Variant Gene Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE Association of PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms with rheumatoid arthritis: A meta-analysis update. 25963842 2016
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE MDR analysis revealed significant gene-gene interactions among glutathione-S-transferase (GST)T1 and STAT4 (rs3821236 and rs7574865) polymorphisms, which account for moderate predictability of SLE. 26689915 2016
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE An updated meta-analysis of the signal transducer and activator of transcription 4 (STAT4) rs7574865 G/T polymorphism and rheumatoid arthritis risk in an Asian population. 25179669 2015
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASCAT GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. 24871463 2015
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASDB GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. 24871463 2015
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE Furthermore, the stratified meta-analysis also demonstrate that the STAT4 rs7574865 polymorphism is associated with the presence of autoantibodies with systemic reactivity (anti-ds-DNA antibodies) in SLE patients (OR = 1.37; 95% CI = 1.21 - 1.56, P = 1.12 × 10(-6)). 23628400 2014
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE Our meta-analysis revealed that the STAT4 rs7574865 polymorphism is associated with four autoimmune diseases with systemic pathology, including systemic lupus erythematosus (OR = 1.52; 95% CI = 1.48 - 1.56, P<1.0 × 10(-16)), rheumatoid arthritis (OR = 1.27; 95% CI = 1.21 - 1.33, P < 1.00 × 10(-16)), systemic sclerosis (OR = 1.38; 95% CI = 1.27 - 1.50, P < 1.44 × 10(-14)), and primary Sjogren's syndrome (OR = 1.32; 95% CI = 1.01 - 1.73, P = 4.40 × 10(-2)), while no association was found with type I diabetes, juvenile idiopathic arthritis, ulcerative colitis and Crohn's disease. 23628400 2014
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE Association of STAT4 rs7574865 with susceptibility to systemic lupus erythematosus in Iranian population. 23912645 2014
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE Data on rs7574865 in the STAT4 gene and rs9138 in SPP1 were replicated for associations with SLE when comparing cases and controls (corrected P values ranging from 0.0043 to 0.027). 24023622 2014
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE STAT4 rs7574865 is significantly associated with RA susceptibility in northern Chinese Han subpopulations. 23773642 2014
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE One of these SNP, rs7574865, showed a similar pattern of the association in serologically distinct subgroups of RA in a metaanalysis of all 7 published studies. 22753649 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASCAT Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASDB Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASDB Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis. 23053960 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. 22937072 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASCAT Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis. 23053960 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE Replication study of STAT4 rs7574865 G/T polymorphism and risk of rheumatoid arthritis in a Chinese population. 23727609 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE Genetic polymorphism rs7574865 in STAT4 gene might be associated with RA susceptibility in total subjects, major ethnic groups and different status of anti-CCP or RF. 23295549 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE Childhood-onset RA was associated with TNFAIP3 rs10499194 (OR 0.60 [95% confidence interval 0.44-0.83]), PTPN22 rs2476601 (OR 1.61 [95% confidence interval 1.11-2.31]), and STAT4 rs7574865 (OR 1.41 [95% confidence interval 1.06-1.87]) variants. 23450725 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE This meta-analysis demonstrates that the STAT4 rs7574865 T allele confers susceptibility to SLE, RA, T1D, SSc, JIA, APS, IBD-UC, and pSS patients, supporting the hypothesis of association between STAT4 gene polymorphism and subgroup of autoimmune diseases. 22714917 2012
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE We investigated whether a single nucleotide polymorphism (SNP) of the STAT4 (rs7574865), PTPN22 (rs2476601), TRAF1/C5 (rs10818488), and C1q (rs292001) genes as well as the 27-bp VNTR polymorphism on intron 4 of eNOS, previously associated with SLE in other populations, are also associated with SLE risk in Turkey. 21968398 2012
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation GWASDB Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. 22446963 2012
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASCAT Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. 21408207 2011
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.900 GeneticVariation BEFREE The genotype and allele distributions of four polymorphisms were significantly different in individuals with RA compared to controls, with SNP rs7574865 T allele and T/T genotype showing the most significant association with susceptibility to RA (uncorrected P=1×10(-4), OR=1.645, 95% CI=1.272-2.129; uncorrected P=4.8×10(-5), OR=3.111, 95% CI=1.777-5.447, respectively). 21683716 2011