rs1800574
HNF1A;HNF1A-AS1
Diabetes Mellitus, Non-Insulin-Dependent
0.850
GeneticVariation
BEFREE
We hypothesized that common variants at the <i>HNF1A</i> locus (rs1169288 [I27L], rs1800574 [A98V ]), which are associated with type 2 diabetes susceptibility, may modify age at diabetes diagnosis in individuals with HNF1A-MODY.
29895593
2018
rs1800574
HNF1A;HNF1A-AS1
Diabetes Mellitus, Non-Insulin-Dependent
T
0.850
GeneticVariation
GWASCAT
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
29632382
2018
rs1800574
HNF1A;HNF1A-AS1
Diabetes Mellitus, Non-Insulin-Dependent
0.850
GeneticVariation
BEFREE
The common variants p.I27L (rs1169288), p.A98V (rs1800574 ) and p.S487N (rs2464196) of the hepatocyte nuclear factor 1-α (HNF1A) gene have been inconsistently associated with impaired glucose tolerance and/or an increased risk of type 2 diabetes mellitus (T2DM ).
24933231
2015
rs1800574
HNF1A;HNF1A-AS1
Diabetes Mellitus, Non-Insulin-Dependent
0.850
GeneticVariation
GWASDB
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
22325160
2012
rs1800574
HNF1A;HNF1A-AS1
Diabetes Mellitus, Non-Insulin-Dependent
0.850
GeneticVariation
BEFREE
Significant associations between the heterozygote A98V genotype and clinical parameters of insulin metabolism were reported but no relationship with type 2 diabetes was obtained.
18777455
2008
rs1800574
HNF1A;HNF1A-AS1
Diabetes Mellitus, Non-Insulin-Dependent
0.850
GeneticVariation
BEFREE
We studied the effect of four common polymorphisms (rs1920792, I27L, A98V and S487N) in and upstream of the HNF-1alpha gene on transcriptional activity in vitro, and their possible association with type 2 diabetes and insulin secretion in vivo.
17033837
2006
rs1800574
HNF1A;HNF1A-AS1
Diabetes Mellitus, Non-Insulin-Dependent
0.850
GeneticVariation
BEFREE
Polymorphisms of these genes (Ala45Thr [NEUROD1], Ser199Phe [NEUROG3], and Ala98Val [TCF1]) have been postulated to influence the development of type 2 diabetes .
15277395
2004
rs2259816
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
Coronary heart disease
0.820
GeneticVariation
GWASDB
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
21347282
2011
rs2259816
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
Coronary heart disease
0.820
GeneticVariation
BEFREE
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
22152955
2011
rs2259816
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
Coronary heart disease
0.820
GeneticVariation
BEFREE
In the LURIC Study cohort the A-allele of rs2259816 is associated with decreased CRP but not with coronary artery disease .
21062467
2010
rs2259816
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
Coronary heart disease
T
0.820
GeneticVariation
GWASCAT
New susceptibility locus for coronary artery disease on chromosome 3q22.3.
19198612
2009
rs2259816
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
Coronary heart disease
T
0.820
GeneticVariation
GWASDB
New susceptibility locus for coronary artery disease on chromosome 3q22.3.
19198612
2009
rs1169288
HNF1A;HNF1A-AS1
Low density lipoprotein cholesterol measurement
0.800
GeneticVariation
GWASCAT
Genetic analyses of diverse populations improves discovery for complex traits.
31217584
2019
rs1169288
HNF1A;HNF1A-AS1
Low density lipoprotein cholesterol measurement
A
0.800
GeneticVariation
GWASCAT
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
30926973
2019
rs1169310
HNF1A;C12orf43
C-reactive protein measurement
0.800
GeneticVariation
GWASCAT
Genetic analyses of diverse populations improves discovery for complex traits.
31217584
2019
rs1183910
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
C-reactive protein measurement
0.800
GeneticVariation
GWASCAT
Genetic analyses of diverse populations improves discovery for complex traits.
31217584
2019
rs2259816
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
C-reactive protein measurement
0.800
GeneticVariation
GWASCAT
Genetic analyses of diverse populations improves discovery for complex traits.
31217584
2019
rs2393791
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
C-reactive protein measurement
0.800
GeneticVariation
GWASCAT
Genetic analyses of diverse populations improves discovery for complex traits.
31217584
2019
rs7310409
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
C-reactive protein measurement
0.800
GeneticVariation
GWASCAT
Genetic analyses of diverse populations improves discovery for complex traits.
31217584
2019
rs7979473
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
C-reactive protein measurement
0.800
GeneticVariation
GWASCAT
Genetic analyses of diverse populations improves discovery for complex traits.
31217584
2019
rs1169288
HNF1A;HNF1A-AS1
Low density lipoprotein cholesterol measurement
A
0.800
GeneticVariation
GWASCAT
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
30275531
2018
rs1169288
HNF1A;HNF1A-AS1
Serum total cholesterol measurement
A
0.800
GeneticVariation
GWASCAT
A large electronic-health-record-based genome-wide study of serum lipids.
29507422
2018
rs1169288
HNF1A;HNF1A-AS1
Low density lipoprotein cholesterol measurement
A
0.800
GeneticVariation
GWASCAT
A large electronic-health-record-based genome-wide study of serum lipids.
29507422
2018
rs1169288
HNF1A;HNF1A-AS1
Serum total cholesterol measurement
A
0.800
GeneticVariation
GWASCAT
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
30275531
2018
rs7310409
×
Entrez Id:
6927
Gene Symbol:
HNF1A
HNF1A
C-reactive protein measurement
G
0.800
GeneticVariation
GWASCAT
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
30388399
2018