SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0451641
Disease:
Urolithiasis
0.020 GeneticVariation BEFREE Overall, a significantly increased risk of urolithiasis was associated with OPN gene polymorphism rs1126616 for all the genetic models except recessive model. 25785266 2015
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.020 GeneticVariation BEFREE The C allele of OPN rs1126616 and the CC haplotype were significantly higher in CRC patient (p = 0.036, 0.003, respectively). 28095066 2017
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.020 GeneticVariation BEFREE Our results suggested that the rs9138 and rs1126616 of OPN were associated with CRC risk, and the OPN protein in plasma may be a potential tumor marker of CRC. 23952692 2013
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0451641
Disease:
Urolithiasis
0.020 GeneticVariation BEFREE Recently, OPN Ala250 (rs1126616) polymorphism and other single nucleotide polymorphisms (SNPs) have been studied to define their role in urolithiasis. 23692545 2013
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.020 GeneticVariation BEFREE The aim of the study was to investigate the association of genotypes and alleles frequencies of OPN 9250 (rs1126616) and IL-17A 197 (rs2275913) genes polymorphisms with their serum levels, susceptibility, disease activity and severity in Egyptian SLE patients. 30898714 2019
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.020 GeneticVariation BEFREE A silent polymorphism (707C>T, rs1126616) of osteopontin was significantly associated with SLE. 11933203 2002
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C1561643
Disease:
Chronic Kidney Diseases
0.010 GeneticVariation BEFREE We found that the rs1126616 single nucleotide polymorphism (SNP) of the <i>SPP1</i> gene is independently associated with a higher incidence of CVE in a cohort of CKD patients and that it could be used to predict CVE risk. 31036794 2019
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017661
Disease:
IGA Glomerulonephritis
0.010 GeneticVariation BEFREE The frequency of the minor TT/CT genotypes of rs1126616 was significantly higher in I</span>gAN patients compared to controls (P = 0.0217). 31159229 2019
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0596263
Disease:
Carcinogenesis
0.010 GeneticVariation BEFREE Our findings suggest a significant role played by OPN (rs9138 and rs1126616) in colorectal carcinogenesis. 28095066 2017
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0007789
Disease:
Cerebral Palsy
0.010 GeneticVariation BEFREE We found an association between rs1126616 and global CP (corrected allelic P = 0.0006 and genotypic P = 0.0011 after Bonferroni correction). 27114095 2016
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027651
Disease:
Neoplasms
0.010 GeneticVariation BEFREE Our results suggested that the rs9138 and rs1126616 of OPN were associated with CRC risk, and the OPN protein in plasma may be a potential tumor marker of CRC. 23952692 2013
dbSNP: rs1126772
rs1126772
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0699791
Disease:
Stomach Carcinoma
0.010 GeneticVariation BEFREE OPN variant rs1126772A>G and CD44 variant rs353639A>C significantly contributed to elevated risk of gastric cancer (P = 0.042, OR 1.279, 95 % CI 1.008-1.622 and P = 0.047, OR 1.334, 95 % CI 1.003-1.772). 25009318 2014
dbSNP: rs1126772
rs1126772
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0004943
Disease:
Behcet Syndrome
0.010 GeneticVariation BEFREE SNP analysis indicated an increased frequency of the OPN rs1126772 A allele in BD patients compared with controls. 21513757 2011
dbSNP: rs1126772
rs1126772
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE OPN variant rs1126772A>G and CD44 variant rs353639A>C significantly contributed to elevated risk of gastric cancer (P = 0.042, OR 1.279, 95 % CI 1.008-1.622 and P = 0.047, OR 1.334, 95 % CI 1.003-1.772). 25009318 2014
dbSNP: rs1126772
rs1126772
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003165
Disease:
Anthracosis
0.010 GeneticVariation BEFREE Our results indicate that three functional SNPs (MMP-7 rs10502001, OPN rs11728697 and OPN rs1126772) are associated with an increased risk of CWP in a Chinese population. 26330178 2015
dbSNP: rs1126772
rs1126772
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027651
Disease:
Neoplasms
0.010 GeneticVariation BEFREE Clinical data indicated that rs4754 and rs9138 of OPN were significantly associated with smoking (P = 0.029, OR 0.343, 95 % CI 0.127-0.926 and P = 0.029, OR 0.343, 95 %CI 0.127-0.926) and OPN rs1126772 revealed associations with tumor-node-metastasis (TNM) stage (P = 0.025, OR 1.765, 95 % CI 1.073-2.905) and tumor differentiation (P = 0.031, OR 1.722, 95 % CI 1.049-2.825). 25009318 2014
dbSNP: rs11439060
rs11439060
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.020 GeneticVariation BEFREE We demonstrate a significant contribution of the combination of SPP1 rs11439060 and rs9138 frequent alleles to risk of RA, the magnitude of the association being greater in patients negative for ACPAs. 24448344 2015
dbSNP: rs11439060
rs11439060
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.020 GeneticVariation BEFREE Patients with RA in the ESPOIR cohort underwent genotyping for SPP1 rs9138 and rs11439060. 24936586 2014
dbSNP: rs11728697
rs11728697
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0007789
Disease:
Cerebral Palsy
0.010 GeneticVariation BEFREE To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform. 27114095 2016
dbSNP: rs11728697
rs11728697
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003165
Disease:
Anthracosis
0.010 GeneticVariation BEFREE Our results indicate that three functional SNPs (MMP-7 rs10502001, OPN rs11728697 and OPN rs1126772) are associated with an increased risk of CWP in a Chinese population. 26330178 2015
dbSNP: rs11730582
rs11730582
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0035851
Disease:
Root Resorption
0.010 GeneticVariation BEFREE Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients. 23614633 2014
dbSNP: rs11730582
rs11730582
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0334037
Disease:
Intestinal metaplasia
0.010 GeneticVariation BEFREE Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). 28685609 2017
dbSNP: rs11730582
rs11730582
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C1306459
Disease:
Primary malignant neoplasm
0.010 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that OPN rs17524488 (-156 GG/G), rs11730582 (-443 T/C), and rs9138 (C/A) polymorphisms may be associated with cancer susceptibility in the Chinese population. 26369832 2015
dbSNP: rs11730582
rs11730582
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0029410
Disease:
Osteoarthritis of hip
0.010 GeneticVariation BEFREE However, as for rs11730582 (T>C), the adjusted ORs were 1.18 (95% CI 0.94-1.49, P=0.148) for allele C, 1.26 (95% CI 0.90-1.75, P=0.158) for TC, and 1.31 (95% CI 0.77-2.24, P=0.293) for CC, indicating no association of rs11730582 with hip OA risk. 25796600 2015
dbSNP: rs11730582
rs11730582
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027651
Disease:
Neoplasms
0.010 GeneticVariation BEFREE Stratification analysis showed that genotypes CT and CT+CC of rs11730582 were associated with tumor stage and lymph node metastasis (P<0.05). 24120738 2014