: rs5421
rs5421
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011847
Disease:
Diabetes
0.010 GeneticVariation BEFREE The rs5418 and rs5421 polymorphisms did not show any association with diabetes. 21668369 2011
dbSNP: rs5435
rs5435
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011847
Disease:
Diabetes
0.010 GeneticVariation BEFREE The rs5435 [Asn130Asn(C→T)] polymorphism was found to be associated with diabetes, with the odds ratio for the CT+TT genotype being 1.26 (95% confidence interval, 1.00-1.57; P=0.043) when the CC genotype was taken as reference. 21668369 2011
dbSNP: rs5435
rs5435
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE The rs5435 (C→T) polymorphism of the GLUT4 gene is associated with type 2 diabetes in this south Indian population. 21668369 2011
dbSNP: rs5435
rs5435
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011849
Disease:
Diabetes Mellitus
0.010 GeneticVariation BEFREE The rs5435 [Asn130Asn(C→T)] polymorphism was found to be associated with diabetes, with the odds ratio for the CT+TT genotype being 1.26 (95% confidence interval, 1.00-1.57; P=0.043) when the CC genotype was taken as reference. 21668369 2011