Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10931481
rs10931481
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3495559
Disease:
Juvenile arthritis
0.010 GeneticVariation BEFREE SNPs at rs1018981 and rs10931481 were correlated with higher risk of polyarticular JIA. 30620272 2019
dbSNP: rs11893432
rs11893432
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3495559
Disease:
Juvenile arthritis
0.010 GeneticVariation BEFREE The G allele of rs11893432 was significantly associated with JIA risk, particularly oligoarticular JIA, in Han Chinese populations. 30620272 2019
dbSNP: rs11893432
rs11893432
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3898105
Disease:
Oligoarticular Juvenile Idiopathic Arthritis
0.010 GeneticVariation BEFREE The G allele of rs11893432 was significantly associated with JIA risk, particularly oligoarticular JIA, in Han Chinese populations. 30620272 2019
dbSNP: rs4853542
rs4853542
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE Allele A of the rs4853542 polymorphism in STAT4 is not associated with TB susceptibility, but we demonstrated that rs4853542A allele decreased risk of TB in younger adults after Bonferroni correction. 30660736 2019
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0014175
Disease:
Endometriosis
0.010 GeneticVariation BEFREE A single-polymorphism analysis revealed that the TT genotype of the rs7574865/T > G polymorphism was significantly more frequent in women with minimal or mild endometriosis than in the controls (10% vs. 5%, p = 0.047). 30887509 2019
dbSNP: rs10181656
rs10181656
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE The allelic and genotypic frequencies of rs10181656 located in the STAT4 gene were not found to be associated with risk of type 2 diabetes. 30044774 2018
dbSNP: rs11889341
rs11889341
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024138
Disease:
Lupus Erythematosus, Discoid
0.010 GeneticVariation BEFREE Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor. 29912393 2018
dbSNP: rs11889341
rs11889341
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0409974
Disease:
Lupus Erythematosus
0.010 GeneticVariation BEFREE Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor. 29912393 2018
dbSNP: rs11889341
rs11889341
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024131
Disease:
Lupus Vulgaris
0.010 GeneticVariation BEFREE Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor. 29912393 2018
dbSNP: rs13390936
rs13390936
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004610
Disease:
Bacteremia
0.010 GeneticVariation BEFREE We identify a locus in STAT4, rs13390936, associated with NTS bacteraemia. rs13390936 is a context-specific expression quantitative trait locus for STAT4 RNA expression, and individuals carrying the NTS-risk genotype demonstrate decreased interferon-γ (IFNγ) production in stimulated natural killer cells, and decreased circulating IFNγ concentrations during acute NTS bacteraemia. 29523850 2018
dbSNP: rs13390936
rs13390936
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004364
Disease:
Autoimmune Diseases
0.010 GeneticVariation BEFREE The NTS-risk allele at rs13390936 is associated with protection against a range of autoimmune diseases. 29523850 2018
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0017661
Disease:
IGA Glomerulonephritis
0.010 GeneticVariation BEFREE This is the first study demonstrating the significant associations of SNP rs3077, rs9277535 and rs7574865 and the haplotypes in the HLA gene with the risk of IgAN in a Southwest Chinese population. 29467950 2018
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0026896
Disease:
Myasthenia Gravis
0.010 GeneticVariation BEFREE The strongest signals of association were observed in the cases of rs6679356 between the late-onset MG patients and controls and rs7574865 between early-onset MG and controls. 29576322 2018
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3840565
Disease:
Autoimmune thyroid disease (AITD)
0.010 GeneticVariation BEFREE <b>Conclusion:</b> This meta-analysis showed a significant association between <i>STAT4</i> rs7574865 polymorphism and AITD susceptibility. 30666271 2018
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0677607
Disease:
Hashimoto Disease
0.010 GeneticVariation BEFREE <i>STAT4</i> rs7574865 polymorphism was significantly associated both with Graves' disease (GD) and Hashimoto's thyroiditis (HT) susceptibility. 30666271 2018
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0178468
Disease:
Autoimmune thyroid disease
0.010 GeneticVariation BEFREE The Association Between <i>STAT4</i> rs7574865 Polymorphism and the Susceptibility of Autoimmune Thyroid Disease: A Meta-Analysis. 30666271 2018
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0027873
Disease:
Neuromyelitis Optica
0.010 GeneticVariation BEFREE After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004). 28852993 2017
dbSNP: rs10181656
rs10181656
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0027873
Disease:
Neuromyelitis Optica
0.010 GeneticVariation BEFREE After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004). 28852993 2017
dbSNP: rs1031509
rs1031509
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE Furthermore, having TG + GG genotypes on rs1031509 near STAT4 was associated with 5-times (95% CI, 3.03-8.55) greater odds of asthma diagnosis at the highest B[a]P range, compared to the odds at the reference range. 28807506 2017
dbSNP: rs13426947
rs13426947
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0027873
Disease:
Neuromyelitis Optica
0.010 GeneticVariation BEFREE After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004). 28852993 2017
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0241910
Disease:
Autoimmune Chronic Hepatitis
0.010 GeneticVariation BEFREE We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk. 28977835 2017
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C4721555
Disease:
Autoimmune hepatitis
0.010 GeneticVariation BEFREE We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk. 28977835 2017
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0027873
Disease:
Neuromyelitis Optica
0.010 GeneticVariation BEFREE After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004). 28852993 2017
dbSNP: rs7582694
rs7582694
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0241910
Disease:
Autoimmune Chronic Hepatitis
0.010 GeneticVariation BEFREE We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk. 28977835 2017
dbSNP: rs7582694
rs7582694
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C4721555
Disease:
Autoimmune hepatitis
0.010 GeneticVariation BEFREE We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk. 28977835 2017