Variant Gene Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2853749
rs2853749
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0202239
Disease:
Uric acid measurement (procedure)
0.700 GeneticVariation GWASDB Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 23263486 2013
dbSNP: rs2853749
rs2853749
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0202239
Disease:
Uric acid measurement (procedure)
0.700 GeneticVariation GWASDB Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 20884846 2011
dbSNP: rs28357094
rs28357094
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0013264
Disease:
Muscular Dystrophy, Duchenne
0.040 GeneticVariation BEFREE We aimed to determine if polymorphisms previously associated with age at loss of independent ambulation (LoA) in DMD (rs28357094 in the SPP1 promoter, rs10880 and the VTTT/IAAM haplotype in LTBP4) also modify DCM onset. 26513582 2016
dbSNP: rs28357094
rs28357094
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0013264
Disease:
Muscular Dystrophy, Duchenne
0.040 GeneticVariation BEFREE A promoter polymorphism of the osteopontin (OPN) gene (rs28357094) has been associated with multiple inflammatory states, severity of Duchenne muscular dystrophy (DMD) and muscle size in healthy young adults. 24626632 2015
dbSNP: rs28357094
rs28357094
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0013264
Disease:
Muscular Dystrophy, Duchenne
0.040 GeneticVariation BEFREE To dissect the molecular mechanisms of increased disease severity associated with the G allele, we characterized SPP1 mRNA and protein in DMD muscle biopsies of patients with defined rs28357094 genotype. 22431140 2012
dbSNP: rs28357094
rs28357094
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0013264
Disease:
Muscular Dystrophy, Duchenne
0.040 GeneticVariation BEFREE To test the effect of the single nucleotide polymorphism -66 T>G (rs28357094) in the osteopontin gene (SPP1) on functional measures over 12 months in Duchenne muscular dystrophy (DMD). 22744661 2012
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0699791
Disease:
Stomach Carcinoma
0.020 GeneticVariation BEFREE SPP1 rs4754 and its epistatic interactions with SPARC polymorphisms in gastric cancer susceptibility. 28962925 2017
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.020 GeneticVariation BEFREE SPP1 rs4754 and its epistatic interactions with SPARC polymorphisms in gastric cancer susceptibility. 28962925 2017
dbSNP: rs11439060
rs11439060
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.020 GeneticVariation BEFREE Patients with RA in the ESPOIR cohort underwent genotyping for SPP1 rs9138 and rs11439060. 24936586 2015
dbSNP: rs11439060
rs11439060
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.020 GeneticVariation BEFREE We demonstrate a significant contribution of the combination of SPP1 rs11439060 and rs9138 frequent alleles to risk of RA, the magnitude of the association being greater in patients negative for ACPAs. 24448344 2015
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0699791
Disease:
Stomach Carcinoma
0.020 GeneticVariation BEFREE We found that the polymorphisms rs4754, rs9138 and rs1126772 of OPN gene and rs353639 of CD44 gene were significantly associated with gastric cancer. 25009318 2015
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.020 GeneticVariation BEFREE We found that the polymorphisms rs4754, rs9138 and rs1126772 of OPN gene and rs353639 of CD44 gene were significantly associated with gastric cancer. 25009318 2015
dbSNP: rs9138
rs9138
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.020 GeneticVariation BEFREE We demonstrate a significant contribution of the combination of SPP1 rs11439060 and rs9138 frequent alleles to risk of RA, the magnitude of the association being greater in patients negative for ACPAs. 24448344 2015
dbSNP: rs9138
rs9138
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.020 GeneticVariation BEFREE SPP1 rs9138 variant contributes to the severity of radiological damage in anti-citrullinated protein autoantibody-negative rheumatoid arthritis. 24936586 2015
dbSNP: rs28357094
rs28357094
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C1449563
Disease:
Cardiomyopathy, Familial Idiopathic
0.010 GeneticVariation BEFREE We observed trends towards a protective effect of the dominant G allele at SPP1 rs28357094 and recessive T allele at LTBP4 rs10880, which was statistically significant in steroid-treated patients for LTBP4 rs10880 (< 50% T/T patients developing DCM during follow-up [n = 13]; median DCM onset 17.6 years for C/C-C/T, log-rank p = 0.027). 26513582 2016
dbSNP: rs1126772
rs1126772
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE We found that the polymorphisms rs4754, rs9138 and rs1126772 of OPN gene and rs353639 of CD44 gene were significantly associated with gastric cancer. 25009318 2015
dbSNP: rs1126772
rs1126772
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0699791
Disease:
Stomach Carcinoma
0.010 GeneticVariation BEFREE We found that the polymorphisms rs4754, rs9138 and rs1126772 of OPN gene and rs353639 of CD44 gene were significantly associated with gastric cancer. 25009318 2015
dbSNP: rs9138
rs9138
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE We found that the minor alleles of OPN rs4754C>T and OPN rs9138C>A remained strongly associated with decreased gastric cancer risk (P = 1.53 × 10(-4), odds ratio (OR) 0.642, 95 % confidence interval (CI) 0.511-0.808 and P = 1.59 × 10(-4), OR 0.642, 95 %CI 0.510-0.809). 25009318 2015
dbSNP: rs9138
rs9138
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0699791
Disease:
Stomach Carcinoma
0.010 GeneticVariation BEFREE We found that the minor alleles of OPN rs4754C>T and OPN rs9138C>A remained strongly associated with decreased gastric cancer risk (P = 1.53 × 10(-4), odds ratio (OR) 0.642, 95 % confidence interval (CI) 0.511-0.808 and P = 1.59 × 10(-4), OR 0.642, 95 %CI 0.510-0.809). 25009318 2015
dbSNP: rs9138
rs9138
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE Data on rs7574865 in the STAT4 gene and rs9138 in SPP1 were replicated for associations with SLE when comparing cases and controls (corrected P values ranging from 0.0043 to 0.027). 24023622 2014
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Our results suggested that the rs9138 and rs1126616 of OPN were associated with CRC risk, and the OPN protein in plasma may be a potential tumor marker of CRC. 23952692 2013
dbSNP: rs9138
rs9138
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0009402
Disease:
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Our results suggested that the rs9138 and rs1126616 of OPN were associated with CRC risk, and the OPN protein in plasma may be a potential tumor marker of CRC. 23952692 2013
dbSNP: rs2728127
rs2728127
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0010346
Disease:
Crohn Disease
0.010 GeneticVariation BEFREE Genomic DNA from 2819 Caucasian individuals (n = 841 patients with Crohn's disease (CD), n = 473 patients with ulcerative colitis (UC), and n = 1505 healthy unrelated controls) was analyzed for nine OPN SNPs (rs2728127, rs2853744, rs11730582, rs11739060, rs28357094, rs4754 = p.Asp80Asp, rs1126616 = p.Ala236Ala, rs1126772 and rs9138). 22242114 2012
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0010346
Disease:
Crohn Disease
0.010 GeneticVariation BEFREE Genomic DNA from 2819 Caucasian individuals (n = 841 patients with Crohn's disease (CD), n = 473 patients with ulcerative colitis (UC), and n = 1505 healthy unrelated controls) was analyzed for nine OPN SNPs (rs2728127, rs2853744, rs11730582, rs11739060, rs28357094, rs4754 = p.Asp80Asp, rs1126616 = p.Ala236Ala, rs1126772 and rs9138). 22242114 2012
dbSNP: rs747523005
rs747523005
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease:
Neoplasm Metastasis
0.010 GeneticVariation BEFREE Expression of S100P, S100A4, osteopontin (OPN) or anterior gradient homologue 2 (AGR2) proteins can induce metastasis but fail to induce tumorigenesis per se. 22147918 2012