rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
0.870
GeneticVariation
BEFREE
The presence of (C) in rs10758669, (T) and (TT) in rs957970, and (TT) in rs744166 were found to increase the susceptibility to Crohn's disease (p=0.049, p=0.016, p=0.010, p=0.035, respectively), while rs2293152 (GC), rs744166 (CT), and rs957970 (CT) provide protection against Crohn's disease (p=0.007, p=0.043, p=0.043, respectively).
27852544
2016
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
0.870
GeneticVariation
BEFREE
Our results support an important association of rs744166 and rs4796793 with decreased CD risk, and additional interaction between rs744166 and smoking.
27022745
2016
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
0.870
GeneticVariation
BEFREE
This meta-analysis indicates that carriers of the STAT3 rs744166 'A' allele have a significantly greater risk of CD and UC, especially among Caucasians.
25286337
2014
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
0.870
GeneticVariation
BEFREE
STAT3 rs744166 and rs4796793 polymorphisms may be associated with CD occurrence and used as a predictive factor of CD in Chinese Han populations.
24885273
2014
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
0.870
GeneticVariation
BEFREE
Here, we studied the susceptibility nature of three components of IL23 signalling and Th17 cell differentiation: JAK2 rs10758669, STAT3 rs744166 and CCR6 rs2301436 initially associated with CD in Hungarian CD and UC patients.
22269120
2012
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
0.870
GeneticVariation
BEFREE
JAK2 rs10758669 and STAT3 rs744166 increase susceptibility for CD .
22065112
2012
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
0.870
GeneticVariation
BEFREE
Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166 , P = 0.01).
20222910
2010
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
A
0.870
GeneticVariation
GWASCAT
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
18587394
2008
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
A
0.870
GeneticVariation
GWASDB
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
18587394
2008
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Multiple Sclerosis
0.820
GeneticVariation
BEFREE
We observed a nominally significant, albeit weak association between rs744166 and MS susceptibility (odds ratio = 1.09, P = 0.012) in our sample.
22095036
2012
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Multiple Sclerosis
G
0.820
GeneticVariation
GWASCAT
SNP (rs744166 ) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
20159113
2010
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Multiple Sclerosis
G
0.820
GeneticVariation
GWASDB
SNP (rs744166 ) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
20159113
2010
rs744166
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Multiple Sclerosis
0.820
GeneticVariation
BEFREE
SNP (rs744166 ) within the STAT3 gene was associated to MS (p = 2.75 x 10(-10), OR 0.87, confidence interval 0.83-0.91).
20159113
2010
rs9891119
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
A
0.810
GeneticVariation
GWASDB
We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10(-59)), TNFSF15 (rs6478106, P = 3.87 × 10(-45)), and STAT3 (rs9891119 , P = 2.24 × 10(-14)).
23266558
2013
rs9891119
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
0.810
GeneticVariation
BEFREE
We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10(-59)), TNFSF15 (rs6478106, P = 3.87 × 10(-45)), and STAT3 (rs9891119 , P = 2.24 × 10(-14)).
23266558
2013
rs9891119
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Crohn Disease
A
0.810
GeneticVariation
GWASCAT
We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10(-59)), TNFSF15 (rs6478106, P = 3.87 × 10(-45)), and STAT3 (rs9891119 , P = 2.24 × 10(-14)).
23266558
2013
rs12942547
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Inflammatory Bowel Diseases
0.800
GeneticVariation
GWASCAT
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
28067908
2017
rs587777648
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
0.800
GeneticVariation
UNIPROT
An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis.
28073828
2017
rs587777649
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
0.800
GeneticVariation
UNIPROT
An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis.
28073828
2017
rs587777650
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
0.800
GeneticVariation
UNIPROT
An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis.
28073828
2017
rs869312892
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
0.800
GeneticVariation
UNIPROT
An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis.
28073828
2017
rs12942547
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
Inflammatory Bowel Diseases
G
0.800
GeneticVariation
GWASCAT
Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.
27569725
2016
rs193922721
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
0.800
GeneticVariation
UNIPROT
Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort.
26293184
2016
rs397514766
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
HYPER-IgE RECURRENT INFECTION SYNDROME 1, AUTOSOMAL DOMINANT
0.800
GeneticVariation
UNIPROT
Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort.
26293184
2016
rs869312892
×
Entrez Id:
6774
Gene Symbol:
STAT3
STAT3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
A
0.800
CausalMutation
CLINVAR
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.
25359994
2015