Allele A of the rs4853542 polymorphism in STAT4 is not associated with TB susceptibility, but we demonstrated that rs4853542A allele decreased risk of TB in younger adults after Bonferroni correction.
A single-polymorphism analysis revealed that the TT genotype of the rs7574865/T > G polymorphism was significantly more frequent in women with minimal or mild endometriosis than in the controls (10% vs. 5%, p = 0.047).
Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor.
Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor.
Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor.
We identify a locus in STAT4, rs13390936, associated with NTS bacteraemia. rs13390936 is a context-specific expression quantitative trait locus for STAT4 RNA expression, and individuals carrying the NTS-risk genotype demonstrate decreased interferon-γ (IFNγ) production in stimulated natural killer cells, and decreased circulating IFNγ concentrations during acute NTS bacteraemia.
This is the first study demonstrating the significant associations of SNP rs3077, rs9277535 and rs7574865 and the haplotypes in the HLA gene with the risk of IgAN in a Southwest Chinese population.
The strongest signals of association were observed in the cases of rs6679356 between the late-onset MG patients and controls and rs7574865 between early-onset MG and controls.
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
Furthermore, having TG + GG genotypes on rs1031509 near STAT4 was associated with 5-times (95% CI, 3.03-8.55) greater odds of asthma diagnosis at the highest B[a]P range, compared to the odds at the reference range.
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk.
We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk.
After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004).
We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk.
We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk.