Disease: Juvenile rheumatoid arthritis ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3714757
Disease:
Juvenile rheumatoid arthritis 		0.020 GeneticVariation BEFREE STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients. 25781893 2015
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3714757
Disease:
Juvenile rheumatoid arthritis 		0.020 GeneticVariation BEFREE Our meta-analysis revealed that the STAT4 rs7574865 polymorphism is associated with four autoimmune diseases with systemic pathology, including systemic lupus erythematosus (OR = 1.52; 95% CI = 1.48 - 1.56, P<1.0 × 10(-16)), rheumatoid arthritis (OR = 1.27; 95% CI = 1.21 - 1.33, P < 1.00 × 10(-16)), systemic sclerosis (OR = 1.38; 95% CI = 1.27 - 1.50, P < 1.44 × 10(-14)), and primary Sjogren's syndrome (OR = 1.32; 95% CI = 1.01 - 1.73, P = 4.40 × 10(-2)), while no association was found with type I diabetes, juvenile idiopathic arthritis, ulcerative colitis and Crohn's disease. 23628400 2013