AURKA, aurora kinase A, 6790

N. diseases: 245; N. variants: 15
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2180691
rs2180691
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C1261502
Disease:
Finding of Mean Corpuscular Hemoglobin
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs6024836
rs6024836
Entrez Id: 6790;116151
Gene Symbol: AURKA;FAM210B
AURKA;FAM210B
CUI: C0005890
Disease:
Body Height
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C4016820
Disease:
COLON CANCER, SUSCEPTIBILITY TO
T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE We found significant association between the AURKA T91A (rs2273535) (Phe21Ile) genotype and an increased risk of BC development: Phe/Ile (odds ratio [OR] = 2.6; 95% confidence interval [CI] = 1.4-4.9; P = 0.004), Ile/Ile (OR = 3.8; 95% CI = 1.6-9.0; P = 0.002), and Phe/Ile + Ile/Ile (OR = 2.9; 95% CI = 1.6-5.2; P = 0.001). 28647900 2018
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE We found significant association between the AURKA T91A (rs2273535) (Phe21Ile) genotype and an increased risk of BC development: Phe/Ile (odds ratio [OR] = 2.6; 95% confidence interval [CI] = 1.4-4.9; P = 0.004), Ile/Ile (OR = 3.8; 95% CI = 1.6-9.0; P = 0.002), and Phe/Ile + Ile/Ile (OR = 2.9; 95% CI = 1.6-5.2; P = 0.001). 28647900 2018
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE However, there was a significant association between tumor stages and F31I genotype (P for trend = .003).This is the first report of F31I and V57I polymorphisms in AURKA gene in breast cancer in Iran. 28906374 2017
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE However, there was a significant association between tumor stages and F31I genotype (P for trend = .003).This is the first report of F31I and V57I polymorphisms in AURKA gene in breast cancer in Iran. 28906374 2017
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE In addition, the variant Phe allele in STK15 rs2273535 SNP appeared to protect against breast cancer in Malaysian Chinese. 26925658 2016
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE In addition, the variant Phe allele in STK15 rs2273535 SNP appeared to protect against breast cancer in Malaysian Chinese. 26925658 2016
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that STK15 F31I polymorphism is associated with increased breast cancer and ovarian cancer risk among Caucasians, F31I polymorphism is associated with decreased lung cancer risk among Caucasians, and V57I polymorphism is associated with decreased breast cancer risk among Caucasians. 25154511 2015
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that STK15 F31I polymorphism is associated with increased breast cancer and ovarian cancer risk among Caucasians, F31I polymorphism is associated with decreased lung cancer risk among Caucasians, and V57I polymorphism is associated with decreased breast cancer risk among Caucasians. 25154511 2015
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Stratified analysis by cancer type revealed that the STK rs2273535 polymorphism may contribute to the risk of breast cancer (AA vs. TT: OR=1.21, 95%CI=1.01-1.44, Pheterogeneity=0.002), colorectal cancer (AA vs. 24252226 2014
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE A significant association was thus observed between the rs2273535 polymorphism in the AURKA gene and breast cancer risk. 25169513 2014
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE Stratified analysis by cancer type revealed that the STK rs2273535 polymorphism may contribute to the risk of breast cancer (AA vs. TT: OR=1.21, 95%CI=1.01-1.44, Pheterogeneity=0.002), colorectal cancer (AA vs. 24252226 2014
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE A significant association was thus observed between the rs2273535 polymorphism in the AURKA gene and breast cancer risk. 25169513 2014
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE The present meta-analysis suggests that the STK15 F31I polymorphism is a strong predisposing risk factor for breast cancer, but no significant association existed between the STK15 V57I polymorphism and the risk of breast cancer. 23803310 2013
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE The present meta-analysis suggests that the STK15 F31I polymorphism is a strong predisposing risk factor for breast cancer, but no significant association existed between the STK15 V57I polymorphism and the risk of breast cancer. 23803310 2013
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE Our results indicate statistical evidence of an association between the STK15 F31I polymorphism and the increased risk of overall cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T. In a stratified analysis by cancer type, there was an increased risk of breast cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T, as well as esophageal cancer in two genetic models: AA vs. TA+TT and AA vs. TA. 24349361 2013
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Our results indicate statistical evidence of an association between the STK15 F31I polymorphism and the increased risk of overall cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T. In a stratified analysis by cancer type, there was an increased risk of breast cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T, as well as esophageal cancer in two genetic models: AA vs. TA+TT and AA vs. TA. 24349361 2013
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE The results showed that four SNPs in AURKA (data in recessive model, rs2273535: OR = 2.19, 95% CI = 1.03-4.66, p = 0.0422; rs2298016: OR = 0.38, 95% CI = 0.18-0.82, p = 0.0141; rs6024836: OR = 1.54, 95% CI = 1.18-2.00, p = 0.0014; rs10485805: OR = 0.68, 95% CI = 0.47-0.98, p = 0.0380) and one SNP in BRCA1 (rs3737559, dominant model OR = 1.35, 95% CI = 1.11-1.64, p = 0.0030) were associated with breast cancer susceptibility. 21598251 2011
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE The results showed that four SNPs in AURKA (data in recessive model, rs2273535: OR = 2.19, 95% CI = 1.03-4.66, p = 0.0422; rs2298016: OR = 0.38, 95% CI = 0.18-0.82, p = 0.0141; rs6024836: OR = 1.54, 95% CI = 1.18-2.00, p = 0.0014; rs10485805: OR = 0.68, 95% CI = 0.47-0.98, p = 0.0380) and one SNP in BRCA1 (rs3737559, dominant model OR = 1.35, 95% CI = 1.11-1.64, p = 0.0030) were associated with breast cancer susceptibility. 21598251 2011
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE High mammographic density, associated with increased breast cancer risk, was encountered more frequently in premenopausal women with the risk genotypes STK15 F31I AA and AT. 21412660 2011
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis indicates that the AURKA T91A polymorphism is not a risk factor for developing breast cancer. 20464476 2011
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis indicates that the AURKA T91A polymorphism is not a risk factor for developing breast cancer. 20464476 2011
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C0678222
Disease:
Breast Carcinoma
0.100 GeneticVariation BEFREE High mammographic density, associated with increased breast cancer risk, was encountered more frequently in premenopausal women with the risk genotypes STK15 F31I AA and AT. 21412660 2011